ES8205198A1 - Mejoras en un procedimiento mejorado para preparar 2-cloro- sulfinilazetidin-4-ona. - Google Patents

Mejoras en un procedimiento mejorado para preparar 2-cloro- sulfinilazetidin-4-ona.

Info

Publication number
ES8205198A1
ES8205198A1 ES484918A ES484918A ES8205198A1 ES 8205198 A1 ES8205198 A1 ES 8205198A1 ES 484918 A ES484918 A ES 484918A ES 484918 A ES484918 A ES 484918A ES 8205198 A1 ES8205198 A1 ES 8205198A1
Authority
ES
Spain
Prior art keywords
chlorine
weight
penicillin sulfoxide
chlorosulfinyl
azetidinones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES484918A
Other languages
English (en)
Other versions
ES484918A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES484918A0 publication Critical patent/ES484918A0/es
Publication of ES8205198A1 publication Critical patent/ES8205198A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE 2-CLORO-SULFINILAZETIDIN-4-ONA. CONSISTE EN HACER REACCIONAR EN UN DISOLVENTE ORGANICO INERTE Y EN CONDICIONES ANHIDRAS UN ESTER DE SULFOXIDO DE PENICILINA CON UN AGENTE HALOGENANTE N-CLORO, EN PRESENCIA DE UNPOLIMERO DE POLIVINILPIRIDINA RETICULADO QUE CONTIENE DE UN 1 A UN 100 DE RETICULACION. LA EMPERATURA OSCILA ENTRE 75 Y 175 GRADOS CENTIGRADOS. LA RELACION EN PESO DEL POLIMERO AL SULFOXIDO DE PENICILINA ES DE 1:1 A 1:5 EN PESO. EN AGENTE DE RETICULACION ES DIVINILBENCENO, METILENBISACRILAMIDO O METILENBISMETACRILAMIDA. EL COMPUESTO OBTENIDO TIENE DE FORMULA GENERAL (I).
ES484918A 1978-11-13 1979-10-10 Mejoras en un procedimiento mejorado para preparar 2-cloro- sulfinilazetidin-4-ona. Expired ES8205198A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96034778A 1978-11-13 1978-11-13
US06/049,266 US4289695A (en) 1978-11-13 1979-06-18 Process for preparing 2-chlorosulfinylazetidinones

Publications (2)

Publication Number Publication Date
ES484918A0 ES484918A0 (es) 1981-11-01
ES8205198A1 true ES8205198A1 (es) 1981-11-01

Family

ID=26727009

Family Applications (1)

Application Number Title Priority Date Filing Date
ES484918A Expired ES8205198A1 (es) 1978-11-13 1979-10-10 Mejoras en un procedimiento mejorado para preparar 2-cloro- sulfinilazetidin-4-ona.

Country Status (22)

Country Link
US (1) US4289695A (es)
EP (1) EP0011370B1 (es)
AU (1) AU5147679A (es)
CA (1) CA1131646A (es)
CH (1) CH642624A5 (es)
DD (1) DD146458A5 (es)
DE (1) DE2962639D1 (es)
DK (1) DK165687C (es)
ES (1) ES8205198A1 (es)
FI (1) FI793095A (es)
FR (1) FR2440945A1 (es)
GB (1) GB2034701B (es)
GR (1) GR73093B (es)
HU (1) HU180232B (es)
IE (1) IE48963B1 (es)
IL (1) IL58405A (es)
LU (1) LU81768A1 (es)
NO (1) NO793272L (es)
OA (1) OA06356A (es)
PL (1) PL218929A1 (es)
PT (1) PT70264A (es)
YU (1) YU241279A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE138664T1 (de) * 1985-08-12 1996-06-15 Upjohn Co Umwandlung des cephalosporin-hydrohalid-salzes zu einem alkalimetallsalz
FI103048B1 (fi) * 1989-03-22 1999-04-15 Dsm Nv Menetelmä 3-eksometyleenikefaamisulfoksidijohdannaisten valmistamiseksi
US4950753A (en) 1989-05-17 1990-08-21 Eli Lilly And Company Process for 3-exomethylenecepham sulfoxide esters
IN173329B (es) * 1989-11-06 1994-04-02 Ranbaxy Lab Ltd
US5126446A (en) * 1991-01-04 1992-06-30 Eli Lilly And Company Process for 3-exomethylenecepham sulfoxide esters
US5350845A (en) * 1992-04-08 1994-09-27 Eli Lilly And Company Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters
US5347000A (en) * 1992-11-05 1994-09-13 Ranbaxy Laboratories Ltd. Process for the preparation of 2-chlorosulfinylazetidinone
US5604222A (en) * 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en) * 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
AUPP939299A0 (en) * 1999-03-23 1999-04-15 University Of Melbourne, The Polymer gels and methods for their preparation
CN1281711C (zh) * 2002-04-16 2006-10-25 Sasol技术股份有限公司 采用烃合成催化剂和酸性催化剂的烃合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1056372A (en) * 1974-12-24 1979-06-12 Eli Lilly And Company Method of preparation of 3-methylenecephams
CA1069126A (en) * 1974-12-24 1980-01-01 Eli Lilly And Company Sulfinyl halides and their preparation from penicillin sulfoxides
US4075203A (en) * 1976-06-16 1978-02-21 Eli Lilly And Company Process for preparing a 3-exomethylenecepham sulfoxide from penicillin sulfoxides
US4159272A (en) * 1977-09-01 1979-06-26 Eli Lilly And Company Process for 2-chlorosulfinylazetidin-4-ones

