ES470412A1 - Procedimiento para la preparacion de analogos de prostaci- clina - Google Patents

Procedimiento para la preparacion de analogos de prostaci- clina

Info

Publication number
ES470412A1
ES470412A1 ES470412A ES470412A ES470412A1 ES 470412 A1 ES470412 A1 ES 470412A1 ES 470412 A ES470412 A ES 470412A ES 470412 A ES470412 A ES 470412A ES 470412 A1 ES470412 A1 ES 470412A1
Authority
ES
Spain
Prior art keywords
lower alkyl
nco2m
prostacycline
analogue
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES470412A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Chicago
Original Assignee
University of Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/835,731 external-priority patent/US4219647A/en
Application filed by University of Chicago filed Critical University of Chicago
Publication of ES470412A1 publication Critical patent/ES470412A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)

Abstract

Procedimiento para la preparación de análogos de prostaciclina de la fórmula **(formula-01)** en que **(formula-02)** n es un número entero de 2 a 5; M es hidrógeno, alquilo inferior, aralquilo, un metal de álcali o un catión de amonio; Q es hidrógeno, alquilo inferior o acilo; Z es hidrógeno o alquilo inferior; X es hidrógeno u fluor; R es alquilo inferior o alquenilo de 3 a 6 átomos de carbono; e Y es halógeno.
ES470412A 1977-06-06 1978-06-01 Procedimiento para la preparacion de analogos de prostaci- clina Expired ES470412A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80374777A 1977-06-06 1977-06-06
US05/835,731 US4219647A (en) 1977-09-22 1977-09-22 Certain amides of prostacyclin and related compounds

Publications (1)

Publication Number Publication Date
ES470412A1 true ES470412A1 (es) 1979-09-01

Family

ID=27122627

Family Applications (1)

Application Number Title Priority Date Filing Date
ES470412A Expired ES470412A1 (es) 1977-06-06 1978-06-01 Procedimiento para la preparacion de analogos de prostaci- clina

Country Status (8)

Country Link
JP (1) JPS543056A (es)
AU (1) AU3583378A (es)
DE (1) DE2824555A1 (es)
ES (1) ES470412A1 (es)
FR (1) FR2393800A1 (es)
IL (1) IL54697A0 (es)
IT (1) IT1104728B (es)
SE (1) SE7806565L (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU524786B2 (en) * 1977-03-07 1982-10-07 The Upjohn Company Prostacyclins
IT1099575B (it) * 1978-07-20 1985-09-18 Erba Carlo Spa 20-metil-13,14-deidro-pgi2' suoi sali e suoi 16s- e 16r-metil derivati
JPS59153522A (ja) * 1983-02-22 1984-09-01 Nippon Sharyo Seizo Kaisha Ltd 点熱式自動歪取装置

Also Published As

Publication number Publication date
IT7849713A0 (it) 1978-06-05
DE2824555A1 (de) 1978-12-14
AU3583378A (en) 1979-11-08
IT1104728B (it) 1985-10-28
JPS543056A (en) 1979-01-11
FR2393800A1 (fr) 1979-01-05
SE7806565L (sv) 1978-12-07
IL54697A0 (en) 1978-07-31

Similar Documents

Publication Publication Date Title
CA1273019C (en) ENKEPHALINASE INHIBITORS
HUP0003250A1 (hu) Káliumcsatorna gátló hatású indánszármazékok és az ezeket tartalmazó gyógyszerkészítmények
MX9206008A (es) Inhibidores de enzima proteolitica, derivados de sacarina 2-substituida.
DE69630214D1 (de) Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
NO843836L (no) Terapeutisk aktive sulfamatderivater
ES8101385A1 (es) Un procedimiento para la preparacion de un derivado de una enzima fibrinolitica
ATE251613T1 (de) Pyrimidinonderivate zur behandlung von atheroscleros
DK130387D0 (da) Transglutaminase inhibitorer
FI943728A0 (fi) Enkefalinaasin ja ACE:n inhibiittoreina käyttökelpoisia uusia aminoasetyylimerkaptojohdannaisia
GB1525449A (en) Cosmetic preparation containing agents for keeping the skin moist
ES547826A0 (es) Un procedimiento para preparar nuevos derivados de 6-(4-fenilo sustituido -3(2h) piradazinona.
FR2656610B1 (fr) Derives d'amino-2 phenyl-4 thiazole, leur procede de preparation et leur application therapeutique.
DE3887151D1 (de) Inhibitoren für zellenzuwachs und methoden für krebsbehandlung.
DE3677471D1 (de) Pyrrolidinylamidesterderivate mit antiprolylendopeptidaseaktivitaet, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische zubereitungen.
GEP19971017B (en) Process of preparation of benzocycloalkenyldihydroxyalkanoic acids derivatives
EA200000320A1 (ru) Изохинолины в качестве ингибиторов урокиназы
ES470412A1 (es) Procedimiento para la preparacion de analogos de prostaci- clina
GB1424450A (en) Isoindoline intermediates
ES2090934T3 (es) Nuevos derivados de beta-aminoacidos con actividad antitrombotica.
UA7051A1 (uk) N-[6-метоксі-5-(перфторалкін)-1-нафтоіл]-n-метілгліцин чи його тіонафтоільні аналоги як інгібітори албдозоредуктази
GB1390715A (en) Coumarin derivatives
GB1513883A (en) 3-(4-amino-and 4-acylamino-piperazin-1-ylalkyl)indoles
ATE79017T1 (de) Verwendung von amphoteren und zwitterionischen celluloseethern in haarpflegemitteln.
MD554G2 (ro) Derivaţi noi ai triazolpirimidinelor, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice care le conţin
ES427277A1 (es) Un procedimiento para la preparacion de un nuevo derivado de mercaptometilpiridina.