ES455346A1 - Procedimiento para preparar derivados de pirrolidinetanol. - Google Patents

Procedimiento para preparar derivados de pirrolidinetanol.

Info

Publication number
ES455346A1
ES455346A1 ES455346A ES455346A ES455346A1 ES 455346 A1 ES455346 A1 ES 455346A1 ES 455346 A ES455346 A ES 455346A ES 455346 A ES455346 A ES 455346A ES 455346 A1 ES455346 A1 ES 455346A1
Authority
ES
Spain
Prior art keywords
formula
group
carbon atoms
salts
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES455346A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES455346A1 publication Critical patent/ES455346A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedimiento para preparar derivados de pirrolidinetanol, de fórmula Ia, **fórmula** en donde R1'' es un grupo alquilo con 4 a 8 átomos de carbono, un grupo ciclalquilo con 4 a 6 átomos de carbono, un grupo fenetilo que puede estar facultativamente monosustituido en la posición o, m o p del radical fenilo por flúor, cloro, bromo, metoxi o alquilo con 1 a 4 átomos de carbono o 2-tetrahidrofurilmetilo y sus sales, caracterizado porque comprende someter a reacción de hidrogenólisis un compuesto de fórmula II **fórmula** en dónde R''1 tiene el significado previamente indicado, y R2 significa un grupo protector éter capaz de ser escindido hidrogenolíticamente, para separar dicho grupo R2, convenientemente en un disolvente orgánico inerte, y en presencia de un catalizador, tal como de platino, níquel o paladio, a temperaturas entre 20 y 60ºC , bajo una presión de hidrógeno de 1 a 200 atmósferas y si se desea, se convierten los compuestos de fórmula Ia resultantes en sus sales.
ES455346A 1976-01-28 1977-01-26 Procedimiento para preparar derivados de pirrolidinetanol. Expired ES455346A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH107176 1976-01-28
CH107076 1976-01-28

Publications (1)

Publication Number Publication Date
ES455346A1 true ES455346A1 (es) 1978-12-01

Family

ID=25686556

Family Applications (1)

Application Number Title Priority Date Filing Date
ES455346A Expired ES455346A1 (es) 1976-01-28 1977-01-26 Procedimiento para preparar derivados de pirrolidinetanol.

Country Status (12)

Country Link
US (1) US4094987A (es)
JP (1) JPS5293766A (es)
AU (1) AU2168677A (es)
DE (1) DE2701705A1 (es)
DK (1) DK20777A (es)
ES (1) ES455346A1 (es)
FI (1) FI770160A (es)
FR (1) FR2339598A1 (es)
IL (1) IL51334A0 (es)
NL (1) NL7700681A (es)
PT (1) PT66120A (es)
SE (1) SE7700606L (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU78625A1 (de) * 1977-12-02 1979-06-13 Byk Gulden Lomberg Chem Fab Substituierte 1-phenyl-2-pyrrolidin-2-yl-ethanole,verfahren zu ihrer herstellung,ihre verwendung und sie enthaltende arzneimittel
DD155065A5 (de) * 1979-12-05 1982-05-12 Astra Laekemedel Ab Verfahren zur herstellung von phenylazacycloalkanen
US5625060A (en) * 1991-05-03 1997-04-29 Elf Sanofi Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
US8183381B2 (en) 2007-07-19 2012-05-22 Metabolex Inc. N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders
US20110294836A1 (en) * 2008-06-20 2011-12-01 Metabolex, Inc. Aryl gpr119 agonists and uses thereof
CN102666553B (zh) 2009-10-01 2015-05-06 赛马拜制药公司 取代的四唑-1-基-苯氧基甲基-噻唑-2-基-哌啶基-嘧啶盐
CN103037843A (zh) 2010-06-23 2013-04-10 麦它波莱克斯股份有限公司 5-乙基-2-{4-[4-(4-四唑-1-基-苯氧甲基)-噻唑-2-基]-哌啶-1-基}-嘧啶的组合物
WO2018026890A1 (en) 2016-08-03 2018-02-08 Cymabay Therapeutics Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1283452A (en) * 1970-07-24 1972-07-26 Parke Davis & Co Substituted 1,3-dialkylpyrrolidines and processes for their production

Also Published As

Publication number Publication date
AU2168677A (en) 1978-08-03
FI770160A (es) 1977-07-29
US4094987A (en) 1978-06-13
PT66120A (fr) 1977-02-01
IL51334A0 (en) 1977-03-31
DK20777A (da) 1977-07-29
SE7700606L (sv) 1977-07-29
DE2701705A1 (de) 1977-08-04
NL7700681A (nl) 1977-08-01
JPS5293766A (en) 1977-08-06
FR2339598A1 (fr) 1977-08-26

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