ES449747A1 - Process for obtaining crystalline aesein - Google Patents
Process for obtaining crystalline aeseinInfo
- Publication number
- ES449747A1 ES449747A1 ES449747A ES449747A ES449747A1 ES 449747 A1 ES449747 A1 ES 449747A1 ES 449747 A ES449747 A ES 449747A ES 449747 A ES449747 A ES 449747A ES 449747 A1 ES449747 A1 ES 449747A1
- Authority
- ES
- Spain
- Prior art keywords
- seeds
- crystalline
- water
- cation exchanger
- eluate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 241000157280 Aesculus hippocastanum Species 0.000 abstract 2
- 150000001768 cations Chemical class 0.000 abstract 2
- 235000010181 horse chestnut Nutrition 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 229940011399 escin Drugs 0.000 abstract 1
- 229930186222 escin Natural products 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
Abstract
Procedure for the obtaining of crystalline escin from the seeds of aesculus hippocastanum, characterized by extracting shredded seeds of aesculus hippocastanum with organic solvents miscible with water, mainly alcohols, putting the extraction liquids obtained in contact with a cation exchanger in h form, the resulting eluate is concentrated by distillation, after removing the cation exchanger, treating the eluate with water, separating by filtration or centrifugation the crystalline precipitate originated and eventually converting the obtained scinic acid, with a pharmacologically compatible base, into the corresponding salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2530941A DE2530941C2 (en) | 1975-07-11 | 1975-07-11 | Process for the production of crystalline aescin and for the production of certain aescin salts as well as triethanolammonium aescinate and medicaments containing this salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES449747A1 true ES449747A1 (en) | 1977-08-16 |
Family
ID=5951217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES449747A Expired ES449747A1 (en) | 1975-07-11 | 1976-07-10 | Process for obtaining crystalline aesein |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5234913A (en) |
| AR (1) | AR210498A1 (en) |
| AU (1) | AU510202B2 (en) |
| BE (1) | BE844052A (en) |
| BG (1) | BG27378A3 (en) |
| CA (1) | CA1049497A (en) |
| CS (1) | CS193077B2 (en) |
| DE (1) | DE2530941C2 (en) |
| ES (1) | ES449747A1 (en) |
| FI (1) | FI63418C (en) |
| FR (1) | FR2316962A1 (en) |
| GB (1) | GB1551387A (en) |
| HK (1) | HK33781A (en) |
| HU (1) | HU175394B (en) |
| PH (1) | PH13088A (en) |
| PL (1) | PL99027B1 (en) |
| PT (1) | PT65301B (en) |
| RO (1) | RO71026A (en) |
| SU (1) | SU786856A3 (en) |
| YU (1) | YU39215B (en) |
| ZA (1) | ZA764064B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1487847B1 (en) * | 2002-03-25 | 2006-08-16 | Council of Scientific and Industrial Research | A simple process for obtaining beta-aescin from indian horse chestnut (aesculus indica) |
| RU2290189C1 (en) * | 2005-06-17 | 2006-12-27 | Игорь Юрьевич Макаров | Agent possessing with vein-tonic, anti-inflammatory and capillary-protective effect and method for its preparing |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1095989B (en) * | 1959-03-11 | 1960-12-29 | Madaus & Co Dr | Process for obtaining a crystallized acidic saponin from the seeds of the horse chestnut |
| FR1267224A (en) * | 1960-06-07 | 1961-07-21 | Madaus & Co Dr | Process for the preparation of crystallized acid saponin from horse chestnuts |
| DE1667884B2 (en) * | 1968-01-20 | 1976-09-30 | Knoll Ag, Chemische Fabriken, 6700 Ludwigshafen | PROCESS FOR THE EXTRACTION OF PURE AESCINE |
| DE2118916A1 (en) * | 1971-04-19 | 1972-11-09 | Schwabe, Willmar, Dr., 7500 Karlsruhe-Durlach | Water-soluble acid saponin mixts prodn - by extraction of horse-chestnuts and complex formation with (alkyl)benzene |
| YU37063B (en) * | 1971-12-06 | 1984-08-31 | Lek Tovarna Farmacevtskih | Process for preparing x-ray amorphous water-sulubleascin |
-
1975
- 1975-07-11 DE DE2530941A patent/DE2530941C2/en not_active Expired - Lifetime
-
1976
- 1976-06-23 AR AR263714A patent/AR210498A1/en active
- 1976-06-30 PT PT65301A patent/PT65301B/en unknown
- 1976-07-05 BG BG033672A patent/BG27378A3/en unknown
- 1976-07-05 FI FI761957A patent/FI63418C/en not_active IP Right Cessation
- 1976-07-07 SU SU762377644A patent/SU786856A3/en active
- 1976-07-07 GB GB28232/76A patent/GB1551387A/en not_active Expired
- 1976-07-08 YU YU01669/76A patent/YU39215B/en unknown
- 1976-07-08 AU AU15730/76A patent/AU510202B2/en not_active Expired
- 1976-07-08 ZA ZA764064A patent/ZA764064B/en unknown
- 1976-07-09 HU HU76MA2796A patent/HU175394B/en not_active IP Right Cessation
- 1976-07-09 CA CA256,649A patent/CA1049497A/en not_active Expired
- 1976-07-09 CS CS764568A patent/CS193077B2/en unknown
- 1976-07-10 ES ES449747A patent/ES449747A1/en not_active Expired
- 1976-07-10 RO RO7686933A patent/RO71026A/en unknown
- 1976-07-10 PL PL1976191113A patent/PL99027B1/en unknown
- 1976-07-12 JP JP51082845A patent/JPS5234913A/en active Granted
- 1976-07-12 BE BE168848A patent/BE844052A/en not_active IP Right Cessation
- 1976-07-12 PH PH18679A patent/PH13088A/en unknown
- 1976-07-12 FR FR7621314A patent/FR2316962A1/en active Granted
-
1981
- 1981-07-16 HK HK337/81A patent/HK33781A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA764064B (en) | 1977-07-27 |
| FI63418C (en) | 1983-06-10 |
| RO71026A (en) | 1981-09-24 |
| HU175394B (en) | 1980-07-28 |
| BG27378A3 (en) | 1979-10-12 |
| CS193077B2 (en) | 1979-09-17 |
| JPS5539560B2 (en) | 1980-10-13 |
| FR2316962B1 (en) | 1979-03-02 |
| HK33781A (en) | 1981-07-24 |
| PH13088A (en) | 1979-11-23 |
| PT65301A (en) | 1976-07-01 |
| AU1573076A (en) | 1978-01-12 |
| PT65301B (en) | 1977-12-13 |
| FR2316962A1 (en) | 1977-02-04 |
| AU510202B2 (en) | 1980-06-12 |
| AR210498A1 (en) | 1977-08-15 |
| YU39215B (en) | 1984-08-31 |
| FI761957A7 (en) | 1977-01-12 |
| JPS5234913A (en) | 1977-03-17 |
| CA1049497A (en) | 1979-02-27 |
| DE2530941C2 (en) | 1991-10-10 |
| YU166976A (en) | 1982-08-31 |
| SU786856A3 (en) | 1980-12-07 |
| PL99027B1 (en) | 1978-06-30 |
| DE2530941A1 (en) | 1977-01-27 |
| FI63418B (en) | 1983-02-28 |
| BE844052A (en) | 1977-01-12 |
| GB1551387A (en) | 1979-08-30 |
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