ES8203384A1 - Procedimiento de preparacion de cefalosporinas oxidas - Google Patents

Procedimiento de preparacion de cefalosporinas oxidas

Info

Publication number
ES8203384A1
ES8203384A1 ES81503563A ES503563A ES8203384A1 ES 8203384 A1 ES8203384 A1 ES 8203384A1 ES 81503563 A ES81503563 A ES 81503563A ES 503563 A ES503563 A ES 503563A ES 8203384 A1 ES8203384 A1 ES 8203384A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
hydrogen
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES81503563A
Other languages
English (en)
Other versions
ES503563A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8014512A external-priority patent/FR2485540A1/fr
Priority claimed from FR8104243A external-priority patent/FR2501209B1/fr
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8203384A1 publication Critical patent/ES8203384A1/es
Publication of ES503563A0 publication Critical patent/ES503563A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A61K47/552—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being an antibiotic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE CEFALOSPORINAS OXIDAS. CONSTA DE LAS SIGUIENTES ETAPAS: 1) REACCION DE UN SOLFOXIDO CON EL PRODUCTO HB, EN DIMETILFORMAMIDA, EN PRESENCIA DE UNA BASE TAL COMO LA TRIETILFORMAMIDA O LA TRIETILAMINA. 2) SE LIBERA EL GRUPO AMINO POR ACCION DEL CLORURO DE TIONILO. 3) EL PRODUCTO OBTENIDO SE ACILA CON AYUDA DEL COMPUESTO (I) EN EL TR ES UN GRUPO PROTECTOR DEL RADICAL AMINO (TAL COMO EL GRUPO TRTILO); EL RADICAL ACIDO SE ACTIVA MEDIANTE LA TRANSFORMACION EN ANHIDRIDO. 4) SE ELIMINA EL RADICAL PROTECTOR DE LA AMINA (TR) Y EL ESTER TERTIOBUTILO DEL NUCLEO CEFEMA POR HIDROLISIS EN MEDIO ACIDO. SE OBTIENE EL COMPUESTO (III).
ES503563A 1980-06-30 1981-06-30 Procedimiento de preparacion de cefalosporinas oxidas Granted ES503563A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8014512A FR2485540A1 (fr) 1980-06-30 1980-06-30 Nouveaux derives antibiotiques des cephalosporines, leur procede de preparation et les medicaments en contenant
FR8104242 1981-03-03
FR8104243A FR2501209B1 (fr) 1981-03-03 1981-03-03 Nouveaux derives des cephalosporines et medicaments antibiotiques contenant lesdits derives

Publications (2)

Publication Number Publication Date
ES8203384A1 true ES8203384A1 (es) 1982-04-01
ES503563A0 ES503563A0 (es) 1982-04-01

Family

ID=27251008

Family Applications (2)

Application Number Title Priority Date Filing Date
ES503563A Granted ES503563A0 (es) 1980-06-30 1981-06-30 Procedimiento de preparacion de cefalosporinas oxidas
ES503562A Granted ES503562A0 (es) 1980-06-30 1981-06-30 Procedimiento de preparacion de 3-(1,2,4-hidroxitriazinil) tiometil cefalosporinas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES503562A Granted ES503562A0 (es) 1980-06-30 1981-06-30 Procedimiento de preparacion de 3-(1,2,4-hidroxitriazinil) tiometil cefalosporinas

Country Status (12)

Country Link
US (1) US4604387A (es)
EP (2) EP0043756B1 (es)
AU (1) AU543165B2 (es)
CA (2) CA1175806A (es)
DE (2) DE3162109D1 (es)
DK (2) DK283381A (es)
ES (2) ES503563A0 (es)
GR (2) GR75706B (es)
IE (2) IE51359B1 (es)
NO (2) NO812214L (es)
NZ (2) NZ197564A (es)
PT (2) PT73284A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2570702B1 (fr) * 1984-09-27 1987-01-09 Sanofi Sa Derives des cephalosporines, procedes d'obtention et leur application a titre d'antibiotiques
US5147871A (en) * 1986-07-03 1992-09-15 Hoffmann La-Roche, Inc. Anti-bacterial cephalosporin compounds
US5336768A (en) * 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
CS273349B2 (en) * 1988-03-31 1991-03-12 Hoffmann La Roche Method of cephalosporin's new derivatives production
US5159077A (en) * 1989-07-21 1992-10-27 Hoffmann-La Roche Inc. Penam antibacterial compounds
US5162523A (en) * 1989-07-21 1992-11-10 Hoffmann-La Roche Inc. Cephalosporin antibacterial compounds
US5318781A (en) * 1993-04-06 1994-06-07 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides
US4349672A (en) * 1979-11-29 1982-09-14 Hoffmann-La Roche Inc. Cephalosporin derivatives

Also Published As

Publication number Publication date
NZ197564A (en) 1983-12-16
PT73283B (fr) 1984-11-19
AU7241181A (en) 1982-01-07
AU543165B2 (en) 1985-04-04
NO159798B (no) 1988-10-31
IE51358B1 (en) 1986-12-10
EP0043756A1 (fr) 1982-01-13
DK283381A (da) 1981-12-31
US4604387A (en) 1986-08-05
ES8204996A1 (es) 1982-05-16
EP0044238A1 (fr) 1982-01-20
IE811453L (en) 1981-12-30
GR75711B (es) 1984-08-02
NO812214L (no) 1982-01-04
ES503563A0 (es) 1982-04-01
DE3162109D1 (en) 1984-03-08
CA1173434A (en) 1984-08-28
EP0043756B1 (fr) 1984-05-09
ES503562A0 (es) 1982-05-16
CA1175806A (en) 1984-10-09
EP0044238B1 (fr) 1984-02-01
NO812215L (no) 1982-01-04
GR75706B (es) 1984-08-02
DE3163490D1 (en) 1984-06-14
IE51359B1 (en) 1986-12-10
PT73284A (fr) 1981-07-01
DK283281A (da) 1981-12-31
IE811452L (en) 1981-12-30
PT73283A (fr) 1981-07-01
NO159798C (no) 1989-02-08
NZ197563A (en) 1983-11-30

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