ES8200372A1 - Procedimiento para la preparacion de compuestos lefemicos. - Google Patents

Procedimiento para la preparacion de compuestos lefemicos.

Info

Publication number
ES8200372A1
ES8200372A1 ES490163A ES490163A ES8200372A1 ES 8200372 A1 ES8200372 A1 ES 8200372A1 ES 490163 A ES490163 A ES 490163A ES 490163 A ES490163 A ES 490163A ES 8200372 A1 ES8200372 A1 ES 8200372A1
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl
optionally
membered heterocycle
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490163A
Other languages
English (en)
Other versions
ES490163A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8200372A1 publication Critical patent/ES8200372A1/es
Publication of ES490163A0 publication Critical patent/ES490163A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS CEFEMICOS DE FORMULA (I), DONDE N ES 0 O 1; R1 ES HIDROGENO O ALCOXI U R2 ES UN GRUPO AZIDO O UN RADICAL -SR3, DONDE R3 ES UN HETEROCICLO DE 5 O 6 MIEMBROS, CON EL QUE PUEDE ESTAR CONDENSADO UN NUCLEO BENCENICO O ALCOHILO. SE HACEN REACCIONAR COMPUESTOS CEFEMICOS DE FORMULA (II) CON AZIDAS, PREFERENTEMENTE AZIDAS DE METALES ALCALINOS. SE REALIZA EN SOLUCION OCUOSA O EN MEZCLAS CON AGUAS Y DISOLVENTES MISCIBLES TAL COMO ACETONA. LA TEMPERATURA DE REACCION DEBE ESTAR ENTRE 50 Y 80C. LOS COMPUESTOS PREPARADOS SE PUEDEN TRANSFORMAR EN UNA SAL OBTENIDA DEL ACIDO CARBOXILICO LIBRE, EN UNA SAL OBTENIDA DE ESTER O BIEN SAPONIFICANDO UN ESTER, EL ACIDO CARBOXILICO SE TRANSFORMA EN UNA SAL. EXISTE OTRO PROCEDIMIENTO PARTIENDO DE COMPUESTOS CEFEMICOS DE FORMULAS (III) EN FORMA DE SUS SALES O ESTERES. SE UTILIZAN PARA COMBATIR INFECCIOSOS GRAM-POSITIVOS Y SOBRE TODO GRAM-NEGATIVOS Y SON EFICACES FRENTE A ESTAFILOCOCOS FORMADORES DE PENICILINAS.
ES490163A 1979-04-09 1980-04-01 Procedimiento para la preparacion de compuestos lefemicos. Granted ES490163A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792914327 DE2914327A1 (de) 1979-04-09 1979-04-09 Cephemderivate und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8200372A1 true ES8200372A1 (es) 1981-10-16
ES490163A0 ES490163A0 (es) 1981-10-16

Family

ID=6067880

Family Applications (2)

Application Number Title Priority Date Filing Date
ES490163A Granted ES490163A0 (es) 1979-04-09 1980-04-01 Procedimiento para la preparacion de compuestos lefemicos.
ES497635A Expired ES8200693A1 (es) 1979-04-09 1980-12-11 Procedimiento para la preparacion de compuestos cefemicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES497635A Expired ES8200693A1 (es) 1979-04-09 1980-12-11 Procedimiento para la preparacion de compuestos cefemicos

Country Status (6)

Country Link
EP (1) EP0017238B1 (es)
JP (1) JPS55141490A (es)
AT (1) ATE2793T1 (es)
CA (1) CA1151151A (es)
DE (2) DE2914327A1 (es)
ES (2) ES490163A0 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE53429B1 (en) * 1981-08-03 1988-11-09 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
US4499088A (en) * 1983-01-04 1985-02-12 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS60190783A (ja) * 1983-12-21 1985-09-28 Sumitomo Seiyaku Kk セフエム系化合物
US4761409A (en) * 1984-08-16 1988-08-02 Sumitomo Pharmaceuticals Company, Limited Cephem derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
DE2822860A1 (de) * 1978-05-26 1979-11-29 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
ES497635A0 (es) 1981-11-01
EP0017238B1 (de) 1983-03-16
ES8200693A1 (es) 1981-11-01
EP0017238A1 (de) 1980-10-15
DE3062318D1 (en) 1983-04-21
CA1151151A (en) 1983-08-02
DE2914327A1 (de) 1980-10-30
ATE2793T1 (de) 1983-04-15
JPS55141490A (en) 1980-11-05
ES490163A0 (es) 1981-10-16

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