ES428107A1 - 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity - Google Patents

2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity

Info

Publication number
ES428107A1
ES428107A1 ES428107A ES428107A ES428107A1 ES 428107 A1 ES428107 A1 ES 428107A1 ES 428107 A ES428107 A ES 428107A ES 428107 A ES428107 A ES 428107A ES 428107 A1 ES428107 A1 ES 428107A1
Authority
ES
Spain
Prior art keywords
carbalkoxy
hydrogen
alkanoyl
aryl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES428107A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES428107A1 publication Critical patent/ES428107A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/52—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A procedure for the preparation of piperazinylquinoxaline compounds of the formula: ** (See formula) ** and its non-toxic and pharmaceutically acceptable salts, where the dotted line indicates the possibility of unsaturation 3,4, R1 is oxygen, R4 is oxygen, hydrogen, alkyl or aminoalkyl, m is 0 or 1, n is 0 or 1, R3 is hydrogen, alkyl, alkanoyl, aryl, substituted aryl, alkylthio, arylthio, alkoxy, amino, alkoxycarbonyl, alkylamino, dialkylamino, hydroxy, halogen, carboxy, keto, carbalkoxy, carbamoyl, l-alkylcarbamoyl or N, N-dialkylcarbamoyl or alkylimino., or R4 and R3 can be linked to form, together with the nitrogen and carbon atoms of the quinoxaline nucleus, a 5-7 membered ring, R5, R6, R7 and R8 are hydrogen, allyl, haloalkyl, haloalkylthio, arylalkyl, cycloalkyl, aroyl, carbalkoxy, alkyl, nitro, alkanoyl, aryl, substituted aryl, alkylthio, alkylsulfonyl, haloalkylsulfonyl, alkylsulfinyl, haloalkylsulfinyl, halo, amino, alkylamino, dialkylamino, hydroxy, halogen, carboxy, carbalkoxy, carbamoyl, N-alkylcarbamoyl, cyano, N, N-dialkylcarbamoyl-, dialkylsulfamoyl, or sulfamoyl, R4'is hydrogen, allyl, substituted allyl, haloalkyl, arylalkyl, arylalkoxycarbonyl, aryloxycarbonyl, cycloalkyl, alkanoyl, aroyl, carbalkoxy, alkoxycarbonyl, alkylidenaminoxycarbonyl, carbalkoxyalkylenedithiocarbonyl, alkyldithiocarbonyl, or -β R2', R3', R5'and R6' are each keto or two monovalent groups selected from the group consisting of hydrogen, alkyl, alkanoyl, aryl, substituted aryl, carboxy, carbalkoxy, carbamoyl, N-alkylcarbamoyl or N, N-dialkylcarbamoyl or R2'and R3' and/or R5'and R6' are attached, together with the carbon atoms to which they are attached, to form a cycloaliphatic substituent; whose procedure is to react a quinoxaline of structure: ** (See formula) ** where Y is a replaceable group, with a piperazine of structure (see formula) (Machine-translation by Google Translate, not legally binding)
ES428107A 1973-07-13 1974-07-09 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity Expired ES428107A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37902273A 1973-07-13 1973-07-13
US46538174A 1974-04-29 1974-04-29

Publications (1)

Publication Number Publication Date
ES428107A1 true ES428107A1 (en) 1976-11-16

Family

ID=27008442

Family Applications (1)

Application Number Title Priority Date Filing Date
ES428107A Expired ES428107A1 (en) 1973-07-13 1974-07-09 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity

Country Status (18)

