ES8200696A1 - Un procedimiento para la preparacion de nuevos compuestos amidicos de cefalosporina - Google Patents

Un procedimiento para la preparacion de nuevos compuestos amidicos de cefalosporina

Info

Publication number
ES8200696A1
ES8200696A1 ES497149A ES497149A ES8200696A1 ES 8200696 A1 ES8200696 A1 ES 8200696A1 ES 497149 A ES497149 A ES 497149A ES 497149 A ES497149 A ES 497149A ES 8200696 A1 ES8200696 A1 ES 8200696A1
Authority
ES
Spain
Prior art keywords
acylaminoacylamino
aminoacylamino
dihydro
phenyl
oxonicotinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497149A
Other languages
English (en)
Other versions
ES497149A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES497149A0 publication Critical patent/ES497149A0/es
Publication of ES8200696A1 publication Critical patent/ES8200696A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS AMIDICOS DE VEFALOSPORINA DE FORMULA (I) Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, EN LA QUE R1, R2, R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN AMINOACIDO DE FORMULA (II), O LA SAL ACIDA O EL DERIVADO SILILADO CORRESPONDIENTE, CON UN DERIVADO REACTIVO DE LA D-N-(6-(SUSTITUIDA)-1,2-DIHIDRO-2-OXONICOTINIL)-2-SUSTITUIDA-GLICINA DE FORMULA (III), O SUS SALES DE ADICION DE ACIDO, FORMULAS EN LAS QUE R1, R2, R3 Y R4 SON LOS MISMOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE A TEMPERATURAS COMPRENDIDAS ENTRE -30 Y 30 C Y LA SEPARACION Y PURIFICACION DEL PRODUCTO SE EFECTUA SIGUIENDO METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIBACTERIANOS.
ES497149A 1979-03-12 1980-11-26 Un procedimiento para la preparacion de nuevos compuestos amidicos de cefalosporina Expired ES8200696A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1998379A 1979-03-12 1979-03-12
US06/112,655 US4311698A (en) 1979-03-12 1980-01-31 Aminoacid derivatives of cephalosporin compounds

Publications (2)

Publication Number Publication Date
ES497149A0 ES497149A0 (es) 1981-11-01
ES8200696A1 true ES8200696A1 (es) 1981-11-01

Family

ID=26692834

Family Applications (2)

Application Number Title Priority Date Filing Date
ES489400A Expired ES8104306A1 (es) 1979-03-12 1980-03-11 Un procedimiento para la preparacion de nuevos compuestos amidicos de cefalosporina
ES497149A Expired ES8200696A1 (es) 1979-03-12 1980-11-26 Un procedimiento para la preparacion de nuevos compuestos amidicos de cefalosporina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES489400A Expired ES8104306A1 (es) 1979-03-12 1980-03-11 Un procedimiento para la preparacion de nuevos compuestos amidicos de cefalosporina

Country Status (8)

Country Link
US (1) US4311698A (es)
EP (1) EP0015771B1 (es)
AU (1) AU530301B2 (es)
CA (1) CA1147324A (es)
DE (1) DE3068089D1 (es)
DK (1) DK103780A (es)
ES (2) ES8104306A1 (es)
ZA (1) ZA801423B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404201A (en) * 1981-11-13 1983-09-13 Warner-Lambert Company Cephalosporins
JP4046708B2 (ja) * 2004-06-04 2008-02-13 明治製菓株式会社 ３−アルケニルセフェム化合物の製造方法
CN103145598B (zh) * 2011-12-07 2014-10-15 北京京卫顺康医药科技发展有限公司 一种奥沙西罗晶体及含有该晶体的组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954734A (en) * 1974-01-21 1976-05-04 Parke, Davis & Company Novel antibacterial amide compounds and process means for producing the same
ZA7546B (en) * 1974-01-21 1976-08-25 Parke Davis & Co New antibacterial amide compounds and methods for their production
US3946015A (en) * 1974-07-11 1976-03-23 Parke, Davis & Company Process for the preparation of acid chlorides
US3951982A (en) * 1974-11-21 1976-04-20 Parke, Davis & Company Trialkylsilyl esters of 6(substituted amino)phenyl-1,-dihydro-2-oxonicotinic acid, methods for their production and conversion to the corresponding acid chlorides
US4370326A (en) * 1977-09-13 1983-01-25 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and composition

Also Published As

Publication number Publication date
ZA801423B (en) 1981-03-25
ES497149A0 (es) 1981-11-01
AU5634180A (en) 1980-09-18
US4311698A (en) 1982-01-19
EP0015771A1 (en) 1980-09-17
ES489400A0 (es) 1981-04-16
EP0015771B1 (en) 1984-06-06
AU530301B2 (en) 1983-07-07
DE3068089D1 (en) 1984-07-12
DK103780A (da) 1980-09-13
CA1147324A (en) 1983-05-31
ES8104306A1 (es) 1981-04-16

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