ES8105323A1 - Un procedimiento para la preparacion de derivados del acido clarulanico - Google Patents

Un procedimiento para la preparacion de derivados del acido clarulanico

Info

Publication number
ES8105323A1
ES8105323A1 ES491578A ES491578A ES8105323A1 ES 8105323 A1 ES8105323 A1 ES 8105323A1 ES 491578 A ES491578 A ES 491578A ES 491578 A ES491578 A ES 491578A ES 8105323 A1 ES8105323 A1 ES 8105323A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
acid derivatives
clavulanic acid
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491578A
Other languages
English (en)
Other versions
ES491578A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES491578A0 publication Critical patent/ES491578A0/es
Publication of ES8105323A1 publication Critical patent/ES8105323A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE ACIDO CLAVULANICO. CONSISTE EN HACER REACCIONAR UN ESTER ESCINDIBLE DE UN COMPUESTO (I) CON UN TIOLATO DE UN TIOL DE FORMULA HS-CH=CH-NH-CO-R, PARA PRODUCIR UN ESTER ESCINDIBLE DEL COMPUESTO (II). A CONTINUACION, Y OPCIONALMENTE, SE REALIZA UNA O MAS DE LAS SIGUIENTES ETAPAS: 1. OXIDAR EL ATOMO DE AZUFRE (X) A UN GRUPO SO O SO2. 2. SEPARAR EL ESTER ESCINDIBLE. 3. CONVERTIR EL COMPUESTO (II) EN UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES O EN UNO DE SUS ESTERES HIDROLIZABLES <<IN VIVO>>. 4. CONVERTIR UNA SAL DEL COMPUESTO II EN EL ACIDO LIBRE. 5. HOMERIZAR EL DOBLE ENLACE. *FORMULA* AGENTES INHIBIDORES DE LA BETA-LACTAMASA Y ANTIBACTERIANOS. N
ES491578A 1979-05-17 1980-05-16 Un procedimiento para la preparacion de derivados del acido clarulanico Expired ES8105323A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7917210 1979-05-17

Publications (2)

Publication Number Publication Date
ES491578A0 ES491578A0 (es) 1981-05-16
ES8105323A1 true ES8105323A1 (es) 1981-05-16

Family

ID=10505223

Family Applications (1)

Application Number Title Priority Date Filing Date
ES491578A Expired ES8105323A1 (es) 1979-05-17 1980-05-16 Un procedimiento para la preparacion de derivados del acido clarulanico

Country Status (14)

Country Link
US (1) US4372962A (es)
EP (1) EP0019457B1 (es)
JP (1) JPS55157587A (es)
AT (1) ATE6514T1 (es)
AU (1) AU5850380A (es)
DE (1) DE3066808D1 (es)
DK (1) DK215680A (es)
ES (1) ES8105323A1 (es)
FI (1) FI801585A (es)
GR (1) GR68459B (es)
IL (1) IL60056A0 (es)
NO (1) NO801474L (es)
NZ (1) NZ193687A (es)
ZA (1) ZA802913B (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL50080A (en) * 1975-07-29 1979-07-25 Beecham Group Ltd 4-oxa-1-azabicyclo(3.2.0)heptan-7-one-2-car boxylic acid derivatives and their preparation
PT66071B (en) * 1976-01-31 1978-06-23 Beecham Group Ltd Clavulanic acid thioethers
DK86277A (da) * 1976-02-27 1977-08-28 Glaxo Lab Ltd Fremgangsmade til fremstilling af clavulamsyrederivater
US4215128A (en) * 1977-09-20 1980-07-29 Beecham Group Limited Clavulanic acid derivatives their preparation and use

Also Published As

Publication number Publication date
IL60056A0 (en) 1980-07-31
NZ193687A (en) 1982-12-21
EP0019457A2 (en) 1980-11-26
NO801474L (no) 1980-11-18
EP0019457B1 (en) 1984-03-07
GR68459B (es) 1981-12-30
JPS55157587A (en) 1980-12-08
FI801585A (fi) 1980-11-18
EP0019457A3 (en) 1981-01-28
ZA802913B (en) 1981-05-27
ES491578A0 (es) 1981-05-16
DK215680A (da) 1981-01-20
DE3066808D1 (en) 1984-04-12
US4372962A (en) 1983-02-08
AU5850380A (en) 1980-11-20
ATE6514T1 (de) 1984-03-15

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