ES8102552A1 - Un procedimiento para fabricar esteres de guayacilo - Google Patents

Un procedimiento para fabricar esteres de guayacilo

Info

Publication number
ES8102552A1
ES8102552A1 ES487115A ES487115A ES8102552A1 ES 8102552 A1 ES8102552 A1 ES 8102552A1 ES 487115 A ES487115 A ES 487115A ES 487115 A ES487115 A ES 487115A ES 8102552 A1 ES8102552 A1 ES 8102552A1
Authority
ES
Spain
Prior art keywords
beta
alpha
acid
obtaining
mercaptopropionylalanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES487115A
Other languages
English (en)
Other versions
ES487115A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of ES487115A0 publication Critical patent/ES487115A0/es
Publication of ES8102552A1 publication Critical patent/ES8102552A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA FABRICAR ESTERES DE GUAYACILO DE UN DERIVADO DE ACIDO MERCAPTOPROPIONICO. EL PROCEDIMIENTO COMPRENDE PROTEGER EL GRUPO SULFHIDRILO DEL ACIDO ALFA- O BETA-MERCAPTOPROPIONICO MEDIANTE UN GRUPO PROTECTOR, HALOGENAR EL ACIDO PARA OBTENER EL HALURO DE ACILO. POSTERIORMENTE SE CONDENSA EL HALURO DE ACILO CON GLICINA O ALANINA, OBTENIENDOSE ASI MERCAPTOPROPIONILGLICINA, SE HACE REACCIONAR ESTE COMPUESTO CON CLORO CARBONATO DE ISOBUTILO O DE ETILO,OBTENIENDOSE ASI EL CORRESPONDIENTE ANHIDRO. SE CONDENSA EL ANHIDRO CON GUAYACOL, OBTENIENDOSE ASI ESTER DE GUAYACILO DE MERCAPTOPROPIONILALAMINA; POR ULTIMO, SE ELIMINA EL GRUPO PROTECTOR DEL ESTER EN UN AMBIENTE ACIDO. ESTE COMPUESTO ES UTIL EN TERAPEUTICA COMO AGENTE MUCOLITICO.
ES487115A 1978-12-21 1979-12-20 Un procedimiento para fabricar esteres de guayacilo Expired ES8102552A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT52417/78A IT1111384B (it) 1978-12-21 1978-12-21 Guaiacil esteri di derivati dello acido mercaptopropionico procedimento per la loro preparazione e loro uso terapeutico

Publications (2)

Publication Number Publication Date
ES487115A0 ES487115A0 (es) 1981-01-16
ES8102552A1 true ES8102552A1 (es) 1981-01-16

Family

ID=11277059

Family Applications (1)

Application Number Title Priority Date Filing Date
ES487115A Expired ES8102552A1 (es) 1978-12-21 1979-12-20 Un procedimiento para fabricar esteres de guayacilo

Country Status (11)

Country Link
US (1) US4299842A (es)
EP (1) EP0013261B1 (es)
JP (1) JPS5587764A (es)
AR (1) AR226297A1 (es)
AT (1) ATE1901T1 (es)
CA (1) CA1137993A (es)
DE (1) DE2903615C2 (es)
DK (1) DK150506C (es)
ES (1) ES8102552A1 (es)
IL (1) IL58992A (es)
IT (1) IT1111384B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1143209B (it) * 1981-07-02 1986-10-22 Sigma Tau Ind Farmaceuti Esteri della 2-tenoilmercaptopropionil glicina con idrossibenzeni sostituiti procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1170861B (it) * 1981-03-31 1987-06-03 Sigma Tau Ind Farmaceuti Ester di mercaptoacil-carnitine procedimento per la loro preparazione e loro uso terapeutico
IE52884B1 (en) * 1981-05-11 1988-03-30 Sigma Tau Ind Farmaceuti 2-methoxyphenyl esters of n-substituted amino acids, their preparation and pharmaceutical use
FR2563218B1 (fr) * 1984-04-19 1986-06-20 Synthelabo Derives d'acide n-((chloro-2 phenyl)methylthio-3 oxo-1 propyl)-aminoacetique substitue en a, leur preparation et leur application en therapeutique
EP0161172A1 (fr) * 1984-04-19 1985-11-13 Synthelabo Dérivés d'acide n-(phenylmethylthio-3 oxo-1 propyl)-aminoacétique, leur préparation et leur application en thérapeutique
US5210266A (en) * 1987-12-03 1993-05-11 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
US5179125A (en) * 1987-12-03 1993-01-12 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
EP0318859A3 (en) * 1987-12-03 1990-08-16 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
WO2012058269A2 (en) * 2010-10-29 2012-05-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating cancer and other diseases
CN106380430A (zh) * 2016-09-05 2017-02-08 吉尔生化（上海）有限公司 一种3‑(三苯甲硫基)丙酸的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH451186A (de) * 1961-11-02 1968-05-15 Santen Phamarceutical Co Ltd Verfahren zur Herstellung von N-Mercaptopropionylglycin und dessen Derivaten
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
GB1583602A (en) * 1977-05-26 1981-01-28 Sterwin Ag N-acetyl-para-aminophenyl-n'-acetyl-amino-thioalkanoic acid ester derivatives

Also Published As

Publication number Publication date
DK547379A (da) 1980-06-22
IL58992A (en) 1984-01-31
ES487115A0 (es) 1981-01-16
IT1111384B (it) 1986-01-13
JPS5587764A (en) 1980-07-02
EP0013261A1 (en) 1980-07-09
DK150506C (da) 1987-10-26
US4299842A (en) 1981-11-10
AR226297A1 (es) 1982-06-30
JPS6326748B2 (es) 1988-05-31
DE2903615A1 (de) 1980-06-26
ATE1901T1 (de) 1982-12-15
IT7852417A0 (it) 1978-12-21
CA1137993A (en) 1982-12-21
DK150506B (da) 1987-03-16
IL58992A0 (en) 1980-03-31
DE2903615C2 (de) 1982-05-06
EP0013261B1 (en) 1982-12-01

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