ES8104310A1 - Procedimiento de preparacion de ergotamina y de alcaloides del grupo ergotoxina - Google Patents
Procedimiento de preparacion de ergotamina y de alcaloides del grupo ergotoxinaInfo
- Publication number
- ES8104310A1 ES8104310A1 ES493272A ES493272A ES8104310A1 ES 8104310 A1 ES8104310 A1 ES 8104310A1 ES 493272 A ES493272 A ES 493272A ES 493272 A ES493272 A ES 493272A ES 8104310 A1 ES8104310 A1 ES 8104310A1
- Authority
- ES
- Spain
- Prior art keywords
- solution
- alkaloids
- acetone
- ergotoxine
- ergotamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 title abstract 2
- 229960004943 ergotamine Drugs 0.000 title abstract 2
- XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 6
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 229930013930 alkaloid Natural products 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical compound [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XLMJRFCCCWFQRE-SJRQCXNHSA-N ecboline Chemical group C([C@H]1[C@]2(O)O3)CCN1C(=O)CN2C(=O)[C@]3(C(C)C)NC(=O)[C@@H](CN(C)[C@@H]1C2)C=C1C1=C3C2=CNC3=CC=C1 XLMJRFCCCWFQRE-SJRQCXNHSA-N 0.000 abstract 1
- 238000001033 granulometry Methods 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 239000000049 pigment Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/02—Ergot alkaloids of the cyclic peptide type
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7917860A FR2460955A1 (fr) | 1979-07-10 | 1979-07-10 | Procede de preparation de l'ergotamine et des alcaloides du groupe ergotoxine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES493272A0 ES493272A0 (es) | 1981-04-16 |
| ES8104310A1 true ES8104310A1 (es) | 1981-04-16 |
Family
ID=9227715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES493272A Expired ES8104310A1 (es) | 1979-07-10 | 1980-07-10 | Procedimiento de preparacion de ergotamina y de alcaloides del grupo ergotoxina |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0022418B1 (https=) |
| AT (1) | ATE3296T1 (https=) |
| DE (1) | DE3063118D1 (https=) |
| ES (1) | ES8104310A1 (https=) |
| FR (1) | FR2460955A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003074526A2 (en) * | 2002-02-28 | 2003-09-12 | Mallinckrodt Inc. | Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography |
| JP2007523174A (ja) * | 2004-02-20 | 2007-08-16 | イヴァックス ファーマシューティカルズ エス．アール．オー． | 麦角から麦角アルカロイド類を単離する方法 |
| DE102010060382B4 (de) | 2010-11-05 | 2013-05-29 | Bundesanstalt für Materialforschung und -Prüfung (BAM) | Analysenverfahren zur Isolierung von Mykotoxinen mit einer Ergolin-Grundstruktur, insbesondere von Ergotalkaloiden |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE697760C (de) * | 1937-12-09 | 1940-10-22 | Kali Chemie Akt Ges | Verfahren zur Gewinnung der grossen Gesamtalkaloide des Mutterkorns |
| FR2089081A5 (https=) * | 1970-04-02 | 1972-01-07 | Lek Tovarna Farmacevtskih |
-
1979
- 1979-07-10 FR FR7917860A patent/FR2460955A1/fr active Granted
-
1980
- 1980-07-09 AT AT80401033T patent/ATE3296T1/de active
- 1980-07-09 EP EP80401033A patent/EP0022418B1/fr not_active Expired
- 1980-07-09 DE DE8080401033T patent/DE3063118D1/de not_active Expired
- 1980-07-10 ES ES493272A patent/ES8104310A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3063118D1 (en) | 1983-06-16 |
| ES493272A0 (es) | 1981-04-16 |
| ATE3296T1 (de) | 1983-05-15 |
| EP0022418A1 (fr) | 1981-01-14 |
| FR2460955B1 (https=) | 1982-11-05 |
| EP0022418B1 (fr) | 1983-05-11 |
| FR2460955A1 (fr) | 1981-01-30 |
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