ES8201126A1 - Prepn. of 2:amino 5:nitro benzophenone(s) - by reaction of 4:nitro benzanilide with benzoyl halide and hydrolysis - Google Patents
Prepn. of 2:amino 5:nitro benzophenone(s) - by reaction of 4:nitro benzanilide with benzoyl halide and hydrolysisInfo
- Publication number
- ES8201126A1 ES8201126A1 ES500078A ES500078A ES8201126A1 ES 8201126 A1 ES8201126 A1 ES 8201126A1 ES 500078 A ES500078 A ES 500078A ES 500078 A ES500078 A ES 500078A ES 8201126 A1 ES8201126 A1 ES 8201126A1
- Authority
- ES
- Spain
- Prior art keywords
- nitro
- hydrolysis
- benzanilide
- amino
- benzophenone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
2-amino-5-nitro benzophenone derivs. of formula (I) (where X= H or halogen), are prepd. by treatment of a 4-nitro benzanilide (II) with a benzoyl halide (II) in the presence of a Lewis acid catalyst, followed by acid hydrolysis. The pref. Lewis acid is zinc chloride and the preferred hydrolysis medium is a mixt. of acetic acid, sulphuric acid and water. (I) is an intermediate for medicaments such as nitrazepam, chlorazepam, flunitrazepam and 2-benzoyl-4-nitro glycylanilides. This process gives good yields of pure prod. and is simple to carry out.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8003266A FR2476070A1 (en) | 1980-02-14 | 1980-02-14 | Prepn. of 2:amino 5:nitro benzophenone(s) - by reaction of 4:nitro benzanilide with benzoyl halide and hydrolysis |
Publications (2)
Publication Number | Publication Date |
---|---|
ES500078A0 ES500078A0 (en) | 1981-12-16 |
ES8201126A1 true ES8201126A1 (en) | 1981-12-16 |
Family
ID=9238582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES500078A Expired ES8201126A1 (en) | 1980-02-14 | 1981-02-14 | Prepn. of 2:amino 5:nitro benzophenone(s) - by reaction of 4:nitro benzanilide with benzoyl halide and hydrolysis |
Country Status (3)
Country | Link |
---|---|
ES (1) | ES8201126A1 (en) |
FR (1) | FR2476070A1 (en) |
IT (1) | IT1170707B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103613548A (en) * | 2013-12-10 | 2014-03-05 | 沈阳药科大学 | Synthesis process of nizofenone fumarate |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD74798A (en) * | ||||
AT275502B (en) * | 1966-02-22 | 1969-10-27 | Richter Gedeon Vegyeszet | Process for the preparation of substituted 2-aminobenzophenones |
-
1980
- 1980-02-14 FR FR8003266A patent/FR2476070A1/en active Granted
-
1981
- 1981-02-12 IT IT47772/81A patent/IT1170707B/en active
- 1981-02-14 ES ES500078A patent/ES8201126A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES500078A0 (en) | 1981-12-16 |
IT8147772A0 (en) | 1981-02-12 |
IT8147772A1 (en) | 1982-08-12 |
FR2476070A1 (en) | 1981-08-21 |
IT1170707B (en) | 1987-06-03 |
FR2476070B1 (en) | 1983-12-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19960603 |