DK253583D0 - PROCEDURE FOR PREPARING BENZHYDRYLSULPHINYLACETAMIDE DERIVATIVES - Google Patents

PROCEDURE FOR PREPARING BENZHYDRYLSULPHINYLACETAMIDE DERIVATIVES

Info

Publication number
DK253583D0
DK253583D0 DK2535/83A DK253583A DK253583D0 DK 253583 D0 DK253583 D0 DK 253583D0 DK 2535/83 A DK2535/83 A DK 2535/83A DK 253583 A DK253583 A DK 253583A DK 253583 D0 DK253583 D0 DK 253583D0
Authority
DK
Denmark
Prior art keywords
represent
general formula
derivative
different
see diagramm
Prior art date
Application number
DK2535/83A
Other languages
Danish (da)
Other versions
DK158039B (en
DK253583A (en
DK158039C (en
Inventor
Louis Lafon
Original Assignee
Lafon Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lafon Labor filed Critical Lafon Labor
Publication of DK253583D0 publication Critical patent/DK253583D0/en
Publication of DK253583A publication Critical patent/DK253583A/en
Publication of DK158039B publication Critical patent/DK158039B/en
Application granted granted Critical
Publication of DK158039C publication Critical patent/DK158039C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/18—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part
    • C07C33/24—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part polycyclic without condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A novel benzhydrylsulfinylacetamide derivative characterized in that it is selected from the group consisting of compounds of the general formula : see diagramm : EP0097071,P21,F1 wherein - X1 and X2 , which may be identical or different each represent H, Cl or F, - Z1 represents CH3 , CH2 CH3 , CH(CH3 )2 or C(CH3 )3 , Z1 may represent the hydrogen atom when at least one of X1 and X2 is different from H, - Z2 represents H ; NZ1 Z2 considered together may represent a piperidino or morpholino group. For the contracting state AT 1. A method for the preparation of a novel benzhydrylsulfinylacetamide derivative of the general formula : see diagramm : EP0097071,P22,F1 wherein : - X1 and X2 which may be identical or different each represent H, Cl or F, - Z1 represents CH3 , CH2 CH3 , CH(CH3 )2 or C(CH3 )3 , Z1 may represent the hydrogen atom when at least one of X1 and X2 is different from H, - Z2 represents H ; NZ1 Z2 considered together may represent a piperidino or morpholino group, characterized in that an acid chloride of general formula see diagramm : EP0097071,P22,F2 wherein X1 and X2 are as defined above, is reacted with an amine of general formula HNZ1 Z2 wherein Z1 and Z2 have the above definition, to a benzhydrythiocetamide derivative of general formula see diagramm : EP0097071,P22,F3 wherein X1 , X2 , Z1 and Z2 are as defined above, and the obtained benzhydrylthiocetamide derivative of formula (IV) is oxidized.
DK253583A 1982-06-04 1983-06-03 ANALOGY PROCEDURE FOR PREPARING BENZHYDRYLSULPHINYLACETAMIDE DERIVATIVES DK158039C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8209802 1982-06-04
FR8209802A FR2528038B2 (en) 1982-06-04 1982-06-04 BENZHYDRYLSULFINYLACETAMIDE DERIVATIVES AND THEIR THERAPEUTIC USE

Publications (4)

Publication Number Publication Date
DK253583D0 true DK253583D0 (en) 1983-06-03
DK253583A DK253583A (en) 1983-12-05
DK158039B DK158039B (en) 1990-03-19
DK158039C DK158039C (en) 1990-08-13

Family

ID=9274663

Family Applications (1)

Application Number Title Priority Date Filing Date
DK253583A DK158039C (en) 1982-06-04 1983-06-03 ANALOGY PROCEDURE FOR PREPARING BENZHYDRYLSULPHINYLACETAMIDE DERIVATIVES

Country Status (9)

