ES8204995A1 - Procedimiento para la obtencion de espiro-1,4-dihidropiridi-nas 4,4-disustituidas - Google Patents

Procedimiento para la obtencion de espiro-1,4-dihidropiridi-nas 4,4-disustituidas

Info

Publication number
ES8204995A1
ES8204995A1 ES503371A ES503371A ES8204995A1 ES 8204995 A1 ES8204995 A1 ES 8204995A1 ES 503371 A ES503371 A ES 503371A ES 503371 A ES503371 A ES 503371A ES 8204995 A1 ES8204995 A1 ES 8204995A1
Authority
ES
Spain
Prior art keywords
formula
intermediates
producing
compounds
dihydropyridines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503371A
Other languages
English (en)
Other versions
ES503371A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8204995A1 publication Critical patent/ES8204995A1/es
Publication of ES503371A0 publication Critical patent/ES503371A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ESPRIO-1,4-DIHIDROPIRIDINAS 4,4-DISUSTIUIDAS, DE FORMULA (I), EN LA QUE A ES UN DERIVADO DE ARILO O DE UNO DE VARIOS HETEROCICLOS; R1-R5 PUEDEN SER VARIOS TIPOS DE RADICALES Y "N" VALE DE 0 A 2. CONSISTE EN LA REACCION DE CICLISACION DE PIRIDINAS DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA DISOLUCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE BASES ORGANICAS O INORGANICAS, A TEMPERATURAS ENTRE -120 Y 30 C. ESTOS COMPUESTOS TIENEN APLICACIONES COMO INTERMEDIOS PARA LA SINTESIS DE 1,4-DIHIDROPIRIDINAS 4,4-DISUSTITUIDAS, QUE SE EMPLEAN PARA EL TRATAMIENTO DE ENFERMEDADES CIRUCULATORIAS.
ES503371A 1980-06-25 1981-06-25 Procedimiento para la obtencion de espiro-1,4-dihidropiridi-nas 4,4-disustituidas Granted ES503371A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803023820 DE3023820A1 (de) 1980-06-25 1980-06-25 4,4-disubstituierte spiro-1,4-dihydropyridine, ein verfahren zu ihrer herstellung, sowie ihre verwendung als zwischenprodukt

Publications (2)

Publication Number Publication Date
ES8204995A1 true ES8204995A1 (es) 1982-05-16
ES503371A0 ES503371A0 (es) 1982-05-16

Family

ID=6105449

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503371A Granted ES503371A0 (es) 1980-06-25 1981-06-25 Procedimiento para la obtencion de espiro-1,4-dihidropiridi-nas 4,4-disustituidas

Country Status (6)

Country Link
US (1) US4349675A (es)
EP (1) EP0042569B1 (es)
JP (1) JPS5732287A (es)
AT (1) ATE4985T1 (es)
DE (2) DE3023820A1 (es)
ES (1) ES503371A0 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3209276A1 (de) * 1982-03-13 1983-09-15 Bayer Ag, 5090 Leverkusen Arzneimittel mit antihypoxischer und ischaemie-protektiver wirkung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
JPS5732287A (en) 1982-02-20
EP0042569B1 (de) 1983-10-12
DE3023820A1 (de) 1982-01-14
US4349675A (en) 1982-09-14
ATE4985T1 (de) 1983-10-15
EP0042569A1 (de) 1981-12-30
DE3161175D1 (en) 1983-11-17
ES503371A0 (es) 1982-05-16

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