ES482323A1 - Un procedimiento para preparar nuevos compuestos de cefem. - Google Patents
Un procedimiento para preparar nuevos compuestos de cefem.Info
- Publication number
- ES482323A1 ES482323A1 ES482323A ES482323A ES482323A1 ES 482323 A1 ES482323 A1 ES 482323A1 ES 482323 A ES482323 A ES 482323A ES 482323 A ES482323 A ES 482323A ES 482323 A1 ES482323 A1 ES 482323A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- alkyl
- processes
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Cephem compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005035 acylthio group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7829357 | 1978-07-10 | ||
| GB7850334 | 1978-12-29 | ||
| AU23283/84A AU2328384A (en) | 1978-12-29 | 1984-01-13 | 1,2,4-thiadiazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES482323A1 true ES482323A1 (es) | 1980-08-16 |
Family
ID=32965858
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES482323A Expired ES482323A1 (es) | 1978-07-10 | 1979-07-09 | Un procedimiento para preparar nuevos compuestos de cefem. |
| ES490503A Granted ES490503A0 (es) | 1978-07-10 | 1980-04-11 | Un procedimiento para preparar nuevos compuestos de cefem |
| ES490504A Granted ES490504A0 (es) | 1978-07-10 | 1980-04-11 | Procedimiento para preparar nuevos compuestos de tiadiazoli-lo |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES490503A Granted ES490503A0 (es) | 1978-07-10 | 1980-04-11 | Un procedimiento para preparar nuevos compuestos de cefem |
| ES490504A Granted ES490504A0 (es) | 1978-07-10 | 1980-04-11 | Procedimiento para preparar nuevos compuestos de tiadiazoli-lo |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US4268509A (en, 2012) |
| EP (2) | EP0036673B1 (en, 2012) |
| JP (1) | JPS63264471A (en, 2012) |
| AR (1) | AR226539A1 (en, 2012) |
| AU (1) | AU533708B2 (en, 2012) |
| DE (1) | DE2966293D1 (en, 2012) |
| DK (1) | DK289079A (en, 2012) |
| ES (3) | ES482323A1 (en, 2012) |
| HU (1) | HU183010B (en, 2012) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1592149A (en) * | 1976-10-08 | 1981-07-01 | Fujisawa Pharmaceutical Co | 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof |
| FR2387235A1 (fr) * | 1978-01-23 | 1978-11-10 | Fujisawa Pharmaceutical Co | Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne |
| AU536842B2 (en) * | 1978-12-29 | 1984-05-24 | Fujisawa Pharmaceutical Co., Ltd. | Cephalosporin antibiotics |
| US4567275A (en) * | 1978-12-29 | 1986-01-28 | Fujisawa Pharmaceutical Co., Ltd. | Cephem and cepham compounds and processes for preparation thereof |
| US4390534A (en) * | 1978-12-29 | 1983-06-28 | Fujisawa Pharmaceutical Co., Ltd. | Cephem and cepham compounds |
| US4332798A (en) * | 1978-12-29 | 1982-06-01 | Fujisawa Pharmaceutical Co., Ltd. | 7-Amino-thia-diazole oxyimino derivatives of cephem and cephem compounds |
| US4331666A (en) * | 1979-05-11 | 1982-05-25 | Farmitalia Carlo Erba S.P.A. | 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid |
| MA18891A1 (fr) * | 1979-07-05 | 1981-04-01 | Ciba Geigy Ag | Composes d'amino-thiadiazolyle,procede pour leur preparation |
| EP0025017A1 (de) * | 1979-08-28 | 1981-03-11 | Ciba-Geigy Ag | Polyazathiaverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend solche Verbindungen und Verwendung von letzteren |
| US4381299A (en) * | 1980-03-07 | 1983-04-26 | Fujisawa Pharmaceutical Co., Ltd. | 7-Amino-thiadiazole oxyimino derivatives of cephem and cepham compounds |
| US4405617A (en) * | 1980-02-11 | 1983-09-20 | Fujisawa Pharmaceutical Co., Ltd. | 3-(Propynyltetrazol)thiomethyl-3-cephems |
| GR78245B (en, 2012) * | 1980-09-12 | 1984-09-26 | Ciba Geigy Ag | |
| US4431642A (en) * | 1980-12-01 | 1984-02-14 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| US4521413A (en) * | 1981-09-14 | 1985-06-04 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| US4563449A (en) * | 1982-07-19 | 1986-01-07 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| CA1293719C (en) * | 1986-09-22 | 1991-12-31 | Takao Takaya | Cephem compounds and processes for preparation thereof |
| FR2729948A1 (fr) * | 1995-01-31 | 1996-08-02 | Oreal | Nouveaux derives d'arginine, procede de preparation, utilisations et compositions les comprenant |
| TW473479B (en) * | 1997-12-19 | 2002-01-21 | Takeda Chemical Industries Ltd | Phosphonocephem derivatives, their production and use |
| US8673894B2 (en) | 2010-05-07 | 2014-03-18 | Hoffmann-La Roche Inc. | 2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine or 2,3,6,7-tetrahydro-[1,4]oxazepin-5-ylamine compounds |
| SI3616695T1 (sl) | 2011-09-09 | 2025-01-31 | Merck Sharp & Dohme Llc | Ceftolozan/tazobaktam za zdravljenje intrapulmonalnih okužb |
| US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| UY35103A (es) | 2012-10-29 | 2014-05-30 | Glaxo Group Ltd | Compuestos de cefem 2-sustituidos |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| US20140274997A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Cephalosporin pharmaceutical compositions |