Country Link
EP (1) EP0097071B1 (en)
JP (1) JPS591459A (en)
AT (1) ATE15185T1 (en)
CA (1) CA1199916A (en)
DE (1) DE3360668D1 (en)
DK (1) DK158039C (en)
ES (1) ES522981A0 (en)
FR (1) FR2528038B2 (en)
IE (1) IE54988B1 (en)

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JPS6196949A (en) * 1984-10-18 1986-05-15 Nisshin Oil Mills Ltd:The Production of food like snack
FR2584666B1 (en) * 1985-07-10 1989-06-16 Champion Spark Plug Europ MOTOR ARM FOR WIPER BLADE WITH SLIDING CAP
FR2593809B1 (en) * 1986-01-31 1988-07-22 Lafon Labor BENZHYDRYLSULFINYLACETAMIDE, PROCESS FOR PREPARATION AND THERAPEUTIC USE
GB8610911D0 (en) * 1986-05-03 1986-06-11 Beecham Group Plc Active compounds
FR2606015B1 (en) * 1986-08-13 1989-05-19 Lafon Labor BENZHYDRYLTHIOMETHANE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC APPLICATIONS
FR2602768B1 (en) * 1986-08-13 1989-02-03 Lafon Labor 2- (4,4'-DIFLUORO BENZHYDRYL THIO) ACETIC ACID DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC APPLICATIONS
IT1238489B (en) * 1990-02-08 1993-08-18 Mario Nobile Caprile BATTERY CHARGING DEVICE
FR2708201B1 (en) * 1993-06-30 1995-10-20 Lafon Labor Use of acetamide derivatives for the manufacture of medicaments.
FR2707637B1 (en) * 1993-06-30 1995-10-06 Lafon Labor New acetamide derivatives, their preparation process and their use in therapy.
US6492396B2 (en) * 2000-05-16 2002-12-10 Cephalon, Inc. Substituted thioacetamides
IL143106A (en) * 2001-05-13 2005-11-20 Chemagis Ltd Process for the preparation of diphenylmethylthioacetamide
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
EP1437345A1 (en) * 2003-01-13 2004-07-14 Organisation de Synthese Mondiale Orsymonde Novel method for preparing methyl 2-diphenylmethylsulfinylacetate
CN1753867A (en) 2003-02-24 2006-03-29 马林克罗特公司 Process for preparing benzhydrylthioacetamide
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1516869A1 (en) * 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US7314875B2 (en) 2004-04-13 2008-01-01 Cephalon, Inc. Tricyclic aromatic and bis-phenyl sulfinyl derivatives
FR2970711B1 (en) * 2011-01-20 2016-03-04 Hopitaux Paris Assist Publique LAUFLUMIDE AND ITS ENANTIOMERS, PREPARATION AND THERAPEUTIC USES
WO2014037832A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment of epilepsy and neurological diseases
US9399634B2 (en) 2012-05-07 2016-07-26 Cellix Bio Private Limited Compositions and methods for the treatment of depression
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US9321775B2 (en) 2012-05-10 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of moderate to severe pain
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WO2019094856A1 (en) 2017-11-13 2019-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Atypical inhibitors of monoamine transporters; method of making; and use thereof
KR102126389B1 (en) * 2018-09-14 2020-06-25 셀라이온바이오메드 주식회사 A composition for preventing or treating liver diseases comprising benzhydrylthio acetamide derivative as an active ingredient

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Also Published As

Publication number Publication date
EP0097071B1 (en) 1985-08-28
DK158039B (en) 1990-03-19
ES8403445A1 (en) 1984-03-16
ES522981A0 (en) 1984-03-16
JPS591459A (en) 1984-01-06
ATE15185T1 (en) 1985-09-15
EP0097071A1 (en) 1983-12-28
DK253583A (en) 1983-12-05
FR2528038B2 (en) 1985-08-09
CA1199916A (en) 1986-01-28
FR2528038A2 (en) 1983-12-09
IE54988B1 (en) 1990-04-11
DK158039C (en) 1990-08-13
IE831277L (en) 1983-12-04
DE3360668D1 (en) 1985-10-03

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