ES472993A1 - Procedimiento para la obtencion de derivados de ergolina - Google Patents
Procedimiento para la obtencion de derivados de ergolinaInfo
- Publication number
- ES472993A1 ES472993A1 ES472993A ES472993A ES472993A1 ES 472993 A1 ES472993 A1 ES 472993A1 ES 472993 A ES472993 A ES 472993A ES 472993 A ES472993 A ES 472993A ES 472993 A1 ES472993 A1 ES 472993A1
- Authority
- ES
- Spain
- Prior art keywords
- ergoline
- therapy
- derivatives
- preparation
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Wrappers (AREA)
- Laminated Bodies (AREA)
Abstract
Procedimiento para la obtención de derivados de ergolina . El procedimiento antes mencionado se lleva a cabo convenientemente en forma análoga a reacciones conocidas. Para las condiciones reductoras se emplea preferentemente la hidrogenación catalítica en presencia de un catalizador de metal noble, por ejemplo paladio sobre carbón activo. Es preferente que se encuentre presente el ácido acético como disolvente y que se efectúe la reacción bajo condiciones atmosféricas normales. Con el fin de separar los componentes de la mezcla de isómeros resultante, pueden usarse métodos conocidos para separaciones análogas , por ejemplo la cromatografía. Empleando una mezcla de disolventes apropiada, por ejemplo CH2Cl2/CH3OH
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1073277 | 1977-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES472993A1 true ES472993A1 (es) | 1979-11-16 |
Family
ID=4366242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES472993A Expired ES472993A1 (es) | 1977-09-02 | 1978-08-31 | Procedimiento para la obtencion de derivados de ergolina |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4219556A (es) |
| EP (1) | EP0001062B1 (es) |
| JP (2) | JPS5448880A (es) |
| AT (1) | AT368500B (es) |
| AU (1) | AU520880B2 (es) |
| CA (1) | CA1109864A (es) |
| DE (1) | DE2860653D1 (es) |
| DK (1) | DK374778A (es) |
| ES (1) | ES472993A1 (es) |
| FI (1) | FI63400C (es) |
| IL (1) | IL55466A (es) |
| IT (1) | IT1098421B (es) |
| NZ (1) | NZ188299A (es) |
| PH (1) | PH15739A (es) |
| PT (1) | PT68491A (es) |
| ZA (1) | ZA785003B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0021206B1 (de) * | 1979-06-13 | 1983-06-22 | Schering Aktiengesellschaft | Neue (Ergolin-yl)-N', N'-diäthylharnstoff-Derivate, ihre Herstellung und sie enthaltende Arzneimittel |
| US4526892A (en) * | 1981-03-03 | 1985-07-02 | Farmitalia Carlo Erba, S.P.A. | Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3185695A (en) * | 1965-05-25 | Dbwethyl-ergoline ii derivatives | ||
| US2997470A (en) * | 1956-03-05 | 1961-08-22 | Lilly Co Eli | Lysergic acid amides |
| US4004011A (en) * | 1974-04-16 | 1977-01-18 | Sandoz Ltd. | 3-Pyridylamine substituted ergolines |
| DK147775A (es) * | 1974-04-16 | 1975-10-17 | Sandoz Ag |
-
1978
- 1978-07-11 JP JP8451578A patent/JPS5448880A/ja active Pending
- 1978-08-18 EP EP78100701A patent/EP0001062B1/de not_active Expired
- 1978-08-18 DE DE7878100701T patent/DE2860653D1/de not_active Expired
- 1978-08-24 DK DK374778A patent/DK374778A/da not_active Application Discontinuation
- 1978-08-24 FI FI782589A patent/FI63400C/fi not_active IP Right Cessation
- 1978-08-31 CA CA310,469A patent/CA1109864A/en not_active Expired
- 1978-08-31 NZ NZ188299A patent/NZ188299A/xx unknown
- 1978-08-31 AU AU39450/78A patent/AU520880B2/en not_active Expired
- 1978-08-31 PT PT68491A patent/PT68491A/pt unknown
- 1978-08-31 ES ES472993A patent/ES472993A1/es not_active Expired
- 1978-08-31 IL IL55466A patent/IL55466A/xx unknown
- 1978-08-31 PH PH21553A patent/PH15739A/en unknown
- 1978-09-01 ZA ZA785003A patent/ZA785003B/xx unknown
- 1978-09-01 IT IT27256/78A patent/IT1098421B/it active
- 1978-09-01 AT AT0633678A patent/AT368500B/de not_active IP Right Cessation
- 1978-09-01 JP JP10803378A patent/JPS5448800A/ja active Pending
- 1978-09-01 US US05/939,105 patent/US4219556A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PH15739A (en) | 1983-03-18 |
| FI63400C (fi) | 1983-06-10 |
| ZA785003B (en) | 1980-04-30 |
| IT7827256A0 (it) | 1978-09-01 |
| EP0001062B1 (de) | 1981-04-29 |
| AU3945078A (en) | 1980-03-06 |
| DK374778A (da) | 1979-03-03 |
| PT68491A (fr) | 1978-09-01 |
| FI782589A (fi) | 1979-03-03 |
| IL55466A0 (en) | 1978-10-31 |
| JPS5448880A (en) | 1979-04-17 |
| EP0001062A1 (de) | 1979-03-21 |
| CA1109864A (en) | 1981-09-29 |
| ATA633678A (de) | 1982-02-15 |
| DE2860653D1 (en) | 1981-08-06 |
| NZ188299A (en) | 1981-03-16 |
| AU520880B2 (en) | 1982-03-04 |
| US4219556A (en) | 1980-08-26 |
| JPS5448800A (en) | 1979-04-17 |
| FI63400B (fi) | 1983-02-28 |
| IT1098421B (it) | 1985-09-07 |
| IL55466A (en) | 1981-09-13 |
| AT368500B (de) | 1982-10-11 |
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