| MX387913B (es) | 2013-03-15 | 2025-03-19 | Merck Sharp & Dohme Llc | Composiciones antibioticas de ceftolozano |
| EP3043797B1 (en) | 2013-09-09 | 2020-04-08 | Merck Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093803A (en) * | 1971-05-14 | 1978-06-06 | Glaxo Laboratories Limited | 7β-[2-Etherified oximino-2-(thienyl-, furyl- or pyridylacetamido)] cephalosporins |
| GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
| BE791214A (fr) * | 1972-05-08 | 1973-05-10 | Glaxo Lab Ltd | Procede de preparation d'isomeres de derives d'acide hydroxyiminoacetique etherifie purs |
| DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
| US4166115A (en) * | 1976-04-12 | 1979-08-28 | Fujisawa Pharmaceutical Co., Ltd. | Syn 7-oxoimino substituted derivatives of cephalosporanic acid |
| GB1592149A (en) | 1976-10-08 | 1981-07-01 | Fujisawa Pharmaceutical Co | 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof |
| PH17188A (en) * | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
| US4468515A (en) * | 1978-12-29 | 1984-08-28 | Fujisawa Pharmaceutical Co., Ltd. | 2-Substituted oxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl)acetic acids |
-
1979
- 1979-06-20 US US06/050,216 patent/US4268509A/en not_active Expired - Lifetime
- 1979-07-02 DE DE7979102224T patent/DE2966293D1/de not_active Expired
- 1979-07-02 EP EP81102352A patent/EP0036673B1/en not_active Expired
- 1979-07-02 EP EP79102224A patent/EP0007470B1/en not_active Expired
- 1979-07-05 AU AU48695/79A patent/AU533708B2/en not_active Ceased
- 1979-07-09 DK DK289079A patent/DK289079A/da not_active Application Discontinuation
- 1979-07-09 HU HU79FU370A patent/HU183010B/hu unknown
- 1979-07-09 ES ES482323A patent/ES482323A1/es not_active Expired
- 1979-07-10 AR AR277246A patent/AR226539A1/es active
-
1980
- 1980-04-11 ES ES490503A patent/ES490503A0/es active Granted
- 1980-04-11 ES ES490504A patent/ES490504A0/es active Granted
- 1980-12-05 US US06/213,351 patent/US4447429A/en not_active Expired - Lifetime
-
1984
- 1984-01-16 US US06/571,380 patent/US4585872A/en not_active Expired - Lifetime
-
1988
- 1988-04-08 JP JP63087862A patent/JPS63264471A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0007470B1 (en) | 1983-10-12 |
| EP0036673A1 (en) | 1981-09-30 |
| ES8103072A1 (es) | 1981-02-16 |
| US4585872A (en) | 1986-04-29 |
| EP0007470A2 (en) | 1980-02-06 |
| AU533708B2 (en) | 1983-12-08 |
| JPS63264471A (ja) | 1988-11-01 |
| JPH0368028B2 (en, 2012) | 1991-10-25 |
| ES8103102A1 (es) | 1981-02-16 |
| ES490504A0 (es) | 1981-02-16 |
| DK289079A (da) | 1980-01-11 |
| US4447429A (en) | 1984-05-08 |
| US4268509A (en) | 1981-05-19 |
| AR226539A1 (es) | 1982-07-30 |
| AU4869579A (en) | 1980-02-07 |
| ES490503A0 (es) | 1981-02-16 |
| EP0007470A3 (en) | 1980-04-16 |
| EP0036673B1 (en) | 1984-07-11 |
| HU183010B (en) | 1984-04-28 |
| DE2966293D1 (en) | 1983-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8103102A1 (es) | Un procedimiento para preparar nuevos compuestos de cefem | |
| ES8107207A1 (es) | Procedimiento de preparacion de derivados de tiadiazol | |
| ES8300112A1 (es) | Un procedimiento para preparar compuestos de cefem . | |
| ES8306160A1 (es) | "procedimiento para preparar un nuevo compuesto de cefem". | |
| TW369535B (en) | A pyrazolopyridine compound and the process for preparing thereof | |
| IE820211L (en) | Process for preparing 2-penem compounds | |
| ES8608526A1 (es) | Un procedimiento para preparar nuevos compuestos de cefem | |
| ES8506730A1 (es) | Un procedimiento para preparar nuevos compuestos de cefem. | |
| DE3176274D1 (en) | New cephem compounds and processes for preparation thereof | |
| ES8300774A1 (es) | Un procedimiento para preparar nuevos compuestos de cefem | |
| DE3363550D1 (en) | New nitro aliphatic compounds, process for preparation thereof and use thereof | |
| DE2964903D1 (en) | 2-lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compounds, processes for their preparation and pharmaceutical compositions containing them | |
| ES8405005A1 (es) | Un procedimiento para la preparacion de derivados del acido tetrahidrofurancarboxilico. | |
| ES8404360A1 (es) | Un procedimiento para preparar compuestos de cefem. | |
| ES8308569A1 (es) | "un procedimiento para preparar compuestos de cefem". | |
| DE2964634D1 (en) | 3,7-disubstituted-2- or -3-cephem-4-carboxylic acid compounds, pharmaceutical compositions containing them and processes for the preparation thereof | |
| ES8405409A1 (es) | Un procedimiento para la preparacion de derivados de b-lactama. | |
| ES8304923A1 (es) | Un procedimiento para la preparacion de un peptido. | |
| ES8302719A1 (es) | Un procedimiento para preparar compuestos de cefem | |
| ES8105734A1 (es) | Un procedimiento para la preparacion de agentes antibacterianos beta-lactanicos. | |
| DE2965943D1 (en) | Cepham compounds, pharmaceutical compositions containing them and processes for the preparation thereof and of known cephem compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20001204 |