ES453935A1 - Substituted phenylpiperazine compounds and pharmaceutical uses thereof - Google Patents

Substituted phenylpiperazine compounds and pharmaceutical uses thereof

Info

Publication number
ES453935A1
ES453935A1 ES453935A ES453935A ES453935A1 ES 453935 A1 ES453935 A1 ES 453935A1 ES 453935 A ES453935 A ES 453935A ES 453935 A ES453935 A ES 453935A ES 453935 A1 ES453935 A1 ES 453935A1
Authority
ES
Spain
Prior art keywords
formula
substituted
compounds
lowering
pharmaceutical uses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES453935A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES453935A1 publication Critical patent/ES453935A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Abstract

Novel substituted N-[1-(3,4-methylenedioxyphenyl)-propyl-(2)]-N'-phenylpiperazines of the formula I shown, wherein either R1 and R2 denote chlorine or R1 denotes methyl and R2 denotes methoxy, are prepared by treating an appropriately substituted halogenopropane, especially an appropriately substituted chloropropane, with catalytically activated hydrogen. Advantageously, the process is carried out in the presence of an acid-binding agent and at an elevated temperature. The compounds of the formula I may be obtained in the form of the racemates or of the optically active antipodes. The products of the process show a good central-depressant action as well as an excellent blood lipid level-lowering and cholesterol-lowering action.
ES453935A 1974-09-03 1976-12-03 Substituted phenylpiperazine compounds and pharmaceutical uses thereof Expired ES453935A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2442158A DE2442158C3 (en) 1974-09-03 1974-09-03 New substituted N- [1 (3,4-methylenedioxyphenyl) propyl (2)] -N'-subst phenylpiperazines

Publications (1)

Publication Number Publication Date
ES453935A1 true ES453935A1 (en) 1977-11-16

Family

ID=5924765

Family Applications (5)

Application Number Title Priority Date Filing Date
ES440630A Expired ES440630A1 (en) 1974-09-03 1975-09-02 Substituted phenylpiperazine compounds and pharmaceutical uses thereof
ES453933A Expired ES453933A1 (en) 1974-09-03 1976-12-03 Substituted phenylpiperazine compounds and pharmaceutical uses thereof
ES453934A Expired ES453934A1 (en) 1974-09-03 1976-12-03 Substituted phenylpiperazine compounds and pharmaceutical uses thereof
ES453935A Expired ES453935A1 (en) 1974-09-03 1976-12-03 Substituted phenylpiperazine compounds and pharmaceutical uses thereof
ES453932A Expired ES453932A1 (en) 1974-09-03 1976-12-03 Substituted phenylpiperazine compounds and pharmaceutical uses thereof

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES440630A Expired ES440630A1 (en) 1974-09-03 1975-09-02 Substituted phenylpiperazine compounds and pharmaceutical uses thereof
ES453933A Expired ES453933A1 (en) 1974-09-03 1976-12-03 Substituted phenylpiperazine compounds and pharmaceutical uses thereof
ES453934A Expired ES453934A1 (en) 1974-09-03 1976-12-03 Substituted phenylpiperazine compounds and pharmaceutical uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES453932A Expired ES453932A1 (en) 1974-09-03 1976-12-03 Substituted phenylpiperazine compounds and pharmaceutical uses thereof

Country Status (27)

Country Link
JP (1) JPS52287A (en)
AT (1) AT344699B (en)
BE (2) BE833002A (en)
BG (1) BG26381A3 (en)
CA (2) CA1061343A (en)
CH (1) CH615174A5 (en)
CS (1) CS192521B2 (en)
DD (1) DD124118A5 (en)
DE (1) DE2442158C3 (en)
DK (1) DK137387C (en)
ES (5) ES440630A1 (en)
FI (1) FI60006C (en)
FR (1) FR2283682A1 (en)
GB (3) GB1521052A (en)
HU (1) HU176754B (en)
IE (2) IE41667B1 (en)
IL (2) IL48033A (en)
LU (2) LU73317A1 (en)
NL (1) NL7510319A (en)
NO (1) NO142911C (en)
NZ (1) NZ178566A (en)
PH (1) PH13631A (en)
PL (1) PL95233B1 (en)
RO (1) RO68380B (en)
SE (1) SE419084B (en)
YU (1) YU37164B (en)
ZA (2) ZA755601B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54109307U (en) * 1978-01-19 1979-08-01
US4647606A (en) * 1982-12-27 1987-03-03 Owens-Corning Fiberglas Corporation Blend of rapid set asphaltic emulsion with slow set asphalt emulsion
HU187229B (en) * 1983-04-14 1985-11-28 Koezponti Valto Hitelbank Method for producing fodder increasing yield or additional fodder composition
AUPN359095A0 (en) * 1995-06-19 1995-07-13 Mount Shamrock Pty Ltd Saw system

Also Published As

Publication number Publication date
NL7510319A (en) 1976-03-05
DK137387B (en) 1978-02-27
RO68380B (en) 1983-04-30
BE833002A (en) 1976-03-02
YU37164B (en) 1984-08-31
ES453932A1 (en) 1977-11-01
GB1521051A (en) 1978-08-09
PL95233B1 (en) 1977-09-30
CA1061343A (en) 1979-08-28
DE2442158A1 (en) 1976-03-18
ATA653875A (en) 1977-12-15
LU73316A1 (en) 1977-01-28
RO68380A (en) 1983-04-29
ES453933A1 (en) 1977-11-16
AT344699B (en) 1978-08-10
FR2283682A1 (en) 1976-04-02
DK393775A (en) 1976-03-04
FI752288A (en) 1976-03-04
GB1521052A (en) 1978-08-09
AU8445675A (en) 1977-03-10
DD124118A5 (en) 1977-02-02
JPS52287A (en) 1977-01-05
NZ178566A (en) 1978-03-06
CS192521B2 (en) 1979-08-31
IE43338B1 (en) 1981-02-11
HU176754B (en) 1981-05-28
GB1514546A (en) 1978-06-14
NO142911C (en) 1980-11-12
FI60006B (en) 1981-07-31
FR2283682B1 (en) 1978-11-10
LU73317A1 (en) 1977-01-28
IE41667B1 (en) 1980-02-27
CH615174A5 (en) 1980-01-15
ZA755601B (en) 1977-05-25
IL48033A0 (en) 1975-11-25
FI60006C (en) 1981-11-10
BE833003A (en) 1976-03-02
DK137387C (en) 1978-09-04
NO142911B (en) 1980-08-04
BG26381A3 (en) 1979-03-15
ES453934A1 (en) 1977-11-16
IE41667L (en) 1976-03-03
YU221975A (en) 1983-04-27
NO753020L (en) 1976-03-04
DE2442158C3 (en) 1979-08-30
CA1063027A (en) 1979-09-25
IL48036A (en) 1978-07-31
AU8445575A (en) 1977-03-10
ZA755602B (en) 1977-05-25
SE419084B (en) 1981-07-13
PH13631A (en) 1980-08-14
IL48036A0 (en) 1975-11-25
IE43338L (en) 1976-03-03
SE7509746L (en) 1976-03-04
DE2442158B2 (en) 1979-01-04
IL48033A (en) 1978-07-31
ES440630A1 (en) 1977-06-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103