ES458756A1 - Procedimiento para preparar derivados de isotiourea. - Google Patents
Procedimiento para preparar derivados de isotiourea.Info
- Publication number
- ES458756A1 ES458756A1 ES458756A ES458756A ES458756A1 ES 458756 A1 ES458756 A1 ES 458756A1 ES 458756 A ES458756 A ES 458756A ES 458756 A ES458756 A ES 458756A ES 458756 A1 ES458756 A1 ES 458756A1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical compositions
- dimethylaminopropylthio
- isothioureas
- isothiourea
- imidazoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- KMFBOMKUKPBRBH-UHFFFAOYSA-N 3-(4,5-dihydro-1h-imidazol-2-ylsulfanyl)-n,n-dimethylpropan-1-amine Chemical compound CN(C)CCCSC1=NCCN1 KMFBOMKUKPBRBH-UHFFFAOYSA-N 0.000 abstract 1
- BVCBJBVDMXCOJC-UHFFFAOYSA-N 3-(dimethylamino)propyl n,n'-dimethylcarbamimidothioate Chemical compound CNC(=NC)SCCCN(C)C BVCBJBVDMXCOJC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001861 immunosuppressant effect Effects 0.000 abstract 1
- 150000002541 isothioureas Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/42—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB19994/76A GB1592453A (en) | 1976-05-14 | 1976-05-14 | Aminoalkyl esters of carbarimidothioic acid and compositions having immunosuppressant activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES458756A1 true ES458756A1 (es) | 1978-03-01 |
Family
ID=10138568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES458756A Expired ES458756A1 (es) | 1976-05-14 | 1977-05-13 | Procedimiento para preparar derivados de isotiourea. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4294854A (OSRAM) |
| JP (1) | JPS532420A (OSRAM) |
| AR (1) | AR218872A1 (OSRAM) |
| AT (1) | AT359521B (OSRAM) |
| AU (1) | AU509573B2 (OSRAM) |
| BE (1) | BE854553A (OSRAM) |
| CA (1) | CA1086758A (OSRAM) |
| CH (1) | CH620203A5 (OSRAM) |
| DE (1) | DE2721830A1 (OSRAM) |
| DK (1) | DK211277A (OSRAM) |
| ES (1) | ES458756A1 (OSRAM) |
| FI (1) | FI771400A7 (OSRAM) |
| FR (2) | FR2351098A1 (OSRAM) |
| GB (1) | GB1592453A (OSRAM) |
| HU (1) | HU174978B (OSRAM) |
| IE (1) | IE45144B1 (OSRAM) |
| IL (1) | IL52011A (OSRAM) |
| LU (1) | LU77332A1 (OSRAM) |
| NL (1) | NL7705331A (OSRAM) |
| NO (1) | NO771697L (OSRAM) |
| PT (1) | PT66509B (OSRAM) |
| SE (1) | SE7705658L (OSRAM) |
| ZA (1) | ZA772612B (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0672244B2 (ja) * | 1984-12-12 | 1994-09-14 | 三菱マテリアル株式会社 | 貴金属造粒装置 |
| AU695120B2 (en) * | 1993-06-07 | 1998-08-06 | Baylor College Of Medicine | Use of an MHC class I suppressor drug for the treatment of autoimmune diseases and transplantation rejection |
| AU3230895A (en) * | 1994-08-18 | 1996-03-14 | Chugai Seiyaku Kabushiki Kaisha | Amino acid derivative having nitrogen monoxide synthetase inhibitor activity |
| US7645873B2 (en) * | 2003-03-20 | 2010-01-12 | The Scripps Research Institute | 6″-amino-6″-deoxygalactosylceramides |
| EP2058011A1 (en) * | 2007-11-07 | 2009-05-13 | Wittycell | Nkt cell activating gycolipids covalently bound antigens and/or drug |