Also Published As

Publication number Publication date
FR2440945B1 (es) 1982-12-31
YU241279A (en) 1983-10-31
FR2440945A1 (fr) 1980-06-06
DK431379A (da) 1980-05-14
ES484918A0 (es) 1981-11-01
CH642624A5 (fr) 1984-04-30
DD146458A5 (de) 1981-02-11
IL58405A0 (en) 1980-01-31
IL58405A (en) 1982-08-31
GR73093B (es) 1984-02-01
NO793272L (no) 1980-05-14
EP0011370A1 (en) 1980-05-28
DK165687C (da) 1993-06-07
IE791940L (en) 1980-05-13
US4289695A (en) 1981-09-15
AU5147679A (en) 1980-05-22
LU81768A1 (fr) 1980-01-24
OA06356A (fr) 1981-06-30
PT70264A (en) 1979-11-01
GB2034701B (en) 1983-06-15
HU180232B (en) 1983-02-28
EP0011370B1 (en) 1982-04-28
DE2962639D1 (en) 1982-06-09
FI793095A (fi) 1980-05-14
GB2034701A (en) 1980-06-11
DK165687B (da) 1993-01-04
CA1131646A (en) 1982-09-14
PL218929A1 (es) 1980-06-16
IE48963B1 (en) 1985-06-26

Similar Documents

Publication Publication Date Title
ES8205198A1 (es) Mejoras en un procedimiento mejorado para preparar 2-cloro- sulfinilazetidin-4-ona.
JPS55160786A (en) Hydroalkenyloxysilane
ES419016A1 (es) Procedimiento para la produccion de compuesto del acido 13-bromo - lisergico.
ES328674A1 (es) Procedimiento para la produccion de alcaloides.
ES8506671A1 (es) Un procedimiento para la preparacion de 3-formil-2-nitrometilen-tetrahidro-2h-1, 3-tiazina
ES381199A1 (es) Un procedimiento para preparar compuestos absorbentes de laluz ultravioleta.
ES444439A1 (es) Procedimiento para la obtencion de carbonatos de cetooxima.
JPS5473775A (en) Isoxazoline-3-one derivative
ES377089A1 (es) Procedimiento para la obtencion de derivados de imidazo (2,1-a) isoindol.
ES281171A1 (es) Un método para la preparación de compuestos de la fórmula: z-a-nr-ch2-c=c-h
ES324287A1 (es) Procedimiento para la obtencion de esteres del acido 8-quinolil-carbaminico de efecto fungicida.
ES474039A1 (es) Procedimiento para la obtencion de 4-(p-clorobenzoil)-feno- xiiobutirato de n-bencidril-n'-trans-cinnamilpiperacina.
FR2313339A1 (fr) Procede de preparation de 3-bromobenzaldehyde
ES482576A3 (es) Procedimiento para la fabricacion de 1,4-dioxido de 3-(2- quinoxalinilmetilen) carbazato de metilo.
ES467999A1 (es) Un procedimiento para la preparacion de derivados de 5,8-di-hidro-6,6,8-trimetil-5,8-etano-6h-pirano(4,3-e)-as-triazinasy sus 4-oxidos
ES453269A1 (es) Procedimiento para la obtencion de n-3, 4 metilendioxibencil-n' 3, 7, 11-trimetil 2, 6, 10 dodecatrienilpiperazina.
JPS53111081A (en) Preparation of bromophenothiazine
ES475279A1 (es) Procedimiento de obtencion de n1-(2'-furanidil)-5-uracilos sustituidos por halogeno.
ES471436A1 (es) Procedimiento de obtencion del acido 1-benzoil-2-metilindol-3-acetico
ES8206439A1 (es) Procedimiento para la obtencion de 1-(2-aliloxifenoxi)-3- isopropilamino-2-propanol
ES462728A1 (es) Procedimiento para la obtencion de p-clorofenoxiisobutirato de p-clorofenoxiisobutilo.
ES8106503A1 (es) Procedimiento para la obtencion de compuestos heterociclicosnitrogenados
ES438241A1 (es) Un proceso para preparar un 2-(6-metoxi-2-naftil) propionatode alquilo.
GB1274595A (en) Esters of chrysanthemic acid
ES453718A1 (es) Un procedimiento analogico de preparacion de una sal de adi-cion de acido.