ES479738A1 - Procedure for preparing pyrimidones. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparing pyrimidones. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES479738A1
ES479738A1 ES479738A ES479738A ES479738A1 ES 479738 A1 ES479738 A1 ES 479738A1 ES 479738 A ES479738 A ES 479738A ES 479738 A ES479738 A ES 479738A ES 479738 A1 ES479738 A1 ES 479738A1
Authority
ES
Spain
Prior art keywords
group
formula
optionally substituted
lower alkyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479738A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Original Assignee
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd, GlaxoSmithKline LLC filed Critical Smith Kline and French Laboratories Ltd
Priority to ES479738A priority Critical patent/ES479738A1/en
Publication of ES479738A1 publication Critical patent/ES479738A1/en
Expired legal-status Critical Current

Links

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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Process for preparing pyrimidones, of formula (1) ** (Formula-01) ** wherein Het is a 2- or 4-imidazolyl group optionally substituted by lower alkyl, halogen, trifluoromethyl or hydroxymethyl; a 2-pyridyl group optionally substituted by one or more lower alkyl, lower alkoxy, halogen, amino or hydroxy groups; a 2-thiazolite group; a 3-isothiazolyl group optionally substituted by chlorine or bromine; or a 2- (5-amino-1,3,4-thiadiazolyl) group; Y is sulfur or methylene; Z is hydrogen or lower alkyl; A is C1-C5 alkylene and Het1 is a pyridyl group substituted by hydroxy or N-oxo and optionally substituted by lower alkyl or lower alkoxy; characterized in that a compound of formula (3) ** (Formula-02) ** is reacted where Q is nitroamine, lower alkylithium, benzylthio, chlorine, bromine or another group that can be displaced with a primary amine, Z and A are defined as in formula (1), and Het2 is a pyridyl group substituted by hydroxy or a protected hydroxy group or N-oxo and optionally substituted by lower alkyl or lower alkoxy, with an amine of formula (2) and separating any group hydroxy-protector. (Machine-translation by Google Translate, not legally binding)
ES479738A 1979-04-19 1979-04-19 Procedure for preparing pyrimidones. (Machine-translation by Google Translate, not legally binding) Expired ES479738A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES479738A ES479738A1 (en) 1979-04-19 1979-04-19 Procedure for preparing pyrimidones. (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES479738A ES479738A1 (en) 1979-04-19 1979-04-19 Procedure for preparing pyrimidones. (Machine-translation by Google Translate, not legally binding)

Publications (1)

Publication Number Publication Date
ES479738A1 true ES479738A1 (en) 1979-12-01

Family

ID=8478096

Family Applications (1)

Application Number Title Priority Date Filing Date
ES479738A Expired ES479738A1 (en) 1979-04-19 1979-04-19 Procedure for preparing pyrimidones. (Machine-translation by Google Translate, not legally binding)

Country Status (1)

Country Link
ES (1) ES479738A1 (en)

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