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Anphar SA
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Anphar SA
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Priority to ES469854ApriorityCriticalpatent/ES469854A1/en
Publication of ES469854A1publicationCriticalpatent/ES469854A1/en
Procedure for the preparation of cephalosporin salts, of general structure. **(See formula)** wherein R1 is a hydrogen atom or a hydroxyl group, and R2 is a chlorine atom or a methyl group, with amino acids of structure: **(See formula)** wherein R3 is a 2-aminoethyl, 3-aminopropyl, imidazol-4-yl or 2-guanidinoethyl group, characterized in that to a suspension of cephalosporin I in cold water between 2 and 10ºC is added little by little and with stirring amino acid II in stoichiometric amount, continuing to stir until complete dissolution; The water is subsequently separated by vacuum distillation, lyophilization or precipitation over an organic solvent such as acetone, thus isolating the solid product. (Machine-translation by Google Translate, not legally binding)
ES469854A1978-05-131978-05-13Procedure for preparation of cefalosporine salts. (Machine-translation by Google Translate, not legally binding)
ExpiredES469854A1
(en)
Pyrimido(1,6-a)indole derivatives and intermediates therefor, processes for their preparation, pharmaceutical compositions containing the derivatives and their use
(2-Oxo-pyrrolidine-1)- and (2-oxo- piperidine-1) carboxylic acid hydrazides, process for the manufacture thereof, and pharmaceutical preparations containing them
Procedure for the preparation of the acid 7- (d - &- amino- (4hydroxypenyl) -acetamido-3-methyl-3-cefem-4-carboxylic. (Machine-translation by Google Translate, not legally binding)