ES432863A1 - Method of producing 1-n-l- - alpha-hydroxy-ypsilon-aminobutyryl -xk-62-2 - Google Patents

Method of producing 1-n-l- - alpha-hydroxy-ypsilon-aminobutyryl -xk-62-2

Info

Publication number
ES432863A1
ES432863A1 ES432863A ES432863A ES432863A1 ES 432863 A1 ES432863 A1 ES 432863A1 ES 432863 A ES432863 A ES 432863A ES 432863 A ES432863 A ES 432863A ES 432863 A1 ES432863 A1 ES 432863A1
Authority
ES
Spain
Prior art keywords
formula
see formula
amino group
see
ypsilon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES432863A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of ES432863A1 publication Critical patent/ES432863A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A procedure for the production of a new antibiotic of the formula: **(See formula)** consisting of reacting a compound of the formula: **(See formula)** with an acylating agent or with an amino group protecting reagent to introduce a removable protecting group into the free amino group linked to the carbon atom at the 2'position; acylating the free amino group linked to the carbon atom at position 1 with an acylating agent represented by the formula: **(See formula)** where Y3 is H and Y4 is: **(See formula)** where R1, and R2 can be the same or different and H, OH, NO2, Cl, Br, I, alkyl groups of 1 to 5 carbon atoms or alkoxy groups of 1 to 5 carbon atoms and R4 is Cl, Br, or I and Z is **(See formula)** (see formula) Cl, Br, I or Oh and then remove said protecting groups. (Machine-translation by Google Translate, not legally binding)
ES432863A 1973-12-12 1974-12-12 Method of producing 1-n-l- - alpha-hydroxy-ypsilon-aminobutyryl -xk-62-2 Expired ES432863A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13782873A JPS5635194B2 (en) 1973-12-12 1973-12-12

Publications (1)

Publication Number Publication Date
ES432863A1 true ES432863A1 (en) 1976-11-01

Family

ID=15207784

Family Applications (1)

Application Number Title Priority Date Filing Date
ES432863A Expired ES432863A1 (en) 1973-12-12 1974-12-12 Method of producing 1-n-l- - alpha-hydroxy-ypsilon-aminobutyryl -xk-62-2

Country Status (14)

Country Link
JP (1) JPS5635194B2 (en)
AT (1) AT337360B (en)
CA (1) CA1030531A (en)
DE (1) DE2458920A1 (en)
DK (1) DK644274A (en)
ES (1) ES432863A1 (en)
FR (1) FR2254566B1 (en)
GB (1) GB1470330A (en)
IN (1) IN141069B (en)
NL (1) NL7416210A (en)
NO (1) NO139563C (en)
PH (1) PH14352A (en)
SE (1) SE417826B (en)
ZA (1) ZA747908B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX3676E (en) * 1975-07-15 1981-04-23 Abbott Lab PROCEDURE FOR OBTAINING DERIVATIVES FROM ANTIBIOTIC XK-62-2

Also Published As

Publication number Publication date
AU7636174A (en) 1976-06-17
GB1470330A (en) 1977-04-14
AT337360B (en) 1977-06-27
PH14352A (en) 1981-06-03
NL7416210A (en) 1975-06-16
SE7415610L (en) 1975-06-13
SE417826B (en) 1981-04-13
JPS5088051A (en) 1975-07-15
NO139563B (en) 1978-12-27
FR2254566B1 (en) 1979-08-10
IN141069B (en) 1977-01-15
DE2458920A1 (en) 1975-06-26
ZA747908B (en) 1976-01-28
NO744448L (en) 1975-07-07
FR2254566A1 (en) 1975-07-11
DK644274A (en) 1975-08-18
ATA991974A (en) 1976-10-15
JPS5635194B2 (en) 1981-08-15
CA1030531A (en) 1978-05-02
NO139563C (en) 1979-04-04

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