ES443790A1 - Benzylpyrimidine derivatives - Google Patents
Benzylpyrimidine derivativesInfo
- Publication number
- ES443790A1 ES443790A1 ES443790A ES443790A ES443790A1 ES 443790 A1 ES443790 A1 ES 443790A1 ES 443790 A ES443790 A ES 443790A ES 443790 A ES443790 A ES 443790A ES 443790 A1 ES443790 A1 ES 443790A1
- Authority
- ES
- Spain
- Prior art keywords
- amino
- groups
- compounds
- pyrrolidino
- piperidino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Compounds of the formula < IMAGE > in which R<1> represents amino or -NHR<3> R<2> represents amino, pyrrolo, pyrrolidino, piperidino, -NHR<3> or -N(R<3>)2 R<3> represents C1-4-alkyl or C1-4-alkenyl and Z represents hydrogen, chlorine, bromine, pyrrolo, pyrrolidino, piperidino, morpholino, R<3>, OR<3> or -N(R<3>)2, are prepared by hydrolysis of corresponding compounds whose amino groups in the pyrimidine ring and/or whose substituents R<1> and R<2> are present in the form of groups which can be hydrolysed to amino and/or R<3>HN groups. The compounds are distinguished by antibacterial activity or a synergistic effect in combination with sulphonamides and good tolerability.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1728774A CH605828A5 (en) | 1974-12-24 | 1974-12-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES443790A1 true ES443790A1 (en) | 1977-12-16 |
Family
ID=4424233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES443790A Expired ES443790A1 (en) | 1974-12-24 | 1975-12-23 | Benzylpyrimidine derivatives |
Country Status (25)
Country | Link |
---|---|
JP (1) | JPS5191273A (en) |
AT (1) | AT344704B (en) |
AU (1) | AU500102B2 (en) |
BE (1) | BE836996A (en) |
BR (1) | BR7508534A (en) |
CA (1) | CA1059127A (en) |
CH (2) | CH605828A5 (en) |
CU (1) | CU34406A (en) |
DD (1) | DD123603A5 (en) |
DE (1) | DE2558150A1 (en) |
DK (1) | DK137797B (en) |
ES (1) | ES443790A1 (en) |
FI (1) | FI753312A (en) |
FR (1) | FR2295750A1 (en) |
GB (1) | GB1492140A (en) |
HU (1) | HU174324B (en) |
IL (1) | IL48416A (en) |
LU (1) | LU73971A1 (en) |
NL (1) | NL7514269A (en) |
NO (1) | NO141408C (en) |
PH (1) | PH12314A (en) |
PL (1) | PL101046B1 (en) |
SE (1) | SE417607B (en) |
SU (1) | SU612629A3 (en) |
ZA (1) | ZA756964B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR71725B (en) * | 1977-11-10 | 1983-06-22 | Hoffmann La Roche | |
AU2010284255B2 (en) * | 2009-08-17 | 2016-11-17 | Memorial Sloan-Kettering Cancer Center | Heat shock protein binding compounds, compositions, and methods for making and using same |
EA201692155A1 (en) | 2014-05-13 | 2017-04-28 | Мемориал Слоун-Кеттеринг Кэнсэ Сентр | Hsp70 modulators and methods for their production and use |
-
1974
- 1974-12-24 CH CH1728774A patent/CH605828A5/xx not_active IP Right Cessation
-
1975
- 1975-11-04 IL IL48416A patent/IL48416A/en unknown
- 1975-11-05 ZA ZA00756964A patent/ZA756964B/en unknown
- 1975-11-07 AU AU86433/75A patent/AU500102B2/en not_active Expired
- 1975-11-25 FI FI753312A patent/FI753312A/fi not_active Application Discontinuation
- 1975-11-29 CU CU7534406A patent/CU34406A/en unknown
- 1975-12-08 NL NL7514269A patent/NL7514269A/en not_active Application Discontinuation
- 1975-12-09 LU LU73971A patent/LU73971A1/xx unknown
- 1975-12-18 CA CA242,038A patent/CA1059127A/en not_active Expired
- 1975-12-19 HU HU75HO1864A patent/HU174324B/en unknown
- 1975-12-22 BR BR8534/75A patent/BR7508534A/en unknown
- 1975-12-22 AT AT975975A patent/AT344704B/en not_active IP Right Cessation
- 1975-12-22 SU SU752301512A patent/SU612629A3/en active
- 1975-12-22 JP JP50152026A patent/JPS5191273A/ja active Pending
- 1975-12-22 PH PH7517896A patent/PH12314A/en unknown
- 1975-12-22 FR FR7539341A patent/FR2295750A1/en active Granted
- 1975-12-23 SE SE7514642A patent/SE417607B/en unknown
- 1975-12-23 ES ES443790A patent/ES443790A1/en not_active Expired
- 1975-12-23 DE DE19752558150 patent/DE2558150A1/en not_active Ceased
- 1975-12-23 DK DK589675AA patent/DK137797B/en unknown
- 1975-12-23 DD DD190511A patent/DD123603A5/xx unknown
- 1975-12-23 GB GB52604/75A patent/GB1492140A/en not_active Expired
- 1975-12-23 PL PL1975185924A patent/PL101046B1/en unknown
- 1975-12-23 BE BE163041A patent/BE836996A/en unknown
- 1975-12-23 NO NO754372A patent/NO141408C/en unknown
-
1977
- 1977-12-07 CH CH1499977A patent/CH617191A5/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DD123603A5 (en) | 1977-01-05 |
DK589675A (en) | 1976-06-25 |
AT344704B (en) | 1978-08-10 |
SU612629A3 (en) | 1978-06-25 |
NL7514269A (en) | 1976-06-28 |
NO141408B (en) | 1979-11-26 |
DK137797C (en) | 1978-10-16 |
LU73971A1 (en) | 1977-07-01 |
DK137797B (en) | 1978-05-08 |
IL48416A0 (en) | 1976-01-30 |
ZA756964B (en) | 1976-10-27 |
FR2295750B1 (en) | 1980-06-20 |
IL48416A (en) | 1980-02-29 |
SE7514642L (en) | 1976-06-28 |
GB1492140A (en) | 1977-11-16 |
CA1059127A (en) | 1979-07-24 |
DE2558150A1 (en) | 1976-07-01 |
BR7508534A (en) | 1976-12-21 |
NO141408C (en) | 1980-03-05 |
FI753312A (en) | 1976-06-25 |
AU8643375A (en) | 1977-05-12 |
ATA975975A (en) | 1977-12-15 |
PH12314A (en) | 1979-01-16 |
CU34406A (en) | 1978-09-08 |
BE836996A (en) | 1976-06-23 |
CH617191A5 (en) | 1980-05-14 |
NO754372L (en) | 1976-06-25 |
SE417607B (en) | 1981-03-30 |
PL101046B1 (en) | 1978-11-30 |
FR2295750A1 (en) | 1976-07-23 |
AU500102B2 (en) | 1979-05-10 |
CH605828A5 (en) | 1978-10-13 |
JPS5191273A (en) | 1976-08-10 |
HU174324B (en) | 1979-12-28 |
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