GB2001995A - An immunostimulant, a process for preparing it, and compositions containing it - Google Patents
An immunostimulant, a process for preparing it, and compositions containing itInfo
- Publication number
- GB2001995A GB2001995A GB7831772A GB7831772A GB2001995A GB 2001995 A GB2001995 A GB 2001995A GB 7831772 A GB7831772 A GB 7831772A GB 7831772 A GB7831772 A GB 7831772A GB 2001995 A GB2001995 A GB 2001995A
- Authority
- GB
- United Kingdom
- Prior art keywords
- immunostimulant
- water
- substance
- soluble
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
An immunostimulant substance, denoted 34129 RP, is obtained from delipidated cells of Streptomyces stimulosus DS 25556 (NRRL 5776), by a process which comprises subjecting these delipidated cells to repeated autolysis, thereafter fractionating the water-soluble portion of the autolysis product by ultrafiltration to obtain substances whose molecular weight is 2000 to 20,000, and isolating the water- soluble substance 34129RP thus obtained after lyophilization of the solution. The immunostimulant substance is water-soluble, and can be administered by numerous routes to humans and to animals, preferably in the form of conventional pharmaceutical formulations. The immunostimulant, which has an elementary analysis; C40.4-41.1%; H 6.7-6.9%, N 8.0-10.6%, comprises alamine (5 to 7%), glutamic acid (7 to 10%), glycine (2.5 to 4%), alpha , alpha , diaminopimelic acid (5 to 8%), N-acetyl- glucosamine (5 to 10%) and muramic acid (5 to 10%).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7724092A FR2399437A1 (en) | 1977-08-04 | 1977-08-04 | NEW IMMUNOSTIMULANT SUBSTANCE, ITS PREPARATION PROCESS AND THE COMPOSITIONS CONTAINING IT |
Publications (1)
Publication Number | Publication Date |
---|---|
GB2001995A true GB2001995A (en) | 1979-02-14 |
Family
ID=9194245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7831772A Withdrawn GB2001995A (en) | 1977-08-04 | 1978-07-31 | An immunostimulant, a process for preparing it, and compositions containing it |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS5427502A (en) |
BE (1) | BE869058A (en) |
DE (1) | DE2833799A1 (en) |
FR (1) | FR2399437A1 (en) |
GB (1) | GB2001995A (en) |
NL (1) | NL7807938A (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2466455A2 (en) * | 1979-10-05 | 1981-04-10 | Anvar | Immunostimulant and adjuvant N-acyl-peptide derivs. - produced by N-acylation of peptides from streptomyces stimulosus water-soluble extract (BE 17.4.80) |
GB2033906B (en) * | 1978-10-19 | 1982-12-01 | Anvar | Water-soluble compounds derived from extracts of streptomyces stimulosus process for their production and compositions containing them |
JPS5766836U (en) * | 1980-10-07 | 1982-04-21 |
-
1977
- 1977-08-04 FR FR7724092A patent/FR2399437A1/en not_active Withdrawn
-
1978
- 1978-07-17 BE BE189329A patent/BE869058A/en unknown
- 1978-07-26 NL NL787807938A patent/NL7807938A/en not_active Application Discontinuation
- 1978-07-31 GB GB7831772A patent/GB2001995A/en not_active Withdrawn
- 1978-08-02 DE DE19782833799 patent/DE2833799A1/en active Pending
- 1978-08-04 JP JP9468578A patent/JPS5427502A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BE869058A (en) | 1979-01-17 |
NL7807938A (en) | 1979-02-06 |
DE2833799A1 (en) | 1979-02-15 |
FR2399437A1 (en) | 1979-03-02 |
JPS5427502A (en) | 1979-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |