SE9901884D0 - Novel compounds their use and preparation - Google Patents

Novel compounds their use and preparation

Info

Publication number
SE9901884D0
SE9901884D0 SE9901884A SE9901884A SE9901884D0 SE 9901884 D0 SE9901884 D0 SE 9901884D0 SE 9901884 A SE9901884 A SE 9901884A SE 9901884 A SE9901884 A SE 9901884A SE 9901884 D0 SE9901884 D0 SE 9901884D0
Authority
SE
Sweden
Prior art keywords
ring
saturated
disorders
substituted
ring members
Prior art date
Application number
SE9901884A
Other languages
Swedish (sv)
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Priority to SE9901884A priority Critical patent/SE9901884D0/en
Publication of SE9901884D0 publication Critical patent/SE9901884D0/en
Priority to EA200101223A priority patent/EA005820B1/en
Priority to JP2001503842A priority patent/JP4831903B2/en
Priority to PCT/SE2000/001017 priority patent/WO2000076984A2/en
Priority to DE60024986T priority patent/DE60024986T2/en
Priority to CNB008102449A priority patent/CN1242995C/en
Priority to CA002374898A priority patent/CA2374898C/en
Priority to ES00931877T priority patent/ES2252004T3/en
Priority to KR1020017014888A priority patent/KR100722090B1/en
Priority to ARP000102461A priority patent/AR030022A1/en
Priority to BR0010783-2A priority patent/BR0010783A/en
Priority to NZ515786A priority patent/NZ515786A/en
Priority to AT00931877T priority patent/ATE313535T1/en
Priority to EP00931877A priority patent/EP1178973B1/en
Priority to MXPA01011905A priority patent/MXPA01011905A/en
Priority to MYPI20002186A priority patent/MY135666A/en
Priority to PE2000000479A priority patent/PE20010125A1/en
Priority to AU49690/00A priority patent/AU777276C/en
Priority to IL14658200A priority patent/IL146582A0/en
Priority to DK00931877T priority patent/DK1178973T3/en
Priority to US09/589,282 priority patent/US6465467B1/en
Priority to IL146582A priority patent/IL146582A/en
Priority to ZA200109571A priority patent/ZA200109571B/en
Priority to NO20015686A priority patent/NO322220B1/en
Priority to US10/269,670 priority patent/US7534794B2/en
Priority to HK03100371.6A priority patent/HK1048311B/en
Priority to US10/873,852 priority patent/US7071180B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

THE INVENTION RELATES TO COMPOUNDS OF THE GENERAL FORMULA(I) : WHEREIN AR IS OPTIONALLY SUBSTITUTED ARYL OR HETEROARYL ;A IS (I) -O-, -S-, -SO2-, -NH-, (II) A C1-4-ALKYL- OR C1-6-ACYL-SUBSTITUTED NITROGEN ATOM OR (III) A C1-8-ALKYLENE CHAIN OR A HETEROALKYLENE CHAIN HAVING 2 TO 8 CHAIN ATOMS, WHICH OPTIONALLY CONTAINS AT LEAST ONE UNSATURATION, AND WHICH MAY BE SUBSTITUTED AND/OR CONTAIN A BRIDGE TO FORM A SATURATED OR PARTIALLY OR FULLY UNSATURATED RING HAVING 3-8 RING MEMBERS ;B IS -C(R4)(R5)-, -OC(R4)(R5)-, -N(R6)C(R4)(R5)-, -N(R6)-, -O-, -S- OR -SO2- ;R IS OPTIONALLY SUBSTITUTED C3-8-CYCLOALKYL, ARYL OR HETEROARYL ;R1 IS (I) A SATURATED OR UNSATURATED AZACYCLIC OR AMINOAZACYCLIC RING, OR A SATURATED DIAZACYCLIC OR AMINODIAZACYCLIC RING, WHICH HAS 4 TO 7 RING MEMBERS, OR A SATURATED AMINOAZABICYCLIC, AZABICYCLIC OR DIAZABICYCLIC RING WHICH HAS 7 TO 10 RING MEMBERS, WHICH RINGS OPTINALLY ARE SUBSTITUTED IN ONE OR MORE POSITIONS, OR A GROUP -[C(R4)(R5)]xN(R2)(R3)] ; R2, R3, R4, R5, R6 AND x ARE AS DEFINED IN THE CLAIMS, AND N IS 0 OR 1 ;AND PHARMACEUTICALLY ACCEPTABLE SALTS, HYDRATES AND PRODRUG FORMS THEREOF. THE COMPOUNDS MAY BE PREPARED BY PER SE CONVENTIONAL METHODS AND CAN BE USED FOR TREATINGA HUMAN OR ANIMAL SUBJECT SUFFERING FROM A SEROTONIN-RELATED DISORDER, SUCH AS EATING DISORDERS, ESPECIALLY OBESITY, MEMORY DISORDERS, SCHIZOPHRENIA, MOOD DISORDERS, ANXIETY DISORDERS, PAIN, SEXUAL DYSFUNCTIONS, AND URINARY DISORDERS. THE INVENTION ALSO RELATES TO SUCH USE AS WELL AS TO PHARMACEUTICAL COMPOSITIONS COMPRISING A COMPOUND OF FORMULA (I).
SE9901884A 1999-05-21 1999-05-21 Novel compounds their use and preparation SE9901884D0 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
SE9901884A SE9901884D0 (en) 1999-05-21 1999-05-21 Novel compounds their use and preparation
DK00931877T DK1178973T3 (en) 1999-05-21 2000-05-19 Pyrazinyl-piperazine compounds, their use and preparation
AT00931877T ATE313535T1 (en) 1999-05-21 