ES471984A1 - process for their preparation. - Google Patents

process for their preparation.

Info

Publication number
ES471984A1
ES471984A1 ES471984A ES471984A ES471984A1 ES 471984 A1 ES471984 A1 ES 471984A1 ES 471984 A ES471984 A ES 471984A ES 471984 A ES471984 A ES 471984A ES 471984 A1 ES471984 A1 ES 471984A1
Authority
ES
Spain
Prior art keywords
see diagramm
diagramm
see
formula
pharmaceutically usable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES471984A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES471984A1 publication Critical patent/ES471984A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2201/00—Inorganic compounds or elements as ingredients in lubricant compositions
    • C10M2201/02—Water
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
    • C10M2209/10—Macromolecular compoundss obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C10M2209/103—Polyethers, i.e. containing di- or higher polyoxyalkylene groups
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
    • C10M2209/10—Macromolecular compoundss obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C10M2209/103—Polyethers, i.e. containing di- or higher polyoxyalkylene groups
    • C10M2209/104—Polyethers, i.e. containing di- or higher polyoxyalkylene groups of alkylene oxides containing two carbon atoms only
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2219/00—Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions
    • C10M2219/04—Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions containing sulfur-to-oxygen bonds, i.e. sulfones, sulfoxides
    • C10M2219/044—Sulfonic acids, Derivatives thereof, e.g. neutral salts
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
    • C10N2020/00—Specified physical or chemical properties or characteristics, i.e. function, of component of lubricating compositions
    • C10N2020/01—Physico-chemical properties
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
    • C10N2040/00—Specified use or application for which the lubricating composition is intended
    • C10N2040/20—Metal working

Abstract

1. An antibiotic composition, characterised in that it contains an active compound combination consisting of (1) beta-lactam antibiotics of the formula I : see diagramm : EP0000526,P9,F1 in which R1 represents see diagramm : EP0000526,P9,F2 see diagramm : EP0000526,P9,F3 see diagramm : EP0000526,P9,F4 see diagramm : EP0000526,P9,F5 see diagramm : EP0000526,P9,F6 and see diagramm : EP0000526,P9,F7 R2 represents phenyl, p-hydroxyphenyl or furyl, R3 represents H, OCH3 or OC2 H5 and wherein Y denotes see diagramm : EP0000526,P9,F8 or see diagramm : EP0000526,P9,F9 wherein T represents -O-CO-CH3 , -O-CO-NH2 , see diagramm : EP0000526,P9,F10 see diagramm : EP0000526,P9,F11 or see diagramm : EP0000526,P9,F12 and R4 is H, CH3 , -CH2 -COOH, -CH2 -SO3 H or -CH2 -CH2 -N(CH3 )2 or their pharmaceutically usable salts, in particular the sodium salts, or their various crystal or hydrate forms and (2) clavulanic acid of the formula II see diagramm : EP0000526,P9,F13 or its pharmaceutically usable salts or esters which can be split vivo, in particular its sodium salt.
ES471984A 1977-07-26 1978-07-24 process for their preparation. Expired ES471984A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772733642 DE2733642A1 (en) 1977-07-26 1977-07-26 ANTIBIOTIC AGENTS

Publications (1)

Publication Number Publication Date
ES471984A1 true ES471984A1 (en) 1979-10-16

Family

ID=6014859

Family Applications (1)

Application Number Title Priority Date Filing Date
ES471984A Expired ES471984A1 (en) 1977-07-26 1978-07-24 process for their preparation.

Country Status (8)

Country Link
EP (1) EP0000526B1 (en)
JP (1) JPS5435219A (en)
AT (1) AT361618B (en)
DE (2) DE2733642A1 (en)
DK (1) DK330478A (en)
ES (1) ES471984A1 (en)
IL (1) IL55206A (en)
IT (1) IT1097330B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2964817D1 (en) * 1978-09-06 1983-03-24 Beecham Group Plc Pharmaceutical compositions containing two beta-lactam derivatives
EP0049968A1 (en) * 1980-10-15 1982-04-21 Beecham Group Plc Pharmaceutical compositions
DE3039243A1 (en) * 1980-10-17 1982-05-27 Dr. Karl Thomae Gmbh, 7950 Biberach ANTIBIOTICALLY EFFECTIVE COMBINATION OF MEDICINAL PRODUCTS
JPS59104319A (en) * 1982-12-06 1984-06-16 Chugai Pharmaceut Co Ltd Antibacterial agent and its kit
JPS60146825A (en) * 1984-01-10 1985-08-02 Asahi Chem Ind Co Ltd Oral drug pharmaceutical
AT413015B (en) * 2001-04-12 2005-10-15 Sandoz Ag Pharmaceutical composition useful for reducing rapid degradation of the active ingredient comprises clavulanate, in the form of granulated and hydrophobised particles, and an active ingredient

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2648770A1 (en) * 1975-10-31 1977-05-05 Beecham Group Ltd (Alpha)-Heterocyclyl-carbonamido penicillins - derived from bicyclic heterocycles with a bridge head nitrogen atom

Also Published As

Publication number Publication date
IL55206A0 (en) 1978-09-29
AT361618B (en) 1981-03-25
DE2860275D1 (en) 1981-02-05
EP0000526B1 (en) 1980-11-12
IL55206A (en) 1981-12-31
JPS5435219A (en) 1979-03-15
EP0000526A1 (en) 1979-02-07
DE2733642A1 (en) 1979-02-08
IT7826041A0 (en) 1978-07-24
IT1097330B (en) 1985-08-31
DK330478A (en) 1979-03-02
ATA534478A (en) 1980-08-15

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