GB2007973A - Lipogenesis inhibitors - Google Patents

Lipogenesis inhibitors

Info

Publication number
GB2007973A
GB2007973A GB7828225A GB7828225A GB2007973A GB 2007973 A GB2007973 A GB 2007973A GB 7828225 A GB7828225 A GB 7828225A GB 7828225 A GB7828225 A GB 7828225A GB 2007973 A GB2007973 A GB 2007973A
Authority
GB
United Kingdom
Prior art keywords
formula
alkoxy
hydroxyl
image
lipogenesis inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7828225A
Other versions
GB2007973B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shell Internationale Research Maatschappij BV
Original Assignee
Shell Internationale Research Maatschappij BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shell Internationale Research Maatschappij BV filed Critical Shell Internationale Research Maatschappij BV
Publication of GB2007973A publication Critical patent/GB2007973A/en
Application granted granted Critical
Publication of GB2007973B publication Critical patent/GB2007973B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/008—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with tri- or tetrahalomethyl compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compositions comprising a 5-R- or 6-R-benzofuran derivative of formula:- <IMAGE> wherein R is C3-C6cycloalkyl, C4-C8 alkyl or alkoxy, optionally substituted phenyl, phenoxy, benzyl or benzoyl, and R<1> is hydroxyl C1-C4 alkoxy, benzyloxy, alkenyloxy, alkynyloxy or cycloalkoxy, or of formula:- <IMAGE> wherein R is as in the former formula and R<1> is as in the former formula or is allylamino, are lipogenesis inhibitors in warm-blooded animals. Compounds of both formulae are claimed, except those in which simultaneously R is 5-phenyl and R<1> is hydroxyl or ethoxy, together with processes for their preparation.
GB7828225A 1977-06-30 1978-06-28 Lipogenesis inhibitors Expired GB2007973B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81164777A 1977-06-30 1977-06-30
US81789877A 1977-07-21 1977-07-21

Publications (2)

Publication Number Publication Date
GB2007973A true GB2007973A (en) 1979-05-31
GB2007973B GB2007973B (en) 1982-04-21

Family

ID=27123512

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7828225A Expired GB2007973B (en) 1977-06-30 1978-06-28 Lipogenesis inhibitors

Country Status (9)

Country Link
AU (1) AU520682B2 (en)
DD (1) DD141023A5 (en)
DE (1) DE2828396A1 (en)
DK (1) DK292678A (en)
FR (1) FR2401146A1 (en)
GB (1) GB2007973B (en)
IT (1) IT1113147B (en)
NL (1) NL7806944A (en)
SE (1) SE7807338L (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0019955A1 (en) * 1979-05-16 1980-12-10 Shell Internationale Researchmaatschappij B.V. Benzofurancarboxylic acid derivatives, their preparation and their inclusion in lipogenesis inhibiting compositions
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
US4663347A (en) * 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4822803A (en) * 1983-10-31 1989-04-18 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
US4933351A (en) * 1983-10-31 1990-06-12 Merck Frosst Canada, Inc. Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4229467A (en) * 1979-08-16 1980-10-21 Richardson-Merrell Inc. Alkoxy benzofuran carboxylic acids and salts and esters thereof as hypolipidemic agents
JP3093507B2 (en) * 1993-02-15 2000-10-03 キヤノン株式会社 Liquid crystal compound, liquid crystal composition containing the same, liquid crystal element having the same, display method and display device using them

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0019955A1 (en) * 1979-05-16 1980-12-10 Shell Internationale Researchmaatschappij B.V. Benzofurancarboxylic acid derivatives, their preparation and their inclusion in lipogenesis inhibiting compositions
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
US4663347A (en) * 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4822803A (en) * 1983-10-31 1989-04-18 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
US4933351A (en) * 1983-10-31 1990-06-12 Merck Frosst Canada, Inc. Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis

Also Published As

Publication number Publication date
DD141023A5 (en) 1980-04-09
AU520682B2 (en) 1982-02-18
FR2401146A1 (en) 1979-03-23
IT7825091A0 (en) 1978-06-28
SE7807338L (en) 1978-12-31
FR2401146B1 (en) 1983-03-18
GB2007973B (en) 1982-04-21
DK292678A (en) 1978-12-31
NL7806944A (en) 1979-01-03
IT1113147B (en) 1986-01-20
DE2828396A1 (en) 1979-01-11
AU3751578A (en) 1980-01-03

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee