ES453136A1 - Stabilized erythrocytes and their use - Google Patents

Stabilized erythrocytes and their use

Info

Publication number
ES453136A1
ES453136A1 ES453136A ES453136A ES453136A1 ES 453136 A1 ES453136 A1 ES 453136A1 ES 453136 A ES453136 A ES 453136A ES 453136 A ES453136 A ES 453136A ES 453136 A1 ES453136 A1 ES 453136A1
Authority
ES
Spain
Prior art keywords
erythrocytes
coated
aldehyde
erythrocyte preparations
chromium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES453136A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of ES453136A1 publication Critical patent/ES453136A1/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • G01N33/555—Red blood cell
    • G01N33/556—Fixed or stabilised red blood cell
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dentistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Stable lyophilisable erythrocyte preparations are obtained by treating erythrocytes which are suspended in aqueous isotonic solutions with a lower aliphatic aldehyde and a water-soluble salt of 2- or 3-valent chromium. The treatment with aldehyde and the chromium salts can take place successively in any desired sequence or simultaneously. The treated erythrocytes are washed and, if required, lyophilised. The resulting stabilised erythrocyte preparations can be coated with antigen and antibodies too. The coated erythrocytes can be employed for haemagglutination tests.
ES453136A 1975-11-14 1976-11-09 Stabilized erythrocytes and their use Expired ES453136A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752551208 DE2551208C3 (en) 1975-11-14 1975-11-14 Process for the production of a stable erythrocyte preparation

Publications (1)

Publication Number Publication Date
ES453136A1 true ES453136A1 (en) 1978-01-16

Family

ID=5961771

Family Applications (1)

Application Number Title Priority Date Filing Date
ES453136A Expired ES453136A1 (en) 1975-11-14 1976-11-09 Stabilized erythrocytes and their use

Country Status (18)

Country Link
JP (1) JPS5261218A (en)
AR (1) AR213420A1 (en)
AT (1) AT356812B (en)
AU (1) AU511427B2 (en)
BE (1) BE848377A (en)
BR (1) BR7607564A (en)
CH (1) CH626999A5 (en)
DE (1) DE2551208C3 (en)
DK (1) DK146138C (en)
ES (1) ES453136A1 (en)
FR (1) FR2331352A1 (en)
GB (1) GB1563839A (en)
IE (1) IE44471B1 (en)
IT (1) IT1063992B (en)
LU (1) LU76194A1 (en)
MX (1) MX3937E (en)
NL (1) NL189133C (en)
SE (1) SE431800B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302355A (en) * 1977-08-01 1981-11-24 Warner-Lambert Company Platelet reference control
DE2828820A1 (en) * 1977-08-01 1979-02-08 Warner Lambert Co METHOD OF MANUFACTURING STABLE PLATE SUSPENSION AND STABLE PLATE SUSPENSION OBTAINED BY THE METHOD
JPS5917388B2 (en) * 1979-02-22 1984-04-20 富士レビオ株式会社 Absorbent for indirect flocculation reaction
EP0039195B1 (en) * 1980-04-28 1986-06-18 Montefiore Hospital and Medical Center Antibody detection process
GB2138132B (en) * 1983-04-12 1987-02-18 Robin Royston Amos Coombs Storage-stable antibody-linked erythrocytes
JPS6161055A (en) * 1984-08-31 1986-03-28 Shionogi & Co Ltd Preservative liquid of fixed red blood cells of aves for virus hemagglutination test
DE3501496A1 (en) * 1985-01-18 1986-07-24 Behringwerke Ag, 3550 Marburg METHOD FOR DETERMINING THE ACTIVITY OF THE COMPLEMENT SYSTEM OF THE BLOOD
FR2617185B1 (en) * 1987-06-25 1990-03-09 Fondation Nale Transfusion San METHOD FOR STABILIZING CELL MEMBRANES AND ITS APPLICATION TO THE PRESERVATION OF CELLS IN A FORM PROTECTING THE ESSENTIALS OF THEIR SURFACE ANTIGENS
US5079173A (en) * 1987-08-19 1992-01-07 Shionogi & Co., Ltd. Methods, hybridomas, monoclonal antibodies and sensitized cells for measuring hbs antigen
JPH01107154A (en) * 1987-10-20 1989-04-25 Seitetsu Kagaku Co Ltd Processed red blood-corpuscle and its manufacturing method
IL90188A0 (en) * 1988-05-18 1989-12-15 Cryopharm Corp Process and medium for the lyophilization of erythrocytes
US5045446A (en) * 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
EP0356258A3 (en) * 1988-08-26 1990-06-06 Cryopharm Corporation Processes for the lyophilization of red blood cells, together with media for lyophilization
US5059518A (en) * 1988-10-20 1991-10-22 Coulter Corporation Stabilized lyophilized mammalian cells and method of making same
US5882649A (en) * 1990-04-24 1999-03-16 Flustat Pty. Ltd. Oral vaccine comprising antigen surface-associated with red blood cells
DE69128782T2 (en) * 1990-04-24 1998-09-10 Flustat Pty Ltd ORAL ANTIQUE CONTAINING VACCINE TIED TO THE SURFACE OF ERYTHROCYTES
EP0721104A2 (en) * 1993-07-05 1996-07-10 Northern General Hospital N.H.S. Trust Preparation and stabilisation of cells
DE708649T1 (en) * 1993-07-05 2001-09-20 North Gen Hospital Nhs Trust PREPARATION AND STABILIZATION OF CELLS
CN1149338A (en) * 1994-04-05 1997-05-07 北方总医院N·H·S·托拉斯 Preparation and stabilisation of cell suspensions
GB2313288B (en) * 1996-05-24 2000-07-12 North Gen Hospital Nhs Trust Specimen collection fluid
CN100376669C (en) 2005-02-25 2008-03-26 深圳迈瑞生物医疗电子股份有限公司 Treatment method for biological erythrocyte volume long time stabilization
CN111295094A (en) 2017-10-09 2020-06-16 泰尔茂比司特生物技术有限公司 Freeze-drying container and method for using freeze-drying container
WO2019190787A1 (en) * 2018-03-27 2019-10-03 Exact Sciences Corporation Method for stabilizing hemoglobin and reagents for performing the same
JP2022525742A (en) 2019-03-14 2022-05-19 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー Freeze-drying loading tray assembly and system
FR3121577B1 (en) 2021-04-12 2024-03-08 Elitech Microbio Stabilizing composition, process using said composition for the manufacture of control products for analyzes of biological samples in mammals, and control products resulting from the implementation of said process
CN115399314B (en) * 2022-11-01 2023-05-19 天津德祥生物技术股份有限公司 Human ABO blood type inverse typing red blood cell capable of being freeze-dried and stored and storage method

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1521350A (en) * 1965-09-10 1968-04-19 Princeton Lab Mononucleosis detection
GB1244344A (en) * 1967-11-13 1971-08-25 Abbott Lab Hemagglutination testing procedure employing stabilized and potentiated erythrocytes and a method for their preparation
DE2025718C3 (en) * 1967-11-13 1979-06-13 Abbott Laboratories, Chicago, Ill. (V.St.A.) Method for stabilizing lyophilized erythrocytes
FR2233024A1 (en) * 1973-06-15 1975-01-10 Greyward Lab Interconti Treponema haemagglutination test - using tanned avian erythrocytes as carrier for ireponema antigen

Also Published As

Publication number Publication date
NL7612439A (en) 1977-05-17
IE44471B1 (en) 1981-12-16
DK146138B (en) 1983-07-04
DE2551208B2 (en) 1980-09-11
DK146138C (en) 1983-11-28
AR213420A1 (en) 1979-01-31
JPS5261218A (en) 1977-05-20
NL189133B (en) 1992-08-17
FR2331352A1 (en) 1977-06-10
IT1063992B (en) 1985-02-18
ATA843476A (en) 1979-10-15
FR2331352B1 (en) 1982-07-09
GB1563839A (en) 1980-04-02
JPS616941B2 (en) 1986-03-03
AU1958876A (en) 1978-05-18
AT356812B (en) 1980-05-27
BE848377A (en) 1977-05-16
AU511427B2 (en) 1980-08-21
IE44471L (en) 1977-05-14
MX3937E (en) 1981-10-02
SE431800B (en) 1984-02-27
NL189133C (en) 1993-01-18
BR7607564A (en) 1977-09-27
LU76194A1 (en) 1977-06-06
SE7612622L (en) 1977-05-15
DK510976A (en) 1977-05-15
CH626999A5 (en) 1981-12-15
DE2551208A1 (en) 1977-05-26
DE2551208C3 (en) 1981-05-27

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103