ES8102805A1 - Procedimiento mejorado para purificar polisacaridos capsula-res - Google Patents

Procedimiento mejorado para purificar polisacaridos capsula-res

Info

Publication number
ES8102805A1
ES8102805A1 ES489694A ES489694A ES8102805A1 ES 8102805 A1 ES8102805 A1 ES 8102805A1 ES 489694 A ES489694 A ES 489694A ES 489694 A ES489694 A ES 489694A ES 8102805 A1 ES8102805 A1 ES 8102805A1
Authority
ES
Spain
Prior art keywords
stabilization
capsular polysaccharides
lyophilization
capsular polysaccharide
capsular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES489694A
Other languages
English (en)
Other versions
ES489694A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES8102805A1 publication Critical patent/ES8102805A1/es
Publication of ES489694A0 publication Critical patent/ES489694A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Abstract

PROCEDIMIENTO PARA MANTENER LA ESTRUCTURA NATIVA DE LOS POLISACARIDOS NEUMOCOCICOS MULTIVALENTES DEL TIPO 19 DURANTE SU PURIFICACION. SE PRETENDE QUE LA MOLECULA DEL TIPO 19 NO SE DESPOLIMERICE DURANTE LA LIOFILIZACION Y SE MANTEGA POR ENCIMA DE LOS VALORES ACEPTABLES DE LOS ESTANDARES KD. ESTE PROCEDIMIENTO DONDE LOS POLISACARIDOS CAPSULARES SE PRODUCEN POR FERMENTACION, SE AISLAN Y SE LIOFILIZAN, SE CARACTERIZA PORQUE ANTES DE LA ETAPA DE LIOFILIZACION SE LES AÑADE UNA SUSTANCIA ANFOTERA, TAL COMO LA GLICINA, ALANINA O VALAINA Y OTROS AMINOACIDOS COMO ALBUMINA, GELATINA, PEPTONA, CASEINA,HIDROLIZADOS DE PROTEINA Y OTRAS PROTEINAS EN UNA RELACION VOLUMETRICA DEL 0,1 AL 0,2 POR 100, QUE ACTUA COMO ESTABILIZANTE.
ES489694A 1979-03-19 1980-03-18 Procedimiento mejorado para purificar polisacaridos capsula-res Granted ES489694A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/021,861 US4221906A (en) 1979-03-19 1979-03-19 Stabilization of pneumococcal polysaccharides

Publications (2)

Publication Number Publication Date
ES8102805A1 true ES8102805A1 (es) 1981-02-16
ES489694A0 ES489694A0 (es) 1981-02-16

Family

ID=21806554

Family Applications (1)

Application Number Title Priority Date Filing Date
ES489694A Granted ES489694A0 (es) 1979-03-19 1980-03-18 Procedimiento mejorado para purificar polisacaridos capsula-res

Country Status (8)

Country Link
US (1) US4221906A (es)
EP (1) EP0017322B1 (es)
JP (1) JPS55159799A (es)
AR (1) AR220822A1 (es)
AT (1) ATE2114T1 (es)
CA (1) CA1135643A (es)
DE (1) DE3061466D1 (es)
ES (1) ES489694A0 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2510606A1 (fr) * 1981-07-30 1983-02-04 Berri Balzac Procede d'obtention de polyosides capsulaires, polyosides capsulaires ainsi obtenus et leur application a la preparation de vaccins
BE889979A (fr) * 1981-08-14 1982-02-15 Smith Kline Rit Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation
US4542123A (en) * 1982-01-11 1985-09-17 Massachusetts Institute Of Technology Composition and method for increasing brain tyrosine levels
US4600583A (en) * 1982-09-07 1986-07-15 Tetra Consultants Inc. Pharmaceutical compositions
DE3601922A1 (de) * 1986-01-23 1987-07-30 Behringwerke Ag Stabilisiertes virus-antigen, verfahren zu seiner herstellung und seine verwendung
FR2619122B1 (fr) * 1987-08-03 1990-03-09 Pasteur Institut Procede d'obtention de polyosides capsulaires de staphylocoques, polyosides obtenus, applications de ces polyosides et souches pour la mise en oeuvre du procede
CA2059693C (en) * 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
CA2059692C (en) * 1991-01-28 2004-11-16 Peter J. Kniskern Pneumoccoccal polysaccharide conjugate vaccine
EP2436700B8 (en) * 2007-03-23 2018-08-01 Wyeth LLC Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides
PL2385981T3 (pl) * 2008-12-18 2020-01-31 Wyeth Llc Sposób kontroli masy cząsteczkowej polisacharydów streptococcus pneumoniae z zastosowaniem węgla
SI2379734T1 (en) * 2008-12-18 2018-05-31 Wyeth Llc PROCEDURE FOR THE CONTROL OF THE SEROTYPE 19A STREPTOCOCCUS PNEUMONIAE POLYESAHARIDE MOLECULAR MASS
US11058757B2 (en) 2016-03-31 2021-07-13 Pogona, LLC Saccharide-polypeptide conjugate compositions and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2528972A (en) * 1947-05-15 1950-11-07 Western Reserve University Prophylactic toxoid compound and method of making same
US3436311A (en) * 1966-02-28 1969-04-01 Pillsbury Co Fungal polysaccharide composition and method for making same
US4043952A (en) * 1975-05-09 1977-08-23 National Starch And Chemical Corporation Surface treatment process for improving dispersibility of an absorbent composition, and product thereof
US4090919A (en) * 1976-01-29 1978-05-23 Tanabe Seiyaku Co., Ltd. Water-insoluble tannin preparation for immobilization of proteins

Also Published As

Publication number Publication date
DE3061466D1 (en) 1983-02-03
US4221906A (en) 1980-09-09
EP0017322B1 (en) 1982-12-29
ATE2114T1 (de) 1983-01-15
CA1135643A (en) 1982-11-16
JPS55159799A (en) 1980-12-12
JPH0236236B2 (es) 1990-08-16
ES489694A0 (es) 1981-02-16
AR220822A1 (es) 1980-11-28
EP0017322A1 (en) 1980-10-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010217