ES430903A1 - Process for preparing *11oxoo22phenyl halophenyu or thienyll22mehyll 6*77dichlorooindanyloxy*acetate - Google Patents

Process for preparing *11oxoo22phenyl halophenyu or thienyll22mehyll 6*77dichlorooindanyloxy*acetate

Info

Publication number
ES430903A1
ES430903A1 ES430903A ES430903A ES430903A1 ES 430903 A1 ES430903 A1 ES 430903A1 ES 430903 A ES430903 A ES 430903A ES 430903 A ES430903 A ES 430903A ES 430903 A1 ES430903 A1 ES 430903A1
Authority
ES
Spain
Prior art keywords
formula
compound
see formula
halophenyl
thienyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES430903A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES430903A1 publication Critical patent/ES430903A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A process for the preparation of the (1-oxo-2-phenyl, halophenyl or thienyl-2-methyl-6,7-dichloro-5-indanyloxy) acetic acid of the formula: **(See formula)** where R is lower alkyl or CH2CO2R'' and R'is phenyl, halophenyl or thienyl and R''is hydrogen or lower alkyl, the procedure of which consists of: (a) reacting a compound of formula **(See formula)** with a compound selected from the group consisting of **(See formula)** where X is halogen, and Z is hydrogen or R'under the Friedel-Crafts reaction conditions, to form a compound of formula **(See formula)** where R and Z are those defined above; (b) when Z is hydrogen, react the latter compound with YX, where Y is phenyl, halophenyl, thienyl, diphenylyodo, dihalofenilyodo or dithienilyodo and X is the one defined above, to form a compound of formula: **(See formula)** where R and R'are those defined above. (Machine-translation by Google Translate, not legally binding)
ES430903A 1974-07-30 1974-10-10 Process for preparing *11oxoo22phenyl halophenyu or thienyll22mehyll 6*77dichlorooindanyloxy*acetate Expired ES430903A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49265374A 1974-07-30 1974-07-30

Publications (1)

Publication Number Publication Date
ES430903A1 true ES430903A1 (en) 1977-01-16

Family

ID=23957086

Family Applications (1)

Application Number Title Priority Date Filing Date
ES430903A Expired ES430903A1 (en) 1974-07-30 1974-10-10 Process for preparing *11oxoo22phenyl halophenyu or thienyll22mehyll 6*77dichlorooindanyloxy*acetate

Country Status (11)

Country Link
JP (1) JPS51125058A (en)
AT (1) AT335444B (en)
CA (1) CA1038396A (en)
CH (1) CH613930A5 (en)
CS (1) CS190440B2 (en)
DD (1) DD114060A5 (en)
ES (1) ES430903A1 (en)
HU (1) HU170035B (en)
NL (1) NL7412828A (en)
PL (1) PL98291B1 (en)
YU (1) YU272574A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0618182B1 (en) * 1993-03-31 1996-12-18 Kagome Kabushiki Kaisha Indene derivatives and antimicrobial agents containing them

Also Published As

Publication number Publication date
NL7412828A (en) 1976-02-03
ATA808074A (en) 1976-07-15
CH613930A5 (en) 1979-10-31
JPS51125058A (en) 1976-11-01
PL98291B1 (en) 1978-04-29
YU272574A (en) 1982-06-30
AT335444B (en) 1977-03-10
CS190440B2 (en) 1979-05-31
CA1038396A (en) 1978-09-12
DD114060A5 (en) 1975-07-12
HU170035B (en) 1977-03-28

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