ES455696A1 - Procedimiento de produccion de una solucion estable e inyec-table que contenga una sulfonamida y un potenciador. - Google Patents

Procedimiento de produccion de una solucion estable e inyec-table que contenga una sulfonamida y un potenciador.

Info

Publication number
ES455696A1
ES455696A1 ES455696A ES455696A ES455696A1 ES 455696 A1 ES455696 A1 ES 455696A1 ES 455696 A ES455696 A ES 455696A ES 455696 A ES455696 A ES 455696A ES 455696 A1 ES455696 A1 ES 455696A1
Authority
ES
Spain
Prior art keywords
potentiator
sulphonamide
producing stable
stable solutions
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES455696A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rosco AS
Original Assignee
Rosco AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosco AS filed Critical Rosco AS
Publication of ES455696A1 publication Critical patent/ES455696A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procedimiento de producción de una solución estable e inyectable que contenga una sulfonamida y un potenciador, caracterizado porque la sulfonamida, bajo la forma de su sal dietanolamina, y una sal del potenciador, son disueltas en una mezcla de agua, propilenoglicol y N-metilpirrolidona, siendo el contenido acuoso del preparado del 10% al 50% p/v, el contenido en propilenoglicol del 15% al 30% p/v y el contenido en N-metilpirrolidona del 20% al 40% p/v; seguidamente se ajusta el pH entre 5,5 y 7,5.
ES455696A 1976-02-06 1977-02-05 Procedimiento de produccion de una solucion estable e inyec-table que contenga una sulfonamida y un potenciador. Expired ES455696A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK49776AA DK136934B (da) 1976-02-06 1976-02-06 Fremgangsmåde til fremstilling af en klar, stabil, injicerbar opløsning indeholdende et sulfonamid og en potentiator.

Publications (1)

Publication Number Publication Date
ES455696A1 true ES455696A1 (es) 1978-01-01

Family

ID=8094229

Family Applications (1)

Application Number Title Priority Date Filing Date
ES455696A Expired ES455696A1 (es) 1976-02-06 1977-02-05 Procedimiento de produccion de una solucion estable e inyec-table que contenga una sulfonamida y un potenciador.

Country Status (15)

Country Link
US (1) US4133879A (es)
AT (1) AT347579B (es)
AU (1) AU512299B2 (es)
BE (1) BE851060A (es)
CA (1) CA1092970A (es)
DE (1) DE2704708A1 (es)
DK (1) DK136934B (es)
ES (1) ES455696A1 (es)
FR (1) FR2340100A1 (es)
GB (1) GB1522571A (es)
NL (1) NL186847C (es)
NO (1) NO145043C (es)
NZ (1) NZ183224A (es)
SE (1) SE436396B (es)
ZA (1) ZA77531B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2631780C3 (de) * 1976-07-15 1981-11-19 Basf Ag, 6700 Ludwigshafen Sulfonamid-Trimethoprim-Lösungen
EP0007591B1 (de) * 1978-08-01 1982-07-28 Ciba-Geigy Ag Stabile flüssige Arzneimittelformulierung auf Basis von 2,6-Diamino-5-(3',4',5'-trimethoxybenzyl)-pyrimidin(Trimethoprim) und einem Sulfonamid, Verfahren zu ihrer Herstellung und ihre Verwendung
IE49934B1 (en) * 1979-07-02 1986-01-08 Pfizer Long acting sulfonamide injectable compositions
ATE3750T1 (de) * 1979-07-05 1983-06-15 Pfizer Inc. Sulfonamidloesungen.
HU180740B (en) * 1979-11-27 1983-04-29 Egyt Gyogyszervegyeszeti Gyar Process for producing sulfonamide-containing,injectable pharmaceutical composition of prolongated activity
HU212498B (en) 1992-11-06 1996-07-29 Egyt Gyogyszervegyeszeti Gyar Process for producing water-soluble pharmaceutical compositions, containing sulfachlorpyridazin-sodium and trimethoprim

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH544053A (de) * 1966-05-09 1973-11-15 Hoffmann La Roche Verfahren zur Herstellung von Sulfonamidderivaten
ZM3271A1 (en) * 1970-03-13 1972-10-23 Wellcome Found Improvements in or relating to injectable therapeutic compositions
US3985876A (en) * 1973-01-05 1976-10-12 Burroughs Wellcome Co. Chemotherapeutic solutions containing a sulphur and a salt of a 2,4-diamino-5-benzylpyrimidine
IL46406A (en) * 1975-01-08 1977-08-31 Abic Ltd The water-floating mixture containing robinidin

Also Published As

Publication number Publication date
AU512299B2 (en) 1980-10-02
NZ183224A (en) 1979-10-25
AT347579B (de) 1979-01-10
SE436396B (sv) 1984-12-10
ZA77531B (en) 1977-12-28
NO770386L (no) 1977-08-09
NL7701267A (nl) 1977-08-09
DK49776A (es) 1977-08-07
FR2340100A1 (fr) 1977-09-02
BE851060A (fr) 1977-05-31
ATA73577A (de) 1978-05-15
NO145043C (no) 1982-01-27
FR2340100B1 (es) 1981-07-10
US4133879A (en) 1979-01-09
DE2704708A1 (de) 1977-08-11
AU2190977A (en) 1978-08-10
SE7701218L (sv) 1977-08-07
NO145043B (no) 1981-09-21
GB1522571A (en) 1978-08-23
NL186847C (nl) 1991-03-18
CA1092970A (en) 1981-01-06
DK136934C (es) 1982-03-22
DK136934B (da) 1977-12-19

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