ES8102549A1 - Procedimiento para la preparacion de esteres de salicilamida - Google Patents
Procedimiento para la preparacion de esteres de salicilamidaInfo
- Publication number
- ES8102549A1 ES8102549A1 ES489518A ES489518A ES8102549A1 ES 8102549 A1 ES8102549 A1 ES 8102549A1 ES 489518 A ES489518 A ES 489518A ES 489518 A ES489518 A ES 489518A ES 8102549 A1 ES8102549 A1 ES 8102549A1
- Authority
- ES
- Spain
- Prior art keywords
- acid
- esters
- salicylamide
- phenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical class NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229960000581 salicylamide Drugs 0.000 abstract 2
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 abstract 1
- JZFPYUNJRRFVQU-UHFFFAOYSA-N Niflumic acid Chemical compound OC(=O)C1=CC=CN=C1NC1=CC=CC(C(F)(F)F)=C1 JZFPYUNJRRFVQU-UHFFFAOYSA-N 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
- ARHWPKZXBHOEEE-UHFFFAOYSA-N alclofenac Chemical compound OC(=O)CC1=CC=C(OCC=C)C(Cl)=C1 ARHWPKZXBHOEEE-UHFFFAOYSA-N 0.000 abstract 1
- 229960005142 alclofenac Drugs 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 abstract 1
- 229960003512 nicotinic acid Drugs 0.000 abstract 1
- 239000011664 nicotinic acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE ESTERES DE SALICILAMIDA DE FORMULA: *FORMULA* DONDE R REPRESENTA DIVERSOS TIPOS DE RADICALES. SE CARACTERIZA PORQUE EL CLORURO DEL ACIDO DESEADO SE ADICIONA LENTAMENTE A UNA SALICILAMIDA Y LA MEZCLA DE REACCION SE CALIENTA A LA TEMPERATURA DE REACCION DESEADA, PROCEDIENDOSE DESPUES AL AISLAMIENTO DEL ETER RESULTANTE DE LA REACCION Y A SU PURIFICACION. ESTOS COMPUESTOS PRESENTAN EFECTOS ULCERANTES SOBRE LA MUCOSA GASTRICA, APARTE DE UNA ACCION ANTIINFLAMATORIA Y ANALGESICA. U
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21320/79A IT1113331B (it) | 1979-03-27 | 1979-03-27 | Esteri della salicilammide con attivita' terapeutica,procedimento per la loro preparazione e relative composizioni farmaceutiche |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8102549A1 true ES8102549A1 (es) | 1981-02-16 |
| ES489518A0 ES489518A0 (es) | 1981-02-16 |
Family
ID=11180059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES489518A Granted ES489518A0 (es) | 1979-03-27 | 1980-03-13 | Procedimiento para la preparacion de esteres de salicilamida |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4268685A (es) |
| EP (1) | EP0016460B1 (es) |
| JP (1) | JPS55147247A (es) |
| AR (1) | AR226555A1 (es) |
| AT (1) | ATE1381T1 (es) |
| BE (1) | BE882480A (es) |
| CA (1) | CA1134366A (es) |
| DE (1) | DE3060690D1 (es) |
| ES (1) | ES489518A0 (es) |
| FR (1) | FR2452479A1 (es) |
| IT (1) | IT1113331B (es) |
| ZA (1) | ZA801598B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101928227A (zh) * | 2009-12-16 | 2010-12-29 | 天津工业大学 | 6-甲氧基-2-萘乙酸与水杨酰苯胺类化合物的互联体前药制备方法及应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3313848A (en) * | 1964-06-18 | 1967-04-11 | Parke Davis & Co | Anthranilic acids and derivatives |
| IT1061780B (it) * | 1966-09-03 | 1983-04-30 | Italfarmaco Spa | Acido n 4 carbossifenil antrantiico suoi derivati e processo per la loro preparazione |
| GB1187259A (en) * | 1967-10-23 | 1970-04-08 | Hexachimie | New Aminoalkyl Esters of 2-Anilino-Nicotinic Acids and process for their manufacture |
| US3673243A (en) * | 1968-05-08 | 1972-06-27 | Sumitomo Chemical Co | Novel process for producing o-anilinophenylaliphatic acid derivatives |
| FR1601574A (en) * | 1968-12-02 | 1970-08-31 | Anthraniloylsalicylic acids | |
| US3657430A (en) * | 1969-06-25 | 1972-04-18 | Merck & Co Inc | Composition and methods for treating inflammation |
| US3652762A (en) * | 1970-04-14 | 1972-03-28 | Ciba Geigy Corp | Pharmaceutical compositions and methods employing substituted derivatives of 2-anilinophenylacetic acids and esters |
| JPS4725336U (es) * | 1971-04-14 | 1972-11-21 | ||
| JPS4930340A (es) * | 1972-07-12 | 1974-03-18 | ||
| US3778470A (en) * | 1972-08-23 | 1973-12-11 | A Sallman | Chemical intermediates for the production of substituted 2-anilinophenylacetic acids and esters |
| US4029815A (en) * | 1975-04-30 | 1977-06-14 | Schering Corporation | Anti-diarrheal anthranilic acids |
| JPS5220467A (en) * | 1975-08-11 | 1977-02-16 | Osaka Gas Co Ltd | Device for preventing cooling crushed substance from showing crystalli ne exposure |
| US4150137A (en) * | 1975-12-24 | 1979-04-17 | Hisamitsu Pharmaceutical Co. Inc. | Pyridylalkyl esters of 2-(p-isobutylphenyl)acetic acid and propionic acids and use |
