ES441142A1 - 2-(2-thenyl)-1,4-dimethylpyridinium halides - Google Patents

2-(2-thenyl)-1,4-dimethylpyridinium halides

Info

Publication number
ES441142A1
ES441142A1 ES441142A ES441142A ES441142A1 ES 441142 A1 ES441142 A1 ES 441142A1 ES 441142 A ES441142 A ES 441142A ES 441142 A ES441142 A ES 441142A ES 441142 A1 ES441142 A1 ES 441142A1
Authority
ES
Spain
Prior art keywords
formula
dimethyl
dimethylpyridinium
thenyl
halides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES441142A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Made SA
Original Assignee
Laboratorios Made SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Made SA filed Critical Laboratorios Made SA
Priority to ES441142A priority Critical patent/ES441142A1/en
Priority to NZ181891A priority patent/NZ181891A/en
Priority to BE170278A priority patent/BE845756A/en
Priority to AT657776A priority patent/AT352299B/en
Priority to GB37473/76A priority patent/GB1553614A/en
Priority to AU17623/76A priority patent/AU502649B2/en
Priority to CH1161476A priority patent/CH615682A5/en
Priority to DE2641320A priority patent/DE2641320C3/en
Priority to SU762396747A priority patent/SU604494A3/en
Priority to PT65595A priority patent/PT65595B/en
Priority to CA261,490A priority patent/CA1066283A/en
Priority to JP51110937A priority patent/JPS5257193A/en
Priority to SE7610336A priority patent/SE7610336L/en
Priority to NL7610438A priority patent/NL7610438A/en
Priority to FR7628180A priority patent/FR2324302A1/en
Priority to AR264477A priority patent/AR214297A1/en
Priority to SU772474104A priority patent/SU633481A3/en
Priority to SU772473620A priority patent/SU626699A3/en
Priority to SU772472888A priority patent/SU625611A3/en
Priority to SU772472890A priority patent/SU637084A3/en
Priority to FR7717089A priority patent/FR2339608A1/en
Priority to FR7717091A priority patent/FR2339610A1/en
Priority to FR7717092A priority patent/FR2339611A1/en
Priority to FR7717090A priority patent/FR2339609A1/en
Publication of ES441142A1 publication Critical patent/ES441142A1/en
Priority to SE8000206A priority patent/SE8000206L/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

A process for obtaining 2,5-dimethyl-thieno [3,2-f] morphine of formula i ** (see formula) ** Characterized in that a mixture of 2- (2-tenyl) -1,4-dimethyl-1,2,3,6-tetrahydropyridine (V) is subjected to a cyclization reaction. ** (see formula) ** Y 2-(2-tenil)-1,4-dimetil-1,2,5,6-tetrahidropiridina (VI) ** (see formula) ** By heating to 135º c. In the presence of a strong mineral acid, whereby the 2,5-dimethyl-thieno [3,2-f] morphine of formula i is obtained. (Machine-translation by Google Translate, not legally binding)
ES441142A 1975-09-20 1975-09-20 2-(2-thenyl)-1,4-dimethylpyridinium halides Expired ES441142A1 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
ES441142A ES441142A1 (en) 1975-09-20 1975-09-20 2-(2-thenyl)-1,4-dimethylpyridinium halides
NZ181891A NZ181891A (en) 1975-09-20 1976-08-30 2,5-demethylthieno(3,2-f)morphan and precursors thereto
BE170278A BE845756A (en) 1975-09-20 1976-09-01 2,5-DIMETHYL-THIENO (3,2-F) MORPHANE, ITS PREPARATION PROCESS AND ITS APPLICATION
AT657776A AT352299B (en) 1975-09-20 1976-09-06 PROCESS FOR PRODUCING NEW 2,5-DIMETHYLTHIENO (3,2-F) -MORPHANE
GB37473/76A GB1553614A (en) 1975-09-20 1976-09-09 2-(2-thenyl)-1,4-dimethylpyridinium halides
AU17623/76A AU502649B2 (en) 1975-09-20 1976-09-10 2, 5-dimethyl-thieno(3, 2-f , 7 morphan and salts thereof
CH1161476A CH615682A5 (en) 1975-09-20 1976-09-13 Process for the preparation of a thienomorphane derivative
DE2641320A DE2641320C3 (en) 1975-09-20 1976-09-14 2,5-Dimethyl-thieno [3,2-f] -morphane Process for the production thereof and pharmaceutical preparations containing the same
SU762396747A SU604494A3 (en) 1975-09-20 1976-09-15 Method of preparing 2,5-dimethyl-thieno-(3,2-f) morphane
PT65595A PT65595B (en) 1975-09-20 1976-09-15 PROCEDURE FOR THE PREPARATION OF 2,5-DIMETIL-TIENO / 3,2-F / MORFANO
CA261,490A CA1066283A (en) 1975-09-20 1976-09-17 2,5-dimethyl-thieno-(3,2-f)-morphan and intermediates
JP51110937A JPS5257193A (en) 1975-09-20 1976-09-17 Novel 2*55dimethyllthienoo *3*22f**morphan and intermediate products thereof during droducing same and production method
SE7610336A SE7610336L (en) 1975-09-20 1976-09-17 ANALOGICAL PROCEDURE FOR THE PREPARATION OF 2,5-DIMETHYL-TIENO (3,2-F) MORPHANE AND ACID ADDITIONAL SALTS THEREOF
NL7610438A NL7610438A (en) 1975-09-20 1976-09-20 NEW GROUP OF CONNECTIONS WITH ANALGETICAL EFFECT.
FR7628180A FR2324302A1 (en) 1975-09-20 1976-09-20 2,5-DIMETHYL-THIENO (3,2-F) MORPHANE, ITS PREPARATION PROCESS AND ITS APPLICATION
AR264477A AR214297A1 (en) 1975-09-20 1976-11-27 A PROCEDURE FOR THE OBTAINING OF 2,5-DIMETHYL-HAVE (3,2-F) MORPHANE
SU772474104A SU633481A3 (en) 1975-09-20 1977-04-22 Method of obtaining 2-thienyl-(4-methyl-2-pyridyl) ketone
SU772473620A SU626699A3 (en) 1975-09-20 1977-04-22 Method of producing 2-(2-thienyl)-1,4-dimethylpyridin bromide
SU772472888A SU625611A3 (en) 1975-09-20 1977-04-22 Method of producing 2-(2-thienyl)-4-methylpyridine
SU772472890A SU637084A3 (en) 1975-09-20 1977-04-22 Method of obtaining 2-(2-thenyl)-1,4-dimethyl-1,2,3,6-tetra-hydropyridines
FR7717089A FR2339608A1 (en) 1975-09-20 1977-06-03 2-THIENYL- (4-METHYL-2-PYRIDYL) CETONE, ITS PREPARATION PROCESS AND ITS THERAPEUTIC APPLICATION
FR7717091A FR2339610A1 (en) 1975-09-20 1977-06-03 2- (2-THENYL) -1,4-DIMETHYL PYRIDINIUM BROMIDE ITS PREPARATION PROCESS AND ITS THERAPEUTIC APPLICATION
FR7717092A FR2339611A1 (en) 1975-09-20 1977-06-03 2- (2-THENYL) -1,4-DIMETHYL-1,2,3,6-TETRAHYDROPYRIDINE AND 2- (2-THENYL) -1,4-DIMETHYL-1,2,5,6-TETRAHYDROPYRIDINE, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR7717090A FR2339609A1 (en) 1975-09-20 1977-06-03 2- (2-THENYL) -4-METHYL PYRIDINE, ITS PREPARATION PROCESS AND ITS THERAPEUTIC APPLICATION
SE8000206A SE8000206L (en) 1975-09-20 1980-01-10 ANALOGICAL PROCEDURE FOR THE PREPARATION OF 2- (2-TENYL) -4-METHYL-PYRIDINE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES441142A ES441142A1 (en) 1975-09-20 1975-09-20 2-(2-thenyl)-1,4-dimethylpyridinium halides

