ES466646A1 - Thienamycin derivatives - Google Patents

Thienamycin derivatives

Info

Publication number
ES466646A1
ES466646A1 ES466646A ES466646A ES466646A1 ES 466646 A1 ES466646 A1 ES 466646A1 ES 466646 A ES466646 A ES 466646A ES 466646 A ES466646 A ES 466646A ES 466646 A1 ES466646 A1 ES 466646A1
Authority
ES
Spain
Prior art keywords
thienamycin derivatives
image
thienamycin
derivatives
deacetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES466646A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES466646A1 publication Critical patent/ES466646A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Abstract

Antibiotic deacetyl 890A10 of the structure < IMAGE > and its pharmaceutically acceptable salts it is produced from the compound 890A10 of the structure < IMAGE > by treatment with an enzyme which is capable of hydrolysing the N-acetyl group.
ES466646A 1977-02-11 1978-02-03 Thienamycin derivatives Expired ES466646A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76772377A 1977-02-11 1977-02-11

Publications (1)

Publication Number Publication Date
ES466646A1 true ES466646A1 (en) 1980-12-16

Family

ID=25080357

Family Applications (1)

Application Number Title Priority Date Filing Date
ES466646A Expired ES466646A1 (en) 1977-02-11 1978-02-03 Thienamycin derivatives

Country Status (10)

Country Link
JP (1) JPS53101395A (en)
CH (1) CH637960A5 (en)
DE (1) DE2805701A1 (en)
DK (1) DK40578A (en)
ES (1) ES466646A1 (en)
FR (1) FR2380280A1 (en)
GB (1) GB1595234A (en)
IT (1) IT7847912A0 (en)
NL (1) NL7800957A (en)
SE (1) SE7800978L (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7800979L (en) * 1977-02-11 1978-08-12 Merck & Co Inc ANTIBIOTIC
PH16708A (en) 1978-07-24 1984-01-20 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates
US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
EP0008888B1 (en) * 1978-08-23 1983-09-21 Beecham Group Plc Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK497476A (en) * 1975-11-24 1977-05-25 Merck & Co Inc PROCEDURE FOR THE PREPARATION OF AN ANTIBIOTIC SUBSTANCE
SE7800979L (en) * 1977-02-11 1978-08-12 Merck & Co Inc ANTIBIOTIC

Also Published As

Publication number Publication date
FR2380280A1 (en) 1978-09-08
NL7800957A (en) 1978-08-15
FR2380280B1 (en) 1980-05-16
DE2805701A1 (en) 1978-08-17
GB1595234A (en) 1981-08-12
DK40578A (en) 1978-08-12
JPS53101395A (en) 1978-09-04
SE7800978L (en) 1978-08-12
IT7847912A0 (en) 1978-02-03
CH637960A5 (en) 1983-08-31

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