| GB1518621A (en) * | 1976-02-20 | 1978-07-19 | Beecham Group Ltd | Analgesic composition |
| US4049699A (en) * | 1976-06-17 | 1977-09-20 | The Upjohn Company | Ibuprofen p-hydroxybenzaldehyde semicarbazone ester |
| US4049700A (en) * | 1976-06-17 | 1977-09-20 | The Upjohn Company | Ibuprofen p-hydroxyphenylurea ester |
| JPS53105445A (en) * | 1977-02-26 | 1978-09-13 | Hokuriku Pharmaceutical | Nn*33trifluoromethylphenyl* anthranylate alklyester derivative and process for preparing same |
-
1979
- 1979-03-27 IT IT21320/79A patent/IT1113331B/it active
-
1980
- 1980-03-12 US US06/129,660 patent/US4268685A/en not_active Expired - Lifetime
- 1980-03-13 ES ES489518A patent/ES489518A0/es active Granted
- 1980-03-19 ZA ZA00801598A patent/ZA801598B/xx unknown
- 1980-03-19 EP EP80101442A patent/EP0016460B1/en not_active Expired
- 1980-03-19 AT AT80101442T patent/ATE1381T1/de not_active IP Right Cessation
- 1980-03-19 DE DE8080101442T patent/DE3060690D1/de not_active Expired
- 1980-03-21 AR AR280400A patent/AR226555A1/es active
- 1980-03-26 FR FR8006681A patent/FR2452479A1/fr active Granted
- 1980-03-26 JP JP3764880A patent/JPS55147247A/ja active Pending
- 1980-03-26 CA CA000348495A patent/CA1134366A/en not_active Expired
- 1980-03-27 BE BE0/199990A patent/BE882480A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1134366A (en) | 1982-10-26 |
| DE3060690D1 (en) | 1982-09-16 |
| ZA801598B (en) | 1980-10-29 |
| BE882480A (fr) | 1980-07-16 |
| IT7921320A0 (it) | 1979-03-27 |
| FR2452479B1 (es) | 1982-12-31 |
| JPS55147247A (en) | 1980-11-17 |
| EP0016460A1 (en) | 1980-10-01 |
| ATE1381T1 (de) | 1982-08-15 |
| US4268685A (en) | 1981-05-19 |
| FR2452479A1 (fr) | 1980-10-24 |
| ES489518A0 (es) | 1981-02-16 |
| AR226555A1 (es) | 1982-07-30 |
| EP0016460B1 (en) | 1982-07-28 |
| IT1113331B (it) | 1986-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3385886A (en) | Phenyl propionic acids | |
| US3255241A (en) | (2-alkylidene acyl)phenoxy-and (2-alkylidene acyl)phenylmercaptocarboxylic acids | |
| AU544066B2 (en) | 2-(4-(diphenylmethyl)-1-piperazinyl)-acetic acids and their amides | |
| NO904022D0 (no) | Fremgangsmaate for fremstilling av nye n-aryl- og n-heteroarylamid- og -urinstoffderivater. | |
| ZA200206072B (en) | Aniline-derived ligands for the thyroid receptor. | |
| US3649679A (en) | Substituted phenylalkanoic acid derivatives ii | |
| JPS5587771A (en) | 1-phenylisoquinoline derivative | |
| AU2008263669A1 (en) | Novel derivatives of 3-phenyl acrylic acid activating PPAR-type receptors, method for preparing same and use thereof in cosmetic or pharmaceutical compositions | |
| ES8102549A1 (es) | Procedimiento para la preparacion de esteres de salicilamida | |
| US3402198A (en) | 2-(phenoxy), 2-(phenylthio) and 2-(anilino) substituted 2-alkylideneacetic acid derivatives | |
| US3927092A (en) | Amides of 2-{8 halophenoxy (or halophenylthio){9 -alkanoic acids | |
| US4440787A (en) | Compounds with antiinflammatory and analgesic activity, process for the preparation thereof and pharmaceutical compositions therefrom | |
| GB1515060A (en) | 3-hydroxymethylene-6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid esters | |
| AU2008263668A1 (en) | Novel derivatives of 3-phenyl propanoic acid activating PPAR-type receptors, method for preparing same and use thereof in cosmetic or pharmaceutical compositions | |
| CA2487450C (en) | (2s)-2-ethylphenylpropanoic acid derivatives | |
| IE35234L (en) | 2-(substituted phenyl) propionic acids | |
| WO2003011819A1 (en) | Butyric acid derivatives | |
| US4529737A (en) | Analgesic and anti-inflammatory arylalkanoic acid phthalidyl esters and pharmaceutical compositions thereof | |
| GB1465219A (en) | Process for the preparation of a phenyl alkonoic acid and its salts | |
| US4440786A (en) | Compounds with antiinflammatory and analgesic activity, process for the preparation thereof and pharmaceutical compositio ns therefrom | |
| DE2307038A1 (de) | Ester und amide von phenoxysubstituierten phenylessigsaeuren | |
| GB1263768A (en) | New substituted aryloxy- and arylthioacetic acids, esters and salts thereof, process for their production and compositions containing same | |
| JPS55130944A (en) | 1-(o-(2',6'-dichloroanilino)phenyl)-2,2-dimethoxyethylene, and its preparation | |
| JPS579757A (en) | Alpha-sulfonyl 2-fluoro-4-biphenylyl acetic acid derivative | |
| JPS5620582A (en) | Novel 2-benzothiazolinone derivative and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19960603 |