| WO2010040710A1 (en) * | 2008-10-08 | 2010-04-15 | Wittycell | Vaccine composition for use against influenza |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2648710A (en) * | 1950-09-22 | 1953-08-11 | Hoffmann La Roche | Bis-quaternary salts of 1:10-bis-(dialkylamino)-5:6-dithia-decane |
| US2813102A (en) * | 1956-04-10 | 1957-11-12 | American Home Prod | 2-(di-lower alkylaminoethylmercapto)-imidazolines and their acid addition salts and preparation thereof |
| US4152453A (en) * | 1975-12-01 | 1979-05-01 | Smith Kline & French Laboratories Limited | Pharmacologically active compounds and compositions and methods of use |
-
1976
- 1976-05-14 GB GB19994/76A patent/GB1592453A/en not_active Expired
-
1977
- 1977-05-02 ZA ZA00772612A patent/ZA772612B/xx unknown
- 1977-05-03 FI FI771400A patent/FI771400A7/fi not_active Application Discontinuation
- 1977-05-04 AT AT318277A patent/AT359521B/de not_active IP Right Cessation
- 1977-05-04 PT PT66509A patent/PT66509B/pt unknown
- 1977-05-04 IL IL52011A patent/IL52011A/xx unknown
- 1977-05-10 IE IE947/77A patent/IE45144B1/en unknown
- 1977-05-11 JP JP5483077A patent/JPS532420A/ja active Pending
- 1977-05-11 CH CH589877A patent/CH620203A5/fr not_active IP Right Cessation
- 1977-05-11 AU AU25079/77A patent/AU509573B2/en not_active Expired
- 1977-05-12 BE BE177510A patent/BE854553A/xx not_active IP Right Cessation
- 1977-05-13 NL NL7705331A patent/NL7705331A/xx not_active Application Discontinuation
- 1977-05-13 DE DE19772721830 patent/DE2721830A1/de not_active Withdrawn
- 1977-05-13 ES ES458756A patent/ES458756A1/es not_active Expired
- 1977-05-13 LU LU77332A patent/LU77332A1/xx unknown
- 1977-05-13 CA CA278,412A patent/CA1086758A/en not_active Expired
- 1977-05-13 NO NO771697A patent/NO771697L/no unknown
- 1977-05-13 DK DK211277A patent/DK211277A/da not_active Application Discontinuation
- 1977-05-13 AR AR267623A patent/AR218872A1/es active
- 1977-05-13 FR FR7714766A patent/FR2351098A1/fr active Granted
- 1977-05-13 HU HU77SI1576A patent/HU174978B/hu unknown
- 1977-05-16 SE SE7705658A patent/SE7705658L/xx unknown
-
1979
- 1979-10-09 US US06/082,836 patent/US4294854A/en not_active Expired - Lifetime
-
1980
- 1980-11-17 FR FR8024334A patent/FR2472935A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| BE854553A (fr) | 1977-11-14 |
| JPS532420A (en) | 1978-01-11 |
| HU174978B (hu) | 1980-04-28 |
| AT359521B (de) | 1980-11-10 |
| NL7705331A (nl) | 1977-11-16 |
| PT66509A (en) | 1977-06-01 |
| ATA318277A (de) | 1980-04-15 |
| SE7705658L (sv) | 1977-11-15 |
| FR2472935A1 (fr) | 1981-07-10 |
| FR2351098A1 (fr) | 1977-12-09 |
| AU509573B2 (en) | 1980-05-15 |
| IL52011A (en) | 1982-05-31 |
| PT66509B (en) | 1978-10-16 |
| IE45144B1 (en) | 1982-06-30 |
| ZA772612B (en) | 1978-04-26 |
| US4294854A (en) | 1981-10-13 |
| IE45144L (en) | 1977-11-14 |
| CA1086758A (en) | 1980-09-30 |
| DK211277A (da) | 1977-11-15 |
| FR2351098B1 (OSRAM) | 1982-06-18 |
| FI771400A7 (OSRAM) | 1977-11-15 |
| LU77332A1 (OSRAM) | 1977-08-29 |
| AU2507977A (en) | 1978-11-16 |
| CH620203A5 (OSRAM) | 1980-11-14 |
| AR218872A1 (es) | 1980-07-15 |
| NO771697L (no) | 1977-11-15 |
| DE2721830A1 (de) | 1977-11-24 |
| GB1592453A (en) | 1981-07-08 |
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