ES460685A1 - Catalytic dehalogenation process for preparing quinazolines - Google Patents
Catalytic dehalogenation process for preparing quinazolinesInfo
- Publication number
- ES460685A1 ES460685A1 ES460685A ES460685A ES460685A1 ES 460685 A1 ES460685 A1 ES 460685A1 ES 460685 A ES460685 A ES 460685A ES 460685 A ES460685 A ES 460685A ES 460685 A1 ES460685 A1 ES 460685A1
- Authority
- ES
- Spain
- Prior art keywords
- quinazolines
- preparing
- blood pressure
- catalytic dehalogenation
- dehalogenation process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Novel compounds of the general formula II < IMAGE > in which X represents a chlorine, bromine or iodine atom, and n denotes an integer from 1 to 3, are obtained by reacting a 6,7-dimethoxyquinazoline with a halogen-substituted furan. The compounds obtained can then be reacted at a temperature from 0 DEG to 150 DEG C with hydrogen in the presence of a catalytic amount of a dehalogenating catalyst and in the presence of a solvent which is inert to the reaction. The compound 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxy-quinazoline which can be prepared according to the invention is in general useful on account of its ability to lower the blood pressure in mammals having high blood pressure.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71227776A | 1976-08-06 | 1976-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES460685A1 true ES460685A1 (en) | 1978-07-01 |
Family
ID=24861452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES460685A Expired ES460685A1 (en) | 1976-08-06 | 1977-07-13 | Catalytic dehalogenation process for preparing quinazolines |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS5321181A (en) |
| AR (1) | AR213317A1 (en) |
| BE (1) | BE857491A (en) |
| CA (1) | CA1065317A (en) |
| CH (1) | CH633794A5 (en) |
| CS (1) | CS202074B2 (en) |
| DD (1) | DD131855A5 (en) |
| DE (1) | DE2731737A1 (en) |
| DK (1) | DK143601C (en) |
| ES (1) | ES460685A1 (en) |
| FI (1) | FI65999C (en) |
| FR (1) | FR2360591A1 (en) |
| GB (1) | GB1526180A (en) |
| GR (1) | GR69201B (en) |
| HK (1) | HK30281A (en) |
| HU (1) | HU177714B (en) |
| IE (1) | IE45776B1 (en) |
| IL (1) | IL52394A0 (en) |
| LU (1) | LU77925A1 (en) |
| MY (1) | MY8100264A (en) |
| NL (1) | NL171448C (en) |
| NO (1) | NO147912C (en) |
| NZ (1) | NZ184535A (en) |
| PL (1) | PL104355B1 (en) |
| PT (1) | PT66796B (en) |
| RO (1) | RO73523A (en) |
| SE (2) | SE436032B (en) |
| YU (1) | YU39397B (en) |
| ZA (1) | ZA773898B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5793977A (en) * | 1980-11-26 | 1982-06-11 | Sankyo Co Ltd | Acylaminoquinazoline derivative and its preparation |
-
1977
- 1977-06-25 GR GR53808A patent/GR69201B/el unknown
- 1977-06-27 IL IL52394A patent/IL52394A0/en not_active IP Right Cessation
- 1977-06-27 CA CA281,453A patent/CA1065317A/en not_active Expired
- 1977-06-28 SE SE7707472A patent/SE436032B/en not_active IP Right Cessation
- 1977-06-28 ZA ZA00773898A patent/ZA773898B/en unknown
- 1977-06-30 NZ NZ184535A patent/NZ184535A/en unknown
- 1977-07-11 YU YU1715/77A patent/YU39397B/en unknown
- 1977-07-11 DE DE19772731737 patent/DE2731737A1/en active Pending
- 1977-07-13 NO NO772488A patent/NO147912C/en unknown
- 1977-07-13 CS CS774679A patent/CS202074B2/en unknown
- 1977-07-13 ES ES460685A patent/ES460685A1/en not_active Expired
- 1977-07-13 PT PT66796A patent/PT66796B/en unknown
- 1977-07-13 CH CH870177A patent/CH633794A5/en not_active IP Right Cessation
- 1977-07-13 NL NLAANVRAGE7707792,A patent/NL171448C/en not_active IP Right Cessation
- 1977-07-14 DK DK320077A patent/DK143601C/en not_active IP Right Cessation
- 1977-07-14 AR AR268434A patent/AR213317A1/en active
- 1977-07-14 FI FI772193A patent/FI65999C/en not_active IP Right Cessation
- 1977-07-27 JP JP9022777A patent/JPS5321181A/en active Pending
- 1977-08-03 GB GB32651/77A patent/GB1526180A/en not_active Expired
- 1977-08-04 HU HU77PI586A patent/HU177714B/en not_active IP Right Cessation
- 1977-08-04 LU LU77925A patent/LU77925A1/en unknown
- 1977-08-04 BE BE179921A patent/BE857491A/en not_active IP Right Cessation
- 1977-08-05 DD DD7700200469A patent/DD131855A5/en unknown
- 1977-08-05 PL PL1977200090A patent/PL104355B1/en unknown
- 1977-08-05 FR FR7724260A patent/FR2360591A1/en active Granted
- 1977-08-05 RO RO7791289A patent/RO73523A/en unknown
- 1977-08-05 IE IE1642/77A patent/IE45776B1/en not_active IP Right Cessation
-
1981
- 1981-07-02 HK HK302/81A patent/HK30281A/en unknown
- 1981-12-30 MY MY264/81A patent/MY8100264A/en unknown
-
1982
- 1982-06-09 SE SE8203583A patent/SE439162B/en not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980302 |