ES470772A1 - Novel manufacture of nn*11benzylpiperidoo44** benzamide - Google Patents

Novel manufacture of nn*11benzylpiperidoo44** benzamide

Info

Publication number
ES470772A1
ES470772A1 ES470772A ES470772A ES470772A1 ES 470772 A1 ES470772 A1 ES 470772A1 ES 470772 A ES470772 A ES 470772A ES 470772 A ES470772 A ES 470772A ES 470772 A1 ES470772 A1 ES 470772A1
Authority
ES
Spain
Prior art keywords
formula
prod
alkyl
degrees
benzamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES470772A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anphar SA
Original Assignee
Anphar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anphar SA filed Critical Anphar SA
Priority to ES470772A priority Critical patent/ES470772A1/en
Priority to NZ189085A priority patent/NZ189085A/en
Priority to IL56146A priority patent/IL56146A/en
Priority to FR7835285A priority patent/FR2428631A1/en
Priority to BE192227A priority patent/BE872641A/en
Priority to CA317,711A priority patent/CA1099719A/en
Priority to JP15297578A priority patent/JPS54163584A/en
Priority to AR274784A priority patent/AR224620A1/en
Publication of ES470772A1 publication Critical patent/ES470772A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Prepn. of piperdine derivs. of formula (I, R4isH) comprises firstly reacting a thiobenzoic acid deriv. of formula (II, Y is H) with ClCO2R5. Reactor is at -15 to 0 degrees C in an organic solvent in presence of NET3. The prod. of formula (I, Y is CO2R5) is reacted in situ a 0-20 degrees C with an amine of formula (III). The prod. of formula (I) is hydrolysed if R4 is other than H. In the formulae, X is Cl or Br.R1 is 1-6C alkyl. R2 and R3 are both H, or one is Cl in the 3- or 4- position or Me or OMe in the 4- position and the other is H, or R2 and R3 together form 3,4-OCH2O. R4 is H, CHO or 2-5C alkanoyl opt. substd. by 1-3 halo. R5 is 1-6C alkyl. (I, R4 is H) are antagonists of dopamine or depaminergic agents. The process gives ca. 95% yield. Inexpensive solvents can be used.
ES470772A 1978-06-14 1978-06-14 Novel manufacture of nn*11benzylpiperidoo44** benzamide Expired ES470772A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES470772A ES470772A1 (en) 1978-06-14 1978-06-14 Novel manufacture of nn*11benzylpiperidoo44** benzamide
NZ189085A NZ189085A (en) 1978-06-14 1978-12-04 Preparation ofn(1-benzylpiperid-4-yl)-benzamide derivatives
IL56146A IL56146A (en) 1978-06-14 1978-12-07 Process for the preparation of n-(1-benzylpiperid-4-yl)-benzamides
FR7835285A FR2428631A1 (en) 1978-06-14 1978-12-08 1-Benzyl-4-benzamido-piperidine deriv. prepn. - from thio-benzoic acid deriv., used as dopamine antagonist
BE192227A BE872641A (en) 1978-06-14 1978-12-08 PROCESS FOR THE PREPARATION OF N- (1-BENZYLPIPERID-4-YL) -BZENZAMIDES
CA317,711A CA1099719A (en) 1978-06-14 1978-12-11 Process for the preparation of n-(1-benzylpiperid-4- yl)-benzamides
JP15297578A JPS54163584A (en) 1978-06-14 1978-12-11 Novel manufacture of nn*11benzylpiperidoo44** benzamide
AR274784A AR224620A1 (en) 1978-06-14 1978-12-13 NEW PROCEDURE FOR THE PREPARATION OF N- (1-BENCILPIPERID-4-IL) -2 ALCOXI-4-AMINO-5-HALOBENZAMIDES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES470772A ES470772A1 (en) 1978-06-14 1978-06-14 Novel manufacture of nn*11benzylpiperidoo44** benzamide

Publications (1)

Publication Number Publication Date
ES470772A1 true ES470772A1 (en) 1979-01-16

Family

ID=8476283

Family Applications (1)

Application Number Title Priority Date Filing Date
ES470772A Expired ES470772A1 (en) 1978-06-14 1978-06-14 Novel manufacture of nn*11benzylpiperidoo44** benzamide

Country Status (8)

Country Link
JP (1) JPS54163584A (en)
AR (1) AR224620A1 (en)
BE (1) BE872641A (en)
CA (1) CA1099719A (en)
ES (1) ES470772A1 (en)
FR (1) FR2428631A1 (en)
IL (1) IL56146A (en)
NZ (1) NZ189085A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5822232U (en) * 1981-08-04 1983-02-10 相生精機株式会社 Clamp pallet exchange device for machine tools

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1507463A (en) * 1975-03-10 1978-04-12 Gallardo Antonio Sa N-(1-benzylpiperid-4-yl)-benzamides methods for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FR2428631A1 (en) 1980-01-11
JPS612063B2 (en) 1986-01-22
IL56146A (en) 1982-07-30
AR224620A1 (en) 1981-12-30
FR2428631B1 (en) 1982-12-31
NZ189085A (en) 1981-04-24
CA1099719A (en) 1981-04-21
JPS54163584A (en) 1979-12-26
BE872641A (en) 1979-06-08
IL56146A0 (en) 1979-03-12

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Legal Events

Date Code Title Description
GC1A Exploitation certificate registered application without search report

Effective date: 19970625