ES466645A1 - Un procedimiento para la produccion de desacetildihidro 890a9 - Google Patents
Un procedimiento para la produccion de desacetildihidro 890a9Info
- Publication number
- ES466645A1 ES466645A1 ES466645A ES466645A ES466645A1 ES 466645 A1 ES466645 A1 ES 466645A1 ES 466645 A ES466645 A ES 466645A ES 466645 A ES466645 A ES 466645A ES 466645 A1 ES466645 A1 ES 466645A1
- Authority
- ES
- Spain
- Prior art keywords
- dihydro
- acetyl
- amidohydrolase
- microorganisms
- cpd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 244000005700 microbiome Species 0.000 abstract 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 125000003047 N-acetyl group Chemical group 0.000 abstract 1
- PVCJKHHOXFKFRP-UHFFFAOYSA-N N-acetylethanolamine Chemical compound CC(=O)NCCO PVCJKHHOXFKFRP-UHFFFAOYSA-N 0.000 abstract 1
- 235000019730 animal feed additive Nutrition 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 239000000645 desinfectant Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención se refiere al nuevo antibiótico desaceril-dihidro-890A9, activo contra las bacterias Gram-positivas y Gram-negativas, que se obtiene por tratamiento de dihidro 890A9 con una N-acetil-890A9-amidohidrolasa producida por un microorganismo de la tierra aislado por técnicas de enriquecimiento. Esta invención también se refiere al procedimiento mediante el cual enzimáticamente desacetilado el dihidro-890A9
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76792077A | 1977-02-11 | 1977-02-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES466645A1 true ES466645A1 (es) | 1980-12-16 |
Family
ID=25080969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES466645A Expired ES466645A1 (es) | 1977-02-11 | 1978-02-03 | Un procedimiento para la produccion de desacetildihidro 890a9 |
Country Status (8)
Country | Link |
---|---|
JP (1) | JPS53103494A (es) |
DE (1) | DE2805724A1 (es) |
DK (1) | DK40678A (es) |
ES (1) | ES466645A1 (es) |
FR (1) | FR2380277A1 (es) |
IT (1) | IT1105282B (es) |
NL (1) | NL7800958A (es) |
SE (1) | SE7800979L (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7800957A (nl) * | 1977-02-11 | 1978-08-15 | Merck & Co Inc | Antibioticum desacetyl 890 a10, werkwijze ter bereiding daarvan en farmaceutische preparaten die dit antibioticum bevatten. |
US4162193A (en) * | 1977-08-19 | 1979-07-24 | Merck & Co., Inc. | Enzymatic cleavage of N-acyl-thienamycins |
US4880793A (en) * | 1978-07-24 | 1989-11-14 | Merck & Co., Inc. | Combination of thienamycin-type antibiotics with dipeptidase inhibitors |
NZ190994A (en) | 1978-07-24 | 1981-10-19 | Merck & Co Inc | Z-2-acylamino-3-monosubstituted propenoates |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK497476A (da) * | 1975-11-24 | 1977-05-25 | Merck & Co Inc | Fremgangsmade til fremstilling af et antibiotisk stof |
NL7800957A (nl) * | 1977-02-11 | 1978-08-15 | Merck & Co Inc | Antibioticum desacetyl 890 a10, werkwijze ter bereiding daarvan en farmaceutische preparaten die dit antibioticum bevatten. |
-
1978
- 1978-01-26 NL NL7800958A patent/NL7800958A/xx not_active Application Discontinuation
- 1978-01-26 SE SE7800979A patent/SE7800979L/xx unknown
- 1978-01-27 DK DK40678A patent/DK40678A/da not_active Application Discontinuation
- 1978-02-03 IT IT47913/78A patent/IT1105282B/it active
- 1978-02-03 ES ES466645A patent/ES466645A1/es not_active Expired
- 1978-02-09 FR FR7803667A patent/FR2380277A1/fr not_active Withdrawn
- 1978-02-10 DE DE19782805724 patent/DE2805724A1/de active Pending
- 1978-02-13 JP JP1527978A patent/JPS53103494A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
FR2380277A1 (fr) | 1978-09-08 |
DE2805724A1 (de) | 1978-08-17 |
JPS53103494A (en) | 1978-09-08 |
DK40678A (da) | 1978-08-12 |
SE7800979L (sv) | 1978-08-12 |
IT7847913A0 (it) | 1978-02-03 |
IT1105282B (it) | 1985-10-28 |
NL7800958A (nl) | 1978-08-15 |
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