ES8200345A1 - Procedimiento para la preparacion de 2-halo piridinas - Google Patents

Procedimiento para la preparacion de 2-halo piridinas

Info

Publication number
ES8200345A1
ES8200345A1 ES498510A ES498510A ES8200345A1 ES 8200345 A1 ES8200345 A1 ES 8200345A1 ES 498510 A ES498510 A ES 498510A ES 498510 A ES498510 A ES 498510A ES 8200345 A1 ES8200345 A1 ES 8200345A1
Authority
ES
Spain
Prior art keywords
pyridines
halo
production
new
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498510A
Other languages
English (en)
Other versions
ES498510A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lacer SA
Original Assignee
Lacer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer SA filed Critical Lacer SA
Publication of ES498510A0 publication Critical patent/ES498510A0/es
Publication of ES8200345A1 publication Critical patent/ES8200345A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 2-HALOPIRIDINAS. RESPONDE A LA FORMULA GENERAL (I), DONDE X ES CL O BR; AR ES UN FENILO O UN FENILO SUSTITUIDO DE FORMULA (II), DONDE R ES UN ALQUILO, O UN ALCOXI, O UN FENOXI, O UN ALQUILTIO, O F, O CL, O BIEN -OH O -C6H5; Y A ES VO O -HOH DE FORMULAS RESPECTIVAS (IA, IB). PARA LA OBTENCION DEL COMPUESTO DE FORMULA (IB) SE HACE REACCIONAR UN HALOPIRIDIL-LITIO CON UN ALDEHIDO AROMATICO, PARA SEGUIDAMENTE HIDROLIZAR EL INTERMEDIO FORMADO; PARA LA OBTENCION DEL COMPUESTO DE FORMULA GENERAL (IA) SE HACE REACCIONAR UN COMPUESTO DE FORMULA (III) CON AGENTES HALOGENANTES COMO EL OXICLORURO DE FOSFORO, Y EL OXIBROMURO DE FOSFORO CON PENTACLORURO DE FOSFORO.
ES498510A 1980-01-16 1981-01-14 Procedimiento para la preparacion de 2-halo piridinas Expired ES8200345A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP80100207A EP0032516B1 (en) 1980-01-16 1980-01-16 New 2-halo-pyridines, their production and pharmaceutical compositions

Publications (2)

Publication Number Publication Date
ES498510A0 ES498510A0 (es) 1981-11-16
ES8200345A1 true ES8200345A1 (es) 1981-11-16

Family

ID=8186571

Family Applications (4)

Application Number Title Priority Date Filing Date
ES498510A Expired ES8200345A1 (es) 1980-01-16 1981-01-14 Procedimiento para la preparacion de 2-halo piridinas
ES498507A Expired ES8206480A1 (es) 1980-01-16 1981-01-14 Procedimiento para la preparacion de 2-halo piridinas
ES498509A Granted ES498509A0 (es) 1980-01-16 1981-01-14 Procedimiento para la preparacion de 2-halo piridinas
ES498508A Expired ES8200343A1 (es) 1980-01-16 1981-01-14 Procedimiento para la preparacion de 2-halo piridinas

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES498507A Expired ES8206480A1 (es) 1980-01-16 1981-01-14 Procedimiento para la preparacion de 2-halo piridinas
ES498509A Granted ES498509A0 (es) 1980-01-16 1981-01-14 Procedimiento para la preparacion de 2-halo piridinas
ES498508A Expired ES8200343A1 (es) 1980-01-16 1981-01-14 Procedimiento para la preparacion de 2-halo piridinas

Country Status (7)

