ES435697A1 - A method for the preparation of acid 3- (benzoil trisustituido) -propionico. (Machine-translation by Google Translate, not legally binding)
- Google Patents
A method for the preparation of acid 3- (benzoil trisustituido) -propionico. (Machine-translation by Google Translate, not legally binding)
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Takeda Pharmaceutical Co Ltd
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Takeda Chemical Industries Ltd
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Priority to ES435697ApriorityCriticalpatent/ES435697A1/en
Publication of ES435697A1publicationCriticalpatent/ES435697A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
A method for the preparation of 3- (trisubstituted benzoyl) -propionic acid the formula **(See formula)** wherein R1 is an alcohol group of 1 to 4 carbon atoms, an alkoxy group of 1 to 4 carbon atoms, or hydroxyl, and R2 and R3 are, the same or different from each other, an alcohol group of 1 to 4 carbon atoms, an alkoxy group of 1 to 4 carbon atoms, hydroxyl, halogen or an alcoholyl group of 1 to 4 carbon atoms, or are, in conjunction with each other, an alcoholylenedioxy group of 1 to 3 carbon atoms, provided that when R1 is the alkoxy group, at least one of R2 and R3 is the alkoxy group or the alcoholylthio group, or R2 and R3 are, in conjunction with each other, the alcoholylenedioxy; when R1 is the alcoholic or hydroxyl group, R2 and R3 are, the same or different, the alkoxy group, the alcoholylthio group or, in conjunction with each other, the alcoholylenedioxy; when R2 and R3 are methoxy, R1 is an alkoxy group of 2 to 4 carbon atoms or hydroxyl and when R2 is the alcohol and R3 is methoxy, R1 is an alkoxy group of 2 to 4 carbon atoms, which comprises treating with a acid or alkali a compound of formula **(See formula)** wherein R1, R2 and R3 have the same meaning as set out above and R4 and R5 are, the same or different from each other, an esterified or cyano carboxyl group, or one of R4 and R5 is hydrogen and the other is cyano. (Machine-translation by Google Translate, not legally binding)
ES435697A1975-03-171975-03-17A method for the preparation of acid 3- (benzoil trisustituido) -propionico. (Machine-translation by Google Translate, not legally binding)
ExpiredES435697A1
(en)
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