ES470679A1 - Procedimiento de preparacion de nuevos derivados del acido piperazinacarboditioico - Google Patents
Procedimiento de preparacion de nuevos derivados del acido piperazinacarboditioicoInfo
- Publication number
- ES470679A1 ES470679A1 ES470679A ES470679A ES470679A1 ES 470679 A1 ES470679 A1 ES 470679A1 ES 470679 A ES470679 A ES 470679A ES 470679 A ES470679 A ES 470679A ES 470679 A1 ES470679 A1 ES 470679A1
- Authority
- ES
- Spain
- Prior art keywords
- pyperadine
- carbodithionic
- production
- acid derivative
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 239000003513 alkali Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
Procedimiento de preparación de nuevos derivados del ácido piperazinacarboditioico, de fórmula general **(Fórmula-01)** en la cual: uno de los símbolos A y B representa un átomo de nitrógeno y el otro representa un átomo de oxígeno, de azufre o un radical > N - Y, en el cual Y es un átomo de hidrógeno o un radical metilo, o B es un átomo de azufre y A es un radical > C - R'', en el cual R'' es un átomo de hidrógeno, un radical alquilo teniendo de 1 a 5 átomos de carbono, un radical fenilo o un radical bencilo, R es un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo teniendo de 1 a 5 átomos de carbono o un radical fenilo, o cuando B es azufre y A es > C - R'', R y R'' representan conjuntamente el grupo - CH = CH - CH = CH -que puede, eventualmente, sustituirse por un átomo de halógeno o por uno o varios radiales alquilo o alcoxi, teniendo cada uno de 1 a 5 átomos de carbono, con el fin de formar con el grupo tiazolilo al cual están unidos un radical benzotiazolilo eventualmente sustituido, y de sus sales de adición con agentes alcalinos apropiados, caracterizado porque se hacen reaccionar las piperazinas N-monosustituídas de fórmula general II: **(Fórmula-02)** en la cual A, B y R tienen los significados definidos anteriormente con un exceso de sulfuro de carbono y, si se desea, se tratan los derivados así obtenidos con agentes alcalinos compatibles para dar las sales de adición correspondiente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2437077 | 1977-06-10 | ||
| GB3085177 | 1977-07-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES470679A1 true ES470679A1 (es) | 1979-03-16 |
Family
ID=26257079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES470679A Expired ES470679A1 (es) | 1977-06-10 | 1978-06-09 | Procedimiento de preparacion de nuevos derivados del acido piperazinacarboditioico |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS545987A (es) |
| AT (1) | AT360545B (es) |
| AU (1) | AU3692878A (es) |
| CA (1) | CA1098524A (es) |
| DE (1) | DE2825407C3 (es) |
| ES (1) | ES470679A1 (es) |
| FR (1) | FR2393802A1 (es) |
| GR (1) | GR63662B (es) |
| IT (1) | IT1104750B (es) |
| NL (1) | NL7806321A (es) |
| NZ (1) | NZ187474A (es) |
| PT (1) | PT68159A (es) |
| YU (1) | YU135378A (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0005091B1 (fr) * | 1978-04-13 | 1981-11-25 | SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE | Nouvelles pipérazines monosubstituées, leurs procédés de préparation et les compositions pharmaceutiques les renfermant |
| JP2002519346A (ja) * | 1998-06-30 | 2002-07-02 | ニューロゲン コーポレイション | １−（ベンゾチアゾール−２−イル）−４−（１−フェニルメチル）ピペラジン：ドーパミン受容体サブタイプ特異リガンド |
| CN101410385B (zh) | 2006-03-28 | 2011-08-24 | 高点制药有限责任公司 | 具有组胺h3受体活性的苯并噻唑类 |
| US20110224187A1 (en) * | 2008-10-16 | 2011-09-15 | Anandan Palani | Pyrrolidine, piperidine and piperazine derivatives and methods of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1307256A (en) | 1970-09-15 | 1973-02-14 | Science Union & Cie | Piperazine derivatives and a process for their preparation |
| CH583232A5 (es) | 1973-02-02 | 1976-12-31 | Wander Ag Dr A | |
| GB1432660A (en) | 1973-10-30 | 1976-04-22 | Science Union & Cie | Piperazine derivatives processes for their preparation and and pharamacueitcal compositions containing them |
-
1978
- 1978-06-06 NZ NZ187474A patent/NZ187474A/xx unknown
- 1978-06-06 YU YU01353/78A patent/YU135378A/xx unknown
- 1978-06-08 AU AU36928/78A patent/AU3692878A/en active Pending
- 1978-06-08 IT IT49764/78A patent/IT1104750B/it active
- 1978-06-08 CA CA305,059A patent/CA1098524A/fr not_active Expired
- 1978-06-08 GR GR56478A patent/GR63662B/el unknown
- 1978-06-09 PT PT68159A patent/PT68159A/pt unknown
- 1978-06-09 DE DE2825407A patent/DE2825407C3/de not_active Expired
- 1978-06-09 ES ES470679A patent/ES470679A1/es not_active Expired
- 1978-06-09 AT AT420878A patent/AT360545B/de not_active IP Right Cessation
- 1978-06-09 FR FR787817256A patent/FR2393802A1/fr active Granted
- 1978-06-09 JP JP6975378A patent/JPS545987A/ja active Pending
- 1978-06-09 NL NL7806321A patent/NL7806321A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATA420878A (de) | 1980-06-15 |
| NL7806321A (nl) | 1978-12-12 |
| AU3692878A (en) | 1979-12-13 |
| JPS545987A (en) | 1979-01-17 |
| DE2825407C3 (de) | 1981-04-30 |
| FR2393802B1 (es) | 1981-04-17 |
| CA1098524A (fr) | 1981-03-31 |
| FR2393802A1 (fr) | 1979-01-05 |
| YU135378A (en) | 1982-08-31 |
| IT7849764A0 (it) | 1978-06-08 |
| GR63662B (en) | 1979-11-28 |
| DE2825407A1 (de) | 1978-12-14 |
| PT68159A (fr) | 1978-07-01 |
| DE2825407B2 (de) | 1980-07-10 |
| IT1104750B (it) | 1985-10-28 |
| NZ187474A (en) | 1981-03-16 |
| AT360545B (de) | 1981-01-12 |
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