ES437424A1 - Procedure for the preparation of new derivatives of bifenilyl. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the preparation of new biphenyl derivatives of the general formula I, **(See formula)** in which a hydrogen, fluorine or bromine atom means, a methyl, methoxy, nitro, cyano group or also a chlorine atom, if they do not simultaneously represent A to the methylene group, R2 a hydrogen atom, R5 the carboxyl group, m to the number 2 and n the number 0 or also a methylthio group, in case m represents the number 1, R2 means a hydrogen or fluorine atom; R5 means a methyl, hydroxymethyl or carboxyl group, a carbalkoxy radical with 2 to 7 carbon atoms, optionally substituted with a methoxy group, or a carbalkenyloxy group with 3 to 7 carbon atoms, a carbalkoxy radical with 8 to 13 carbon atoms, a phenoxycarbonyl or pyridylmethoxycarbonyl group, a carbamido group optionally substituted with 1 or 2 lower alcohol radicals of 1 to 3 carbon atoms or with a phenyl group, or a morpholinocarbonyl, piperidinocarbonyl, thiomorpholinocarbonyl, (1-oxidothiomorpholine) -carbonyl group (1,1-dioxydothiomorpholino) -carbonyl, or also a hydrogen atom, if R1 and R2 do not simultaneously represent two hydrogen atoms, A the methylene group, n the number 0 and m the number 2; A means a methylene group optionally substituted with 1 or 2 lower alcohol radicals of 1 to 3 carbon atoms or with a hydroxymethyl group, or a hydroxymethylene or carbonyl group; n means the numbers 0, 1, 2 or 3; and m means the numbers 1 or 2, as well as its diastereoisomers, optically active antipodes and physiologically compatible salts with organic or inorganic bases, if it means the carboxyl group, characterized in that a thioether of general formula II is oxidized, **(See formula)** wherein R1, R2, R5, A, m and n are as defined at the beginning; and a compound of the general formula I, obtained according to the procedure, is cleaved, if desired, below into its optically active antipodes, and/or a compound obtained of the general formula I, in which R5 represents an ester radical is transformed, by hydrolysis into the corresponding carboxylic acid, and/or a compound obtained from the formula I, in which R5 represents the carboxyl group, is transformed into a physiologically compatible salt with an organic or inorganic base. (Machine-translation by Google Translate, not legally binding)