Publications (1)

Publication Number Publication Date
ES441142A1 true ES441142A1 (en) 1977-07-01

Family

ID=8470020

Family Applications (1)

Application Number Title Priority Date Filing Date
ES441142A Expired ES441142A1 (en) 1975-09-20 1975-09-20 2-(2-thenyl)-1,4-dimethylpyridinium halides

Country Status (16)

Country Link
JP (1) JPS5257193A (en)
AR (1) AR214297A1 (en)
AT (1) AT352299B (en)
AU (1) AU502649B2 (en)
BE (1) BE845756A (en)
CA (1) CA1066283A (en)
CH (1) CH615682A5 (en)
DE (1) DE2641320C3 (en)
ES (1) ES441142A1 (en)
FR (5) FR2324302A1 (en)
GB (1) GB1553614A (en)
NL (1) NL7610438A (en)
NZ (1) NZ181891A (en)
PT (1) PT65595B (en)
SE (2) SE7610336L (en)
SU (5) SU604494A3 (en)

Also Published As

Publication number Publication date
AU502649B2 (en) 1979-08-02
GB1553614A (en) 1979-09-26
AR214297A1 (en) 1979-05-31
DE2641320A1 (en) 1977-03-24
FR2339610A1 (en) 1977-08-26
SU637084A3 (en) 1978-12-05
FR2324302B1 (en) 1978-12-15
AT352299B (en) 1979-09-10
BE845756A (en) 1977-03-01
DE2641320B2 (en) 1979-08-02
FR2339611A1 (en) 1977-08-26
SE8000206L (en) 1980-01-10
AU1762376A (en) 1978-03-16
FR2339609A1 (en) 1977-08-26
NZ181891A (en) 1979-01-11
SU625611A3 (en) 1978-09-25
ATA657776A (en) 1979-02-15
CA1066283A (en) 1979-11-13
FR2339608A1 (en) 1977-08-26
FR2324302A1 (en) 1977-04-15
NL7610438A (en) 1977-03-22
SU633481A3 (en) 1978-11-15
SU626699A3 (en) 1978-09-30
PT65595A (en) 1976-10-01
PT65595B (en) 1978-03-28
DE2641320C3 (en) 1980-04-03
SU604494A3 (en) 1978-04-25
JPS5257193A (en) 1977-05-11
CH615682A5 (en) 1980-02-15
SE7610336L (en) 1977-03-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971103