Country Link
JP (1) JPS5037791A (en)
AU (1) AU7073174A (en)
BG (1) BG21606A3 (en)
CH (1) CH605919A5 (en)
DD (1) DD112127A5 (en)
DE (1) DE2433397A1 (en)
DK (1) DK342674A (en)
ES (1) ES428107A1 (en)
FI (1) FI193974A (en)
FR (1) FR2236499B1 (en)
GB (1) GB1440722A (en)
IE (1) IE39869B1 (en)
IL (1) IL45158A0 (en)
LU (1) LU70510A1 (en)
NL (1) NL7408705A (en)
NO (1) NO742351L (en)
RO (1) RO63539A (en)
SE (1) SE417316B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4082845A (en) 1977-04-25 1978-04-04 Merck & Co., Inc. 3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines
US4107309A (en) * 1977-05-23 1978-08-15 American Cyanamid Company Substituted imidazo[1,2-d]-as-triazines
US4091101A (en) * 1977-06-15 1978-05-23 Merck & Co., Inc. 6-(1-Piperazinyl)quinoxaline
EP0094498A3 (en) * 1982-05-06 1985-04-03 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
ES2042395B1 (en) * 1992-02-27 1994-06-16 Promotora Catalana De Inversio PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 2-CIANO-3-PIPERACINILQUINOXALINAS.
FR2731221B1 (en) * 1995-03-01 1997-05-30 Pf Medicament NOVEL DERIVATIVES OF ETHYL-1 DIHYDRO-1, 2 OXO-2 METHYLAMINO-3 QUINOXALINE, THEIR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
CA2308057A1 (en) * 1997-10-24 1999-05-06 Neurogen Corporation 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazines being dopamine d4 receptor subtype ligands
WO2000012500A2 (en) * 1998-09-02 2000-03-09 Neurogen Corporation 2-aryl-4-(1-[4-heteroaryl]piperazin-1-yl) methylimidazoles: dopamine d4 receptor subtype ligands
SE9901884D0 (en) * 1999-05-21 1999-05-21 Pharmacia & Upjohn Ab Novel compounds their use and preparation
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
EA005820B1 (en) * 1999-05-21 2005-06-30 Биовитрум Аб Agonists and antagonists of 5-ht2c receptors
JP4707261B2 (en) * 2001-05-15 2011-06-22 日本エンバイロケミカルズ株式会社 Quinoxaline compound and industrial bactericidal composition
CA2485537A1 (en) 2002-06-19 2003-12-31 Biovitrum Ab Novel compounds, their use and preparation
SE0202287D0 (en) * 2002-07-19 2002-07-19 Biovitrum Ab New compounds
WO2004009586A1 (en) 2002-07-19 2004-01-29 Biovitrum Ab Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders
JP4960085B2 (en) * 2003-03-19 2012-06-27 エクセリクシス， インク． TIE-2 modulator and usage
JP2007507514A (en) * 2003-09-30 2007-03-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Quinoxaline compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL260335A (en) * 1960-01-22
CH450434A (en) * 1961-12-14 1968-01-31 Ciba Geigy Process for the preparation of diazines
BE788451A (en) * 1971-09-08 1973-03-06 Bayer Ag NEW 2-AMINO-QUINOXALINES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS INSECTICIDES, ACARICIDES AND FUNGICIDES
GB1457400A (en) * 1972-11-20 1976-12-01 Pfizer Pharmaceutical compositions containing 2-substituted quinoxa lines

Also Published As

Publication number Publication date
SE7408486L (en) 1975-01-14
FR2236499B1 (en) 1977-04-15
RO63539A (en) 1978-07-15
GB1440722A (en) 1976-06-23
DK342674A (en) 1975-03-03
DE2433397A1 (en) 1975-02-06
NO742351L (en) 1975-02-10
BG21606A3 (en) 1976-07-20
JPS5037791A (en) 1975-04-08
AU7073174A (en) 1976-01-08
IE39869B1 (en) 1979-01-17
FI193974A (en) 1975-01-14
SE417316B (en) 1981-03-09
FR2236499A1 (en) 1975-02-07
NL7408705A (en) 1975-01-15
LU70510A1 (en) 1975-03-27
CH605919A5 (en) 1978-10-13
DD112127A5 (en) 1975-03-20
IE39869L (en) 1975-01-13
IL45158A0 (en) 1974-11-29

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