GB2001995A - An immunostimulant, a process for preparing it, and compositions containing it - Google Patents

An immunostimulant, a process for preparing it, and compositions containing it

Info

Publication number
GB2001995A
GB2001995A GB7831772A GB7831772A GB2001995A GB 2001995 A GB2001995 A GB 2001995A GB 7831772 A GB7831772 A GB 7831772A GB 7831772 A GB7831772 A GB 7831772A GB 2001995 A GB2001995 A GB 2001995A
Authority
GB
United Kingdom
Prior art keywords
immunostimulant
water
substance
soluble
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB7831772A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Publication of GB2001995A publication Critical patent/GB2001995A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

An immunostimulant substance, denoted 34129 RP, is obtained from delipidated cells of Streptomyces stimulosus DS 25556 (NRRL 5776), by a process which comprises subjecting these delipidated cells to repeated autolysis, thereafter fractionating the water-soluble portion of the autolysis product by ultrafiltration to obtain substances whose molecular weight is 2000 to 20,000, and isolating the water- soluble substance 34129RP thus obtained after lyophilization of the solution. The immunostimulant substance is water-soluble, and can be administered by numerous routes to humans and to animals, preferably in the form of conventional pharmaceutical formulations. The immunostimulant, which has an elementary analysis; C40.4-41.1%; H 6.7-6.9%, N 8.0-10.6%, comprises alamine (5 to 7%), glutamic acid (7 to 10%), glycine (2.5 to 4%), alpha , alpha , diaminopimelic acid (5 to 8%), N-acetyl- glucosamine (5 to 10%) and muramic acid (5 to 10%).
GB7831772A 1977-08-04 1978-07-31 An immunostimulant, a process for preparing it, and compositions containing it Withdrawn GB2001995A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7724092A FR2399437A1 (en) 1977-08-04 1977-08-04 NEW IMMUNOSTIMULANT SUBSTANCE, ITS PREPARATION PROCESS AND THE COMPOSITIONS CONTAINING IT

Publications (1)

Publication Number Publication Date
GB2001995A true GB2001995A (en) 1979-02-14

Family

ID=9194245

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7831772A Withdrawn GB2001995A (en) 1977-08-04 1978-07-31 An immunostimulant, a process for preparing it, and compositions containing it

Country Status (6)

Country Link
JP (1) JPS5427502A (en)
BE (1) BE869058A (en)
DE (1) DE2833799A1 (en)
FR (1) FR2399437A1 (en)
GB (1) GB2001995A (en)
NL (1) NL7807938A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2466455A2 (en) * 1979-10-05 1981-04-10 Anvar Immunostimulant and adjuvant N-acyl-peptide derivs. - produced by N-acylation of peptides from streptomyces stimulosus water-soluble extract (BE 17.4.80)
GB2033906B (en) * 1978-10-19 1982-12-01 Anvar Water-soluble compounds derived from extracts of streptomyces stimulosus process for their production and compositions containing them
JPS5766836U (en) * 1980-10-07 1982-04-21

Also Published As

Publication number Publication date
BE869058A (en) 1979-01-17
NL7807938A (en) 1979-02-06
DE2833799A1 (en) 1979-02-15
FR2399437A1 (en) 1979-03-02
JPS5427502A (en) 1979-03-01

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)