Country Link
US (2) US4614833A (es)
EP (1) EP0032516B1 (es)
JP (1) JPS56120668A (es)
AT (1) ATE7295T1 (es)
DE (1) DE3067662D1 (es)
ES (4) ES8200345A1 (es)
PT (1) PT72354B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83978A (en) * 1986-09-26 1992-05-25 Ciba Geigy Process and compositions containing dihalopyridine derivatives for protecting plants against diseases,certain such novel derivatives and their preparation
DE3839332A1 (de) * 1988-11-22 1990-05-23 Bayer Ag Verfahren zur herstellung von substituierten 2-chlorpyridinen
ZA931855B (en) * 1992-03-20 1993-10-05 Lonza Ag A process for producing aromatic, nitrogen containing, heterocyclic carboxylic acid chlorides
IL105244A (en) * 1993-03-31 2003-07-31 Dpharm Ltd Prodrugs with enhanced penetration into cells
US5565413A (en) * 1994-12-06 1996-10-15 Zeneca Limited Substituted pyridyl phenyl ketone herbicides
JP4176150B2 (ja) * 1996-10-30 2008-11-05 塩野義製薬株式会社 グルタミン酸放出阻害剤および新規化合物
AP1286A (en) * 2000-07-05 2004-06-26 Ishihara Sangyo Kaisha Benzoylpyridine derivative or its salt, Fungicide containing it as an active ingredient, its production process and intermediate for producing it.
AR029289A1 (es) * 2000-07-05 2003-06-18 Ishihara Sangyo Kaisha Derivado de benzoilpiridina o su sal, fungicida que lo contiene como un ingrediente activo, su proceso de produccion e intermediario para producirlo
KR101163242B1 (ko) * 2003-10-31 2012-07-05 이시하라 산교 가부시끼가이샤 살균제 조성물 및 식물 병해의 방제 방법
CN100581362C (zh) * 2003-10-31 2010-01-20 石原产业株式会社 杀菌剂组合物和植物病害的防除方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3467662A (en) * 1967-10-05 1969-09-16 Sandoz Ag 1-para-chlorophenyl-3-hydrazino - 1,5,6,7,8,8a-hexahydroimidazo(1,5-a)pyridine and process for its preparation
GB1170680A (en) * 1967-12-21 1969-11-12 Allen & Hanburys Ltd Novel Pyridine Derivatives
AT332878B (de) * 1971-12-09 1976-10-25 Degussa Verfahren zur herstellung von neuen 6-aza-3h-1,4- benzodiazepinen, deren optischen isomeren und deren salzen
AT321303B (de) * 1972-05-10 1975-03-25 Degussa Verfahren zur Herstellung von neuen 2-Benzoyl-3-amino-pyridin-Verbindungen und deren Salzen
AT320649B (de) * 1972-05-10 1975-02-25 Degussa Verfahren zur Herstellung von neuen 2-Benzoyl-3-aminopyridin-Verbindungen und deren Salzen
GB1403487A (en) * 1972-07-21 1975-08-28 Yoshitomi Pharmaceutical Heterocyclic substituted alkanoic acids and derivatives
DE2364636C2 (de) * 1973-12-24 1982-11-04 Degussa Ag, 6000 Frankfurt Verfahren zur Herstellung von 2-Benzoyl-6-chlor-3-nitro-pyridinen
US4304941A (en) * 1980-08-01 1981-12-08 Hoechst Roussel Pharmaceuticals, Inc. Method of preparing poly-substituted acylbenzenes

Also Published As

Publication number Publication date
DE3067662D1 (en) 1984-06-07
ES498507A0 (es) 1982-08-01
EP0032516B1 (en) 1984-05-02
PT72354A (en) 1981-02-01
ES498508A0 (es) 1981-11-16
US4614833A (en) 1986-09-30
ES498510A0 (es) 1981-11-16
ES8200343A1 (es) 1981-11-16
PT72354B (en) 1981-12-18
ES8200344A1 (es) 1981-11-16
ES498509A0 (es) 1981-11-16
US4736037A (en) 1988-04-05
ES8206480A1 (es) 1982-08-01
JPS56120668A (en) 1981-09-22
EP0032516A1 (en) 1981-07-29
ATE7295T1 (de) 1984-05-15

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