ES476473A1 - Procedimiento para la preparacion de acidos acilhidrocarbi- laminoalcanoicos - Google Patents
Procedimiento para la preparacion de acidos acilhidrocarbi- laminoalcanoicosInfo
- Publication number
- ES476473A1 ES476473A1 ES476473A ES476473A ES476473A1 ES 476473 A1 ES476473 A1 ES 476473A1 ES 476473 A ES476473 A ES 476473A ES 476473 A ES476473 A ES 476473A ES 476473 A1 ES476473 A1 ES 476473A1
- Authority
- ES
- Spain
- Prior art keywords
- optionally substituted
- substituted phenyl
- pharmaceutical compositions
- acylhydrocarbylaminoalcanecarboxylic
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group, wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dentistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Agronomy & Crop Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedimiento para la preparación de los ácidos acilhidrocarbilaminoalcanoicos de la fórmula general I **fórmula** , en donde R1 significa un radical hidrocarbonado alifático o alicíclico o un grupo fenilo eventualmente sustituído, R2 significa un átomo de hidrógeno, un grupo alcohilo, un grupo alquenilo o un grupo alquinilo, R3 significa un átomo de hidrógeno, un grupo alcohilo, un grupo cicloalcohilo o un radical fenilo eventualmente sustituído, R4 significa un grupo alcohilo, un grupo cicloalcohilo, un grupo fenilo eventualmente sustituído siendo al menos 3 la suma de de los átomos de carbono de los sustituyents alcohilo R2, R3 y R4, ó R3 y R4 significan en común un grupo alcohileno o R2, R3 y R4 con inclusión del átomo de carbono contiguo significan un radical adamantilo, n significa 3, 4 ó 5, así como sus sales con bases orgánicas o inorgánicas, caracterizado porque se acila un ácido hidrocarbilaminoalcanoico de la fórmula general II **fórmula** en donde R2, R3 R4 y n tienen los significados precedentemente indicados, eventualmente con protección del grupo carboxilo, con un derivado¿acílico de la fórmula general III R1-CO-R8 (III), en donde R8 significa un grupo sobrante activo o un grupo R1-CO-O y R1 tiene los significados arriba mencionados y eventualmente a continuación se transforma en las sales ; se hidrogena un ácido hidrocarbilaminoalquenoico de la fórmula general IV **fórmula**, en donde R1 R2, R3 ,R4 y n tienes los significados precedentemente indicados, eventualmente con protección del grupo carboxilo, y eventualmente a continuación se transforma en las sales; o se hace reaccionar un ácido acilaminoalcanoico de la fórmula general V **fórmula**, en donde R1 y n tienen los significados arriba indicados y R9 significa un átomo de hidrógeno o un átomo metálico de un metal alcalino o alcalino-térreo, eventualmente con protección del grupo carboxilo, con un derivado hidrocarbílico de la fórmula general VI **fórmula** en donde R2 , R3 y R4 tienen los significados arriba indicados y R10 representa un grupo sobrante activo, y eventualmente a continuación se transforma en las sales; o se solvoliza un derivado funcional de ácido acilhidrocarbilaminoalcanoico de la fórmula general VII **fórmula** en donde R1, R2, R3 R4 y n tienen los significados arriba indicados y A significa un derivado funcional de un grupo carboxilo, y eventualmente a continuación se transforma en las sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU78805A LU78805A1 (de) | 1977-12-30 | 1977-12-30 | Acylhydrocarbylaminoalkansaeuren,ihre herstellung und verwendung sowie sie enthaltende arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES476473A1 true ES476473A1 (es) | 1979-11-16 |
Family
ID=19728815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES476473A Expired ES476473A1 (es) | 1977-12-30 | 1978-12-29 | Procedimiento para la preparacion de acidos acilhidrocarbi- laminoalcanoicos |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0002836B1 (es) |
| JP (1) | JPS5498720A (es) |
| AT (1) | AT367396B (es) |
| AU (1) | AU526987B2 (es) |
