DK253583A - PROCEDURE FOR PREPARING BENZHYDRYLSULPHINYLACETAMIDE DERIVATIVES - Google Patents
PROCEDURE FOR PREPARING BENZHYDRYLSULPHINYLACETAMIDE DERIVATIVES Download PDFInfo
- Publication number
- DK253583A DK253583A DK253583A DK253583A DK253583A DK 253583 A DK253583 A DK 253583A DK 253583 A DK253583 A DK 253583A DK 253583 A DK253583 A DK 253583A DK 253583 A DK253583 A DK 253583A
- Authority
- DK
- Denmark
- Prior art keywords
- represent
- general formula
- derivative
- different
- see diagramm
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
- C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/18—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part
- C07C33/24—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part polycyclic without condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A novel benzhydrylsulfinylacetamide derivative characterized in that it is selected from the group consisting of compounds of the general formula : see diagramm : EP0097071,P21,F1 wherein - X1 and X2 , which may be identical or different each represent H, Cl or F, - Z1 represents CH3 , CH2 CH3 , CH(CH3 )2 or C(CH3 )3 , Z1 may represent the hydrogen atom when at least one of X1 and X2 is different from H, - Z2 represents H ; NZ1 Z2 considered together may represent a piperidino or morpholino group. For the contracting state AT 1. A method for the preparation of a novel benzhydrylsulfinylacetamide derivative of the general formula : see diagramm : EP0097071,P22,F1 wherein : - X1 and X2 which may be identical or different each represent H, Cl or F, - Z1 represents CH3 , CH2 CH3 , CH(CH3 )2 or C(CH3 )3 , Z1 may represent the hydrogen atom when at least one of X1 and X2 is different from H, - Z2 represents H ; NZ1 Z2 considered together may represent a piperidino or morpholino group, characterized in that an acid chloride of general formula see diagramm : EP0097071,P22,F2 wherein X1 and X2 are as defined above, is reacted with an amine of general formula HNZ1 Z2 wherein Z1 and Z2 have the above definition, to a benzhydrythiocetamide derivative of general formula see diagramm : EP0097071,P22,F3 wherein X1 , X2 , Z1 and Z2 are as defined above, and the obtained benzhydrylthiocetamide derivative of formula (IV) is oxidized.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8209802A FR2528038B2 (en) | 1982-06-04 | 1982-06-04 | BENZHYDRYLSULFINYLACETAMIDE DERIVATIVES AND THEIR THERAPEUTIC USE |
FR8209802 | 1982-06-04 |
Publications (4)
Publication Number | Publication Date |
---|---|
DK253583D0 DK253583D0 (en) | 1983-06-03 |
DK253583A true DK253583A (en) | 1983-12-05 |
DK158039B DK158039B (en) | 1990-03-19 |
DK158039C DK158039C (en) | 1990-08-13 |
Family
ID=9274663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK253583A DK158039C (en) | 1982-06-04 | 1983-06-03 | ANALOGY PROCEDURE FOR PREPARING BENZHYDRYLSULPHINYLACETAMIDE DERIVATIVES |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0097071B1 (en) |
JP (1) | JPS591459A (en) |
AT (1) | ATE15185T1 (en) |
CA (1) | CA1199916A (en) |
DE (1) | DE3360668D1 (en) |
DK (1) | DK158039C (en) |
ES (1) | ES8403445A1 (en) |
FR (1) | FR2528038B2 (en) |
IE (1) | IE54988B1 (en) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6196949A (en) * | 1984-10-18 | 1986-05-15 | Nisshin Oil Mills Ltd:The | Production of food like snack |
FR2584666B1 (en) * | 1985-07-10 | 1989-06-16 | Champion Spark Plug Europ | MOTOR ARM FOR WIPER BLADE WITH SLIDING CAP |
