ES8106737A1 - Un procedimiento para la preparacion de nuevos compuestos oligolipidos. - Google Patents
Un procedimiento para la preparacion de nuevos compuestos oligolipidos.Info
- Publication number
- ES8106737A1 ES8106737A1 ES493846A ES493846A ES8106737A1 ES 8106737 A1 ES8106737 A1 ES 8106737A1 ES 493846 A ES493846 A ES 493846A ES 493846 A ES493846 A ES 493846A ES 8106737 A1 ES8106737 A1 ES 8106737A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- beta
- immunological adjuvant
- thio
- glycolipid compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000568 immunological adjuvant Substances 0.000 title abstract 2
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical class O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 title 1
- JUSMHIGDXPKSID-PHYPRBDBSA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-sulfanyloxane-3,4,5-triol Chemical compound OC[C@H]1O[C@@H](S)[C@H](O)[C@@H](O)[C@H]1O JUSMHIGDXPKSID-PHYPRBDBSA-N 0.000 abstract 1
- QGXQUPXAQKVWCR-XLOQQCSPSA-N (2s,3r,4s,5r,6r)-2-[(2r,3s,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-sulfanyloxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](S)[C@H](O)[C@H]1O QGXQUPXAQKVWCR-XLOQQCSPSA-N 0.000 abstract 1
- -1 2-(1-adamantyl)ethyl Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
- C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/062,586 US4259324A (en) | 1979-07-31 | 1979-07-31 | Immunologic adjuvant thio glycoside compounds and compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES493846A0 ES493846A0 (es) | 1981-09-01 |
| ES8106737A1 true ES8106737A1 (es) | 1981-09-01 |
Family
ID=22043455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES493846A Expired ES8106737A1 (es) | 1979-07-31 | 1980-07-30 | Un procedimiento para la preparacion de nuevos compuestos oligolipidos. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4259324A (en:Method) |
| EP (1) | EP0023865A3 (en:Method) |
| JP (1) | JPS5653698A (en:Method) |
| AU (1) | AU6091280A (en:Method) |
| CA (1) | CA1159820A (en:Method) |
| DK (1) | DK328580A (en:Method) |
| ES (1) | ES8106737A1 (en:Method) |
| GR (1) | GR69627B (en:Method) |
| PT (1) | PT71624B (en:Method) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4431638A (en) * | 1982-10-25 | 1984-02-14 | American Cyanamid Company | Poly-cation salts of bis(or tris)[4-0-monohexose-thio]-arylene sulfate derivatives |
| US4435387A (en) | 1982-10-25 | 1984-03-06 | American Cyanamid Company | Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives |
| US4652637A (en) * | 1985-11-25 | 1987-03-24 | Merck & Co., Inc. | Steroidal glycolipids |
| DE3688364T2 (de) | 1985-11-25 | 1993-11-25 | Merck & Co Inc | Steroidische Glycolipide als Immunstimulatoren. |
| US4652553A (en) * | 1985-11-25 | 1987-03-24 | Merck & Co., Inc. | Steroidal glycolipids as host resistance stimulators |
| US5019568A (en) * | 1987-06-18 | 1991-05-28 | Merck & Co., Inc. | Steroidal glycolipids as host resistance stimulators against viral infection |
| US4970199A (en) * | 1987-06-18 | 1990-11-13 | Merck & Co., Inc. | Steroidal glycolipids as host resistance stimulators against viral infection |
| US4942154A (en) * | 1987-06-18 | 1990-07-17 | Merck & Co., Inc. | Steroidal glycolipids as host resistance stimulators against viral infection |
| US5055562A (en) * | 1988-02-01 | 1991-10-08 | Biomira, Inc. | Fluorocarbon chain-containing antigenic conjugates |
| US5695738A (en) * | 1995-06-15 | 1997-12-09 | Glycomed Incorporated | Steroidal C-glycosides |
| US6656481B1 (en) | 1996-09-06 | 2003-12-02 | Mitsubishi Chemical Corporation | Vaccinal preparations |
| JP4532618B2 (ja) * | 1999-02-25 | 2010-08-25 | 株式会社グライコメディクス | 新規糖鎖プライマー |
| AU2004228631B2 (en) | 2003-04-02 | 2010-12-02 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Cholesterol-containing compounds and their use as immunogens against Borrelia burgdorferi |
| DE102004054545A1 (de) * | 2004-09-16 | 2006-04-06 | Max-Delbrück-Centrum für Molekulare Medizin | Änderung des Beladungszustandes von MHC-Molekülen |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4189471A (en) * | 1978-07-11 | 1980-02-19 | Merck & Co., Inc. | Immunologic glycolipid adjuvants |
| US4229441A (en) * | 1978-12-01 | 1980-10-21 | Merck & Co., Inc. | Immunologic adjuvant |
-
1979
- 1979-07-31 US US06/062,586 patent/US4259324A/en not_active Expired - Lifetime
-
1980
- 1980-07-25 GR GR62546A patent/GR69627B/el unknown
- 1980-07-30 ES ES493846A patent/ES8106737A1/es not_active Expired
- 1980-07-30 PT PT71624A patent/PT71624B/pt unknown
- 1980-07-30 EP EP80401125A patent/EP0023865A3/en not_active Withdrawn
- 1980-07-30 AU AU60912/80A patent/AU6091280A/en not_active Abandoned
- 1980-07-30 CA CA000357374A patent/CA1159820A/en not_active Expired
- 1980-07-30 DK DK328580A patent/DK328580A/da unknown
- 1980-07-31 JP JP10445280A patent/JPS5653698A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PT71624A (en) | 1980-08-01 |
| AU6091280A (en) | 1981-02-05 |
| EP0023865A3 (en) | 1981-04-08 |
| DK328580A (da) | 1981-02-01 |
| ES493846A0 (es) | 1981-09-01 |
| JPS5653698A (en) | 1981-05-13 |
| CA1159820A (en) | 1984-01-03 |
| GR69627B (en:Method) | 1982-07-06 |
| PT71624B (en) | 1982-03-17 |
| US4259324A (en) | 1981-03-31 |
| EP0023865A2 (en) | 1981-02-11 |
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