| BE (1) | BE873259A (es) |
| CA (1) | CA1123433A (es) |
| DE (2) | DE2862077D1 (es) |
| DK (1) | DK588378A (es) |
| ES (1) | ES476473A1 (es) |
| FR (1) | FR2413360A1 (es) |
| GB (1) | GB2012274A (es) |
| GR (1) | GR64162B (es) |
| HU (1) | HU181857B (es) |
| IL (1) | IL56344A0 (es) |
| IT (1) | IT7831447A0 (es) |
| LU (1) | LU78805A1 (es) |
| NL (1) | NL7812644A (es) |
| NZ (1) | NZ189295A (es) |
| PL (4) | PL218178A1 (es) |
| PT (1) | PT69009A (es) |
| SE (1) | SE7813442L (es) |
| ZA (1) | ZA787367B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440941A (en) * | 1980-12-22 | 1984-04-03 | Usv Pharmaceutical Corporation | Aroyl-aminoacids, amides and esters thereof |
| DK373383A (da) * | 1982-08-20 | 1984-02-21 | Midit | Fremgangsmaade til fremstilling af omega-aminosyrederivater |
| JPS62205095A (ja) * | 1986-03-04 | 1987-09-09 | Toyo Jozo Co Ltd | 新生理活性物質アルドスタチンおよびその製造法 |
| US6420427B1 (en) * | 1997-10-09 | 2002-07-16 | Ono Pharmaceutical Co., Ltd. | Aminobutyric acid derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1645745A1 (de) * | 1967-02-22 | 1970-12-23 | Hoechst Ag | Korrosionsschutzmittel fuer fluessige Kohlenwasserstoffe |
| LU69970A1 (es) * | 1974-04-30 | 1976-03-17 |
-
1977
- 1977-12-30 LU LU78805A patent/LU78805A1/de unknown
-
1978
- 1978-12-21 CA CA318,459A patent/CA1123433A/en not_active Expired
- 1978-12-28 JP JP16128678A patent/JPS5498720A/ja active Pending
- 1978-12-28 ZA ZA00787367A patent/ZA787367B/xx unknown
- 1978-12-29 IL IL56344A patent/IL56344A0/xx unknown
- 1978-12-29 ES ES476473A patent/ES476473A1/es not_active Expired
- 1978-12-29 GR GR58004A patent/GR64162B/el unknown
- 1978-12-29 AT AT0938178A patent/AT367396B/de not_active IP Right Cessation
- 1978-12-29 IT IT7831447A patent/IT7831447A0/it unknown
- 1978-12-29 DE DE7878101869T patent/DE2862077D1/de not_active Expired
- 1978-12-29 PL PL21817878A patent/PL218178A1/xx unknown
- 1978-12-29 BE BE6046722A patent/BE873259A/xx unknown
- 1978-12-29 SE SE7813442A patent/SE7813442L/xx unknown
- 1978-12-29 AU AU43010/78A patent/AU526987B2/en not_active Expired
- 1978-12-29 GB GB7850239A patent/GB2012274A/en not_active Withdrawn
- 1978-12-29 NL NL7812644A patent/NL7812644A/xx not_active Application Discontinuation
- 1978-12-29 EP EP78101869A patent/EP0002836B1/de not_active Expired
- 1978-12-29 PL PL21817778A patent/PL218177A1/xx unknown
- 1978-12-29 PT PT69009A patent/PT69009A/pt unknown
- 1978-12-29 DK DK588378A patent/DK588378A/da not_active Application Discontinuation
- 1978-12-29 FR FR7836851A patent/FR2413360A1/fr not_active Withdrawn
- 1978-12-29 PL PL21229678A patent/PL212296A1/xx unknown
- 1978-12-29 HU HU78BI581A patent/HU181857B/hu unknown
- 1978-12-29 DE DE19782856722 patent/DE2856722A1/de not_active Withdrawn
- 1978-12-29 PL PL21817678A patent/PL218176A1/xx unknown
-
1979
- 1979-01-04 NZ NZ189295A patent/NZ189295A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LU78805A1 (de) | 1979-07-20 |
| DK588378A (da) | 1979-07-01 |
| DE2862077D1 (en) | 1982-12-02 |
| DE2856722A1 (de) | 1979-07-12 |
| PL212296A1 (es) | 1980-01-14 |
| IL56344A0 (en) | 1979-03-12 |
| PL218178A1 (es) | 1980-05-19 |
| PT69009A (de) | 1979-01-01 |
| AU4301078A (en) | 1979-07-05 |
| CA1123433A (en) | 1982-05-11 |
| GB2012274A (en) | 1979-07-25 |
| GR64162B (en) | 1980-02-05 |
| EP0002836A1 (de) | 1979-07-11 |
| ATA938178A (de) | 1981-11-15 |
| AT367396B (de) | 1982-06-25 |
| PL218177A1 (es) | 1980-05-19 |
| HU181857B (en) | 1983-11-28 |
| SE7813442L (sv) | 1979-07-01 |
| NL7812644A (nl) | 1979-07-03 |
| NZ189295A (en) | 1980-11-14 |
| FR2413360A1 (fr) | 1979-07-27 |
| PL218176A1 (es) | 1980-05-19 |
| EP0002836B1 (de) | 1982-10-27 |
| ZA787367B (en) | 1979-12-27 |
| AU526987B2 (en) | 1983-02-10 |
| BE873259A (fr) | 1979-06-29 |
| IT7831447A0 (it) | 1978-12-29 |
| JPS5498720A (en) | 1979-08-03 |
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