FR2593809B1 (en) * | 1986-01-31 | 1988-07-22 | Lafon Labor | BENZHYDRYLSULFINYLACETAMIDE, PROCESS FOR PREPARATION AND THERAPEUTIC USE |
GB8610911D0 (en) * | 1986-05-03 | 1986-06-11 | Beecham Group Plc | Active compounds |
FR2602768B1 (en) * | 1986-08-13 | 1989-02-03 | Lafon Labor | 2- (4,4'-DIFLUORO BENZHYDRYL THIO) ACETIC ACID DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC APPLICATIONS |
FR2606015B1 (en) * | 1986-08-13 | 1989-05-19 | Lafon Labor | BENZHYDRYLTHIOMETHANE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC APPLICATIONS |
IT1238489B (en) * | 1990-02-08 | 1993-08-18 | Mario Nobile Caprile | BATTERY CHARGING DEVICE |
FR2708201B1 (en) * | 1993-06-30 | 1995-10-20 | Lafon Labor | Use of acetamide derivatives for the manufacture of medicaments. |
FR2707637B1 (en) * | 1993-06-30 | 1995-10-06 | Lafon Labor | New acetamide derivatives, their preparation process and their use in therapy. |
US6492396B2 (en) * | 2000-05-16 | 2002-12-10 | Cephalon, Inc. | Substituted thioacetamides |
IL143106A (en) * | 2001-05-13 | 2005-11-20 | Chemagis Ltd | Process for the preparation of diphenylmethylthioacetamide |
US20040048931A1 (en) | 2002-07-12 | 2004-03-11 | Craig Heacock | Modafinil pharmaceutical compositions |
EP1437345A1 (en) * | 2003-01-13 | 2004-07-14 | Organisation de Synthese Mondiale Orsymonde | Novel method for preparing methyl 2-diphenylmethylsulfinylacetate |
JP2006518754A (en) | 2003-02-24 | 2006-08-17 | マリンクロッド・インコーポレイテッド | Improved process for the preparation of benzhydrylthioacetamide. |
US7368591B2 (en) | 2003-09-19 | 2008-05-06 | Cephalon France | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation |
EP1516869A1 (en) * | 2003-09-19 | 2005-03-23 | Cephalon France | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation |
US7314875B2 (en) | 2004-04-13 | 2008-01-01 | Cephalon, Inc. | Tricyclic aromatic and bis-phenyl sulfinyl derivatives |
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Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1584462A (en) * | 1977-03-31 | 1981-02-11 | Lafon Labor | N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them |
-
1982
- 1982-06-04 FR FR8209802A patent/FR2528038B2/en not_active Expired
-
1983
- 1983-05-26 DE DE8383401046T patent/DE3360668D1/en not_active Expired
- 1983-05-26 AT AT83401046T patent/ATE15185T1/en not_active IP Right Cessation
- 1983-05-26 EP EP83401046A patent/EP0097071B1/en not_active Expired
- 1983-05-30 IE IE1277/83A patent/IE54988B1/en not_active IP Right Cessation
- 1983-05-31 CA CA000429261A patent/CA1199916A/en not_active Expired
- 1983-06-03 ES ES522981A patent/ES8403445A1/en not_active Expired
- 1983-06-03 DK DK253583A patent/DK158039C/en not_active IP Right Cessation
- 1983-06-04 JP JP58098798A patent/JPS591459A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
IE54988B1 (en) | 1990-04-11 |
ATE15185T1 (en) | 1985-09-15 |
CA1199916A (en) | 1986-01-28 |
DE3360668D1 (en) | 1985-10-03 |
DK158039C (en) | 1990-08-13 |
JPS591459A (en) | 1984-01-06 |
FR2528038B2 (en) | 1985-08-09 |
EP0097071B1 (en) | 1985-08-28 |
ES522981A0 (en) | 1984-03-16 |
DK253583D0 (en) | 1983-06-03 |
IE831277L (en) | 1983-12-04 |
FR2528038A2 (en) | 1983-12-09 |
EP0097071A1 (en) | 1983-12-28 |
DK158039B (en) | 1990-03-19 |
ES8403445A1 (en) | 1984-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired |