ES450550A1 - Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.

Info

Publication number
ES450550A1
ES450550A1 ES450550A ES450550A ES450550A1 ES 450550 A1 ES450550 A1 ES 450550A1 ES 450550 A ES450550 A ES 450550A ES 450550 A ES450550 A ES 450550A ES 450550 A1 ES450550 A1 ES 450550A1
Authority
ES
Spain
Prior art keywords
formula
group
alkyl
hydrogen atom
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES450550A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES450550A1 publication Critical patent/ES450550A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
ES450550A 1975-08-09 1976-08-06 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina. Expired ES450550A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB33283/75A GB1504424A (en) 1975-08-09 1975-08-09 Isoquinoline-derived aminoethers

Publications (1)

Publication Number Publication Date
ES450550A1 true ES450550A1 (es) 1977-12-16

Family

ID=10350917

Family Applications (6)

Application Number Title Priority Date Filing Date
ES450550A Expired ES450550A1 (es) 1975-08-09 1976-08-06 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462059A Expired ES462059A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES77462062A Expired ES462062A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462060A Expired ES462060A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462061A Expired ES462061A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462058A Expired ES462058A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES462059A Expired ES462059A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES77462062A Expired ES462062A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462060A Expired ES462060A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462061A Expired ES462061A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462058A Expired ES462058A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.

Country Status (19)

Country Link
US (1) US4113869A (en:Method)
JP (1) JPS5223083A (en:Method)
AT (2) AT354448B (en:Method)
AU (1) AU498422B2 (en:Method)
BE (1) BE844783A (en:Method)
CA (1) CA1076119A (en:Method)
CH (2) CH622780A5 (en:Method)
DE (1) DE2635276A1 (en:Method)
DK (1) DK357976A (en:Method)
ES (6) ES450550A1 (en:Method)
FR (1) FR2320755A1 (en:Method)
GB (1) GB1504424A (en:Method)
HU (1) HU173560B (en:Method)
IE (1) IE43506B1 (en:Method)
IL (1) IL50176A (en:Method)
NL (1) NL7608856A (en:Method)
NZ (1) NZ181619A (en:Method)
SE (1) SE7608641L (en:Method)
ZA (1) ZA764555B (en:Method)

Families Citing this family (38)

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DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
US4340600A (en) 1980-05-22 1982-07-20 Smithkline Corporation Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines
US4766131A (en) * 1980-10-17 1988-08-23 Pennwalt Corporation 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics
US4477670A (en) * 1981-02-19 1984-10-16 Hoechst-Roussel Pharmaceuticals Inc. 4-Aryloxy-1,2,3,4-tetrahydroisoquinolines
US4551474A (en) * 1981-02-19 1985-11-05 Hoechst-Roussel Pharmaceuticals Incorporated Methods of alleviating convulsions and pain employing 4-aryloxy-1,2,3,4 tetrahydroisoquinolines
US4375471A (en) * 1981-02-19 1983-03-01 Hoechst-Roussel Pharmaceuticals Inc. 4-Aryloxy-1,2,3,4-tetrahydroisoquinolines
US6562837B1 (en) * 1998-10-21 2003-05-13 Korea Institute Of Science & Technology Use of tetrahydroisoquinoline compounds for the treatment of septicemia
CA2389300C (en) * 1999-11-03 2010-06-08 Albany Molecular Research, Inc. 4-phenyl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
KR100885986B1 (ko) * 1999-11-03 2009-03-03 에이엠알 테크놀로지, 인크. 노르에피네프린, 도파민 및 세로토닌의 재흡수를 방지하기위한 아릴 및 헤테로아릴 치환된테트라하이드로이소퀴놀린 및 이들의 용도
EP1113007A1 (en) * 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists
BR0112350A (pt) 2000-07-11 2003-06-24 Albany Molecular Res Inc Composto, composição farmacêutica, e, método de tratar um animal afligido por um distúrbio neurológico ou psicológico
US7314937B2 (en) * 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
AU2005274927B2 (en) * 2004-07-15 2011-11-03 Albany Molecular Research, Inc. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US20060111393A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US20060111385A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
US20060111394A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
DE602005026169D1 (de) * 2004-12-17 2011-03-10 Janssen Pharmaceutica Nv Tetrahydroisochinolinverbindungen zur behandlung von zns-erkrankungen
PT1899334E (pt) 2005-06-17 2008-11-06 Janssen Pharmaceutica Nv Compostos de naftiridina
CN101243082A (zh) * 2005-06-17 2008-08-13 詹森药业有限公司 治疗cns障碍的六氢-吡咯并-异喹啉化合物
JP5258561B2 (ja) * 2005-07-15 2013-08-07 アルバニー モレキュラー リサーチ, インコーポレイテッド アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
US7846930B2 (en) * 2007-05-18 2010-12-07 Janssen Pharmaceutica Nv Diaryl-substituted tetrahydroisoquinolines as histamine H3 receptor and serotonin transporter modulators
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) * 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
BRPI0923225A2 (pt) 2008-12-02 2016-10-04 Chiralgen Ltd metodo para sintese de acidos nucleicos modificados no atomo de fosforo
AU2010247763B2 (en) 2009-05-12 2015-12-24 Albany Molecular Research, Inc. 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
CN102458123A (zh) * 2009-05-12 2012-05-16 阿尔巴尼分子研究公司 芳基、杂芳基和杂环取代的四氢异喹啉及其用途
KR20120023072A (ko) 2009-05-12 2012-03-12 브리스톨-마이어스 스큅 컴퍼니 (S)-7-(〔1,2,4〕트리아졸〔1,5-a〕피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린의 결정형 및 이의 용도
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
EP2620428B1 (en) * 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
CN104684923B (zh) 2012-07-13 2018-09-28 株式会社新日本科学 手性核酸佐剂
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
RU2015104762A (ru) 2012-07-13 2018-08-31 Уэйв Лайф Сайенсес Лтд. Хиральный контроль
WO2015108046A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
US10149905B2 (en) 2014-01-15 2018-12-11 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
EP3095461A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
CA2936712A1 (en) 2014-01-16 2015-07-23 Meena Chiral design

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Publication number Priority date Publication date Assignee Title
GB1058822A (en) * 1963-07-30 1967-02-15 Ici Ltd 3-amino-2-hydroxypropoxy heterocyclic derivatives
US3479358A (en) * 1966-09-19 1969-11-18 Warner Lambert Pharmaceutical Hexahydro-9,4a - iminoethano-4a-h-xanthenes and process for their production
US3666763A (en) * 1970-01-06 1972-05-30 Hoffmann La Roche 4-phenyl isoquinolines and process for preparing same
US3947456A (en) * 1970-01-06 1976-03-30 Hoffman-La Roche Inc. Substituted 4-phenyl isoquinolines
US3878215A (en) * 1971-12-01 1975-04-15 Sandoz Ag 2-Alkyl-3-substituted-4-aryl isoquinolines
US3910924A (en) * 1972-04-13 1975-10-07 Otsuka Pharma Co Ltd 3,4-Dihydrocarbostyril derivatives and a process for preparing the same
US3855227A (en) * 1972-05-08 1974-12-17 C Hollander ({31 )-di-o-isopropylidene-2-keto-l-gulonates
JPS5239035B2 (en:Method) * 1972-12-14 1977-10-03
US3872125A (en) * 1973-03-03 1975-03-18 Sandoz Ag 3-substituted-4-aryl isoquinolines
US3870722A (en) * 1973-11-02 1975-03-11 Sandoz Ag 2-Methyl-3-substituted-4-aryl isoquinolines
AR206061A1 (es) * 1974-11-15 1976-06-23 Knoll Ag Procedimiento para la produccion de nuevas 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7-, 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-isoquinolinas de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-6-metoxi-isoquinolinas y de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-7-metoxi-isoquinolinas eventualmente metiladas en la posicion 1

Also Published As

Publication number Publication date
AT354448B (de) 1979-01-10
IE43506L (en) 1977-02-09
IE43506B1 (en) 1981-03-11
FR2320755A1 (fr) 1977-03-11
SE7608641L (sv) 1977-02-10
IL50176A (en) 1979-10-31
ES462058A1 (es) 1978-06-16
JPS5223083A (en) 1977-02-21
FR2320755B1 (en:Method) 1979-09-14
ATA586876A (de) 1979-06-15
HU173560B (hu) 1979-06-28
CH622780A5 (en:Method) 1981-04-30
DE2635276A1 (de) 1977-02-17
BE844783A (fr) 1977-01-31
AU498422B2 (en) 1979-03-15
DK357976A (da) 1977-02-10
ES462061A1 (es) 1978-06-16
ES462059A1 (es) 1978-06-16
CH626611A5 (en:Method) 1981-11-30
NL7608856A (nl) 1977-02-11
ZA764555B (en) 1977-07-27
IL50176A0 (en) 1976-09-30
AT353793B (de) 1979-12-10
US4113869A (en) 1978-09-12
ES462060A1 (es) 1978-06-16
ES462062A1 (es) 1978-06-16
CA1076119A (en) 1980-04-22
GB1504424A (en) 1978-03-22
AU1670276A (en) 1978-02-16
ATA717378A (de) 1979-05-15
NZ181619A (en) 1979-08-31

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