ES486871A1 - Procedimiento para la obtencion de 7,8,9,10-tetrahidrotieno-3,2-e-pirido-4,3-b-indoles - Google Patents

Procedimiento para la obtencion de 7,8,9,10-tetrahidrotieno-3,2-e-pirido-4,3-b-indoles

Info

Publication number
ES486871A1
ES486871A1 ES486871A ES486871A ES486871A1 ES 486871 A1 ES486871 A1 ES 486871A1 ES 486871 A ES486871 A ES 486871A ES 486871 A ES486871 A ES 486871A ES 486871 A1 ES486871 A1 ES 486871A1
Authority
ES
Spain
Prior art keywords
tetrahydrothieno
pyrido
indoles
preparation
medicaments containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES486871A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Troponwerke GmbH
Original Assignee
Troponwerke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6057189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES486871(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Troponwerke GmbH filed Critical Troponwerke GmbH
Publication of ES486871A1 publication Critical patent/ES486871A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procedimiento para la obtención de 7,8,9,10-tetra- hidrotieno[3,2-e]pirido[4,3-b] indoles de fórmula general (I) **(Fórmula)** donde R1, R2 y R3 son iguales o diferentes y significan hidrógeno, alquilo de cadena recta o ramificada, alquenilo o alquinilo, donde un grupo CH2, en caso dado, está intercambiado por un átomo de oxígeno o un átomo de nitrógeno insustituido o sustituido por alquilo inferior, y donde uno o varios átomo de hidrógeno pueden estar sustituidos por halógeno o hidroxi, o significan arilo o aralquilo, donde el anillo arilo, en caso dado, está sustituido por alquilo inferior o alcoxi, halógeno, hidroxilo o trifluormetilo, o significan cicloalquilo o cicloalquilalquilo.
ES486871A 1978-12-14 1979-12-13 Procedimiento para la obtencion de 7,8,9,10-tetrahidrotieno-3,2-e-pirido-4,3-b-indoles Expired ES486871A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782854014 DE2854014A1 (de) 1978-12-14 1978-12-14 7,8,9,10-tetrahydrothieno eckige klammer auf 3,2-e eckige klammer zu pyrido eckige klammer auf 4,3-b eckige klammer zu indole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
ES486871A1 true ES486871A1 (es) 1980-06-16

Family

ID=6057189

Family Applications (1)

Application Number Title Priority Date Filing Date
ES486871A Expired ES486871A1 (es) 1978-12-14 1979-12-13 Procedimiento para la obtencion de 7,8,9,10-tetrahidrotieno-3,2-e-pirido-4,3-b-indoles

Country Status (19)

Country Link
US (1) US4410536A (es)
EP (1) EP0012347B1 (es)
JP (1) JPS5585589A (es)
AT (1) ATE1384T1 (es)
AU (1) AU528706B2 (es)
CA (1) CA1134364A (es)
DD (1) DD147668A5 (es)
DE (2) DE2854014A1 (es)
DK (1) DK532179A (es)
EG (1) EG14087A (es)
ES (1) ES486871A1 (es)
FI (1) FI69078C (es)
GR (1) GR72729B (es)
HU (1) HU179325B (es)
IE (1) IE49471B1 (es)
IL (1) IL58918A0 (es)
NO (1) NO151366C (es)
PT (1) PT70545A (es)
ZA (1) ZA796770B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3311342A1 (de) * 1983-03-29 1984-10-04 Troponwerke GmbH & Co KG, 5000 Köln 7,8,9,10-tetrahydrothieno(3,2-e)pyrido(4,3-b) indole, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
EP0499337A1 (en) * 1991-02-14 1992-08-19 Yamanouchi Europe B.V. Use of tetra:hydro-thieno-pyrido-indole derivatives for the treatment of skin disorders
GB201704325D0 (en) * 2017-03-17 2017-05-03 Argonaut Therapeutics Ltd Compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2568M (fr) * 1962-01-10 1964-06-01 Hoffmann La Roche Agents contre la coagulation vasculaire.

Also Published As

Publication number Publication date
EG14087A (en) 1983-03-31
PT70545A (de) 1980-01-01
IL58918A0 (en) 1980-03-31
JPS5585589A (en) 1980-06-27
EP0012347A1 (de) 1980-06-25
DD147668A5 (de) 1981-04-15
ZA796770B (en) 1980-12-31
HU179325B (en) 1982-09-28
FI69078C (fi) 1985-12-10
NO151366C (no) 1985-03-27
DE2854014A1 (de) 1980-07-03
FI793889A (fi) 1980-06-15
IE49471B1 (en) 1985-10-16
NO151366B (no) 1984-12-17
FI69078B (fi) 1985-08-30
DK532179A (da) 1980-06-15
EP0012347B1 (de) 1982-07-28
US4410536A (en) 1983-10-18
JPS6330917B2 (es) 1988-06-21
ATE1384T1 (de) 1982-08-15
GR72729B (es) 1983-12-01
IE792415L (en) 1980-06-14
DE2963456D1 (en) 1982-09-16
CA1134364A (en) 1982-10-26
NO793794L (no) 1980-06-17
AU528706B2 (en) 1983-05-12
AU5363079A (en) 1980-06-19

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