ES457563A1 - Dipeptide derivatives - Google Patents

Dipeptide derivatives

Info

Publication number
ES457563A1
ES457563A1 ES457563A ES457563A ES457563A1 ES 457563 A1 ES457563 A1 ES 457563A1 ES 457563 A ES457563 A ES 457563A ES 457563 A ES457563 A ES 457563A ES 457563 A1 ES457563 A1 ES 457563A1
Authority
ES
Spain
Prior art keywords
activity
carboxylic acid
image
compounds
psychostimulants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES457563A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of ES457563A1 publication Critical patent/ES457563A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

Abstract

The compounds correspond to the formula: < IMAGE > in which the symbols R1 to R5 have the meanings given in Claim 1. The preparation is effected by forming the amide bond in accordance with one of four process variants, starting from amino compounds of the formulae: < IMAGE > and the carboxylic acid corresponding in each case to the remainder of the molecule. The reaction is also carried out using functional derivatives of the carboxylic acid or with the 1 and 3 positions of the imidazole group in the histidyl residue being temporarily protected. The compounds show a spectrum of activity which is similar to that of thyrotropin-releasing hormone, but with a longer duration of activity and a stronger stimulatory effect on the central nervous system they can be used therapeutically as psychostimulants and as antidepressants.
ES457563A 1976-04-09 1977-04-05 Dipeptide derivatives Expired ES457563A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2615455A DE2615455C2 (en) 1976-04-09 1976-04-09 N-acyl-L-histidyl-L-proline (N-substituted) amides, processes for their preparation and pharmaceutical preparations containing these compounds

Publications (1)

Publication Number Publication Date
ES457563A1 true ES457563A1 (en) 1978-03-16

Family

ID=5974903

Family Applications (1)

Application Number Title Priority Date Filing Date
ES457563A Expired ES457563A1 (en) 1976-04-09 1977-04-05 Dipeptide derivatives

Country Status (17)

Country Link
JP (1) JPS52125166A (en)
AT (1) AT352921B (en)
AU (1) AU2322677A (en)
BE (1) BE853444A (en)
CA (1) CA1088520A (en)
CH (1) CH632737A5 (en)
DE (1) DE2615455C2 (en)
DK (1) DK148902C (en)
ES (1) ES457563A1 (en)
FR (1) FR2347338A1 (en)
GB (1) GB1564078A (en)
IE (1) IE44485B1 (en)
NL (1) NL7703789A (en)
PT (1) PT66283B (en)
SE (1) SE427835B (en)
YU (1) YU85977A (en)
ZA (1) ZA771097B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58849B1 (en) * 1984-12-18 1993-11-17 Gruenenthal Chemie Use of dipeptide derivatives for the manufacture of medicaments for the treatment of patients with amyotrophic lateral sclerosis
DE3502041A1 (en) 1985-01-23 1986-07-24 Grünenthal GmbH, 5190 Stolberg USE OF DIPEPTIDE DERIVATIVES FOR THE TREATMENT OF POSTTRAUMATIC NERVOUS DAMAGE
JPS63316724A (en) * 1987-06-19 1988-12-26 Nippon Shinyaku Co Ltd Anticonvulsant
US5151497A (en) * 1989-02-21 1992-09-29 Japan Tobacco Inc. Histidyl peptide derivatives
US6039956A (en) * 1994-09-12 2000-03-21 Pennsylvania, Trustees Of The University Of, The Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder
CA2199734A1 (en) * 1994-09-12 1996-03-21 Fraser Aird Corticotropin release inhibiting factor and methods of using same

Also Published As

Publication number Publication date
AT352921B (en) 1979-10-10
DK148902B (en) 1985-11-11
IE44485B1 (en) 1981-12-16
PT66283A (en) 1977-04-01
BE853444A (en) 1977-08-01
AU2322677A (en) 1978-09-21
SE427835B (en) 1983-05-09
YU85977A (en) 1982-10-31
ZA771097B (en) 1978-01-25
JPS52125166A (en) 1977-10-20
JPS6110479B2 (en) 1986-03-29
ATA113977A (en) 1979-03-15
CA1088520A (en) 1980-10-28
CH632737A5 (en) 1982-10-29
NL7703789A (en) 1977-10-11
DE2615455C2 (en) 1985-06-20
GB1564078A (en) 1980-04-02
FR2347338A1 (en) 1977-11-04
SE7704088L (en) 1977-10-10
DE2615455A1 (en) 1977-10-20
FR2347338B1 (en) 1980-07-11
IE44485L (en) 1977-10-09
DK148902C (en) 1986-06-09
DK157077A (en) 1977-10-10
PT66283B (en) 1978-08-09

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990405