ES443825A1 - Procedimiento para la preparacion de d-homoroceto-pregna- nos. - Google Patents
Procedimiento para la preparacion de d-homoroceto-pregna- nos.Info
- Publication number
- ES443825A1 ES443825A1 ES443825A ES443825A ES443825A1 ES 443825 A1 ES443825 A1 ES 443825A1 ES 443825 A ES443825 A ES 443825A ES 443825 A ES443825 A ES 443825A ES 443825 A1 ES443825 A1 ES 443825A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- ketopregnanes
- homo
- image
- narcosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 206010002091 Anaesthesia Diseases 0.000 title 1
- 208000010513 Stupor Diseases 0.000 title 1
- 230000037005 anaesthesia Effects 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- -1 azido, mercapto, thiocyano Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742461312 DE2461312A1 (de) | 1974-12-23 | 1974-12-23 | D-homo-20-keto-pregnane und verfahren zu ihrer herstellung |
| DE19752506688 DE2506688A1 (de) | 1975-02-14 | 1975-02-14 | D-homo-19-nor-20-ketopregnane und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES443825A1 true ES443825A1 (es) | 1977-05-01 |
Family
ID=25768157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES443825A Expired ES443825A1 (es) | 1974-12-23 | 1975-12-23 | Procedimiento para la preparacion de d-homoroceto-pregna- nos. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4056633A (enExample) |
| JP (1) | JPS5188953A (enExample) |
| AU (1) | AU501685B2 (enExample) |
| CA (1) | CA1051868A (enExample) |
| DD (1) | DD123329A5 (enExample) |
| DK (1) | DK138501C (enExample) |
| ES (1) | ES443825A1 (enExample) |
| FR (1) | FR2295739A1 (enExample) |
| GB (1) | GB1538869A (enExample) |
| IL (1) | IL48628A0 (enExample) |
| LU (1) | LU74087A1 (enExample) |
| NL (1) | NL7514976A (enExample) |
| SE (1) | SE7514514L (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4104306A (en) * | 1976-05-05 | 1978-08-01 | Abbott Laboratories | 12A-Deoxy chelocardin |
| US5439900A (en) * | 1993-02-25 | 1995-08-08 | Bukusoglu; Cuneyt | Methods and compositions for providing analgesia and enhanced anesthesia |
| ATE339437T1 (de) * | 2002-08-16 | 2006-10-15 | Pharmacia & Upjohn Co Llc | 5-androsten-3-olsteroidzwischenprodukte und verfahren zu deren herstellung |
| US20070066579A1 (en) * | 2002-08-16 | 2007-03-22 | White Michael J | 5-androsten-3beta-ol steroid intermediates and processs for their preparation |
| TR201901745T4 (tr) | 2013-04-17 | 2019-03-21 | Sage Therapeutics Inc | 19-nor C3,3-disübstitüe edilmiş C21- n-pirazolil steroidleri ve bunların kullanım yöntemleri. |
| WO2014169836A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
| EP2986624B1 (en) | 2013-04-17 | 2020-03-25 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids for methods of treatment |
| US9725481B2 (en) | 2013-04-17 | 2017-08-08 | Sage Therapeutics, Inc. | 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof |
| RU2754534C2 (ru) | 2013-07-19 | 2021-09-03 | Сейдж Терапьютикс, Инк. | Нейроактивные стероиды, композиции и их использование |
| CA3235088A1 (en) | 2013-08-23 | 2015-02-26 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| US10246482B2 (en) | 2014-06-18 | 2019-04-02 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| TW202426002A (zh) | 2014-10-16 | 2024-07-01 | 美商賽吉醫療公司 | 用於治療中樞神經系統(cns)病症之組合物及方法 |
| EP3753927B1 (en) | 2014-10-16 | 2023-07-19 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| LT3224269T (lt) | 2014-11-27 | 2020-07-10 | Sage Therapeutics, Inc. | Kompozicijos ir būdai, skirti cns sutrikimams gydyti |
| HUE054092T2 (hu) | 2015-01-26 | 2021-08-30 | Sage Therapeutics Inc | Központi idegrendszeri zavarok kezelésére szolgáló kompozíciók és eljárások |
| WO2016134301A2 (en) | 2015-02-20 | 2016-08-25 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| DK3481845T3 (da) | 2016-07-11 | 2023-11-27 | Sage Therapeutics Inc | C17, c20 og c21 substituerede neuroaktive steroider og deres anvendelsesmetoder |
| WO2018013615A1 (en) | 2016-07-11 | 2018-01-18 | Sage Therapeutics, Inc. | C7, c12, and c16 substituted neuroactive steroids and their methods of use |
| AU2018392093B2 (en) * | 2017-12-22 | 2024-02-01 | Sage Therapeutics, Inc. | Compositions and methods for treating CNS disorders |
| JP7538040B2 (ja) * | 2018-01-12 | 2024-08-21 | セージ セラピューティクス， インコーポレイテッド | ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物 |
| JP7539378B2 (ja) | 2018-12-05 | 2024-08-23 | セージ セラピューティクス， インコーポレイテッド | 神経刺激性ステロイド及びその使用方法 |
| BR112021013393A2 (pt) * | 2019-01-08 | 2021-09-14 | Chengdu Kanghong Pharmaceutical Co, Ltd. | Composto de esteroide e uso do mesmo e método de preparação para o mesmo |
| CN114206900A (zh) | 2019-05-31 | 2022-03-18 | 萨奇治疗股份有限公司 | 神经活性类固醇及其组合物 |
| EP3990468A1 (en) * | 2019-06-27 | 2022-05-04 | Sage Therapeutics, Inc. | Compounds for treating cns disorders |
| EP3990467A1 (en) * | 2019-06-27 | 2022-05-04 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3876705A (en) * | 1972-06-12 | 1975-04-08 | Univ New Brunswick | Steroid total synthesis and intermediates |
-
1975
- 1975-12-09 IL IL48628A patent/IL48628A0/xx unknown
- 1975-12-17 AU AU87637/75A patent/AU501685B2/en not_active Expired
- 1975-12-17 US US05/641,602 patent/US4056633A/en not_active Expired - Lifetime
- 1975-12-19 DD DD190370A patent/DD123329A5/xx unknown
- 1975-12-22 SE SE7514514A patent/SE7514514L/xx unknown
- 1975-12-22 GB GB52351/75A patent/GB1538869A/en not_active Expired
- 1975-12-22 LU LU74087A patent/LU74087A1/xx unknown
- 1975-12-23 DK DK588775A patent/DK138501C/da active
- 1975-12-23 ES ES443825A patent/ES443825A1/es not_active Expired
- 1975-12-23 FR FR7539458A patent/FR2295739A1/fr not_active Withdrawn
- 1975-12-23 CA CA242,439A patent/CA1051868A/en not_active Expired
- 1975-12-23 JP JP50153888A patent/JPS5188953A/ja active Pending
- 1975-12-23 NL NL7514976A patent/NL7514976A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK138501C (da) | 1979-02-19 |
| FR2295739A1 (fr) | 1976-07-23 |
| DK588775A (da) | 1976-06-24 |
| GB1538869A (en) | 1979-01-24 |
| US4056633A (en) | 1977-11-01 |
| LU74087A1 (enExample) | 1976-07-20 |
| JPS5188953A (en) | 1976-08-04 |
| NL7514976A (nl) | 1976-06-25 |
| DD123329A5 (enExample) | 1976-12-12 |
| CA1051868A (en) | 1979-04-03 |
| AU8763775A (en) | 1977-06-23 |
| IL48628A0 (en) | 1976-02-29 |
| AU501685B2 (en) | 1979-06-28 |
| DK138501B (da) | 1978-09-18 |
| SE7514514L (sv) | 1976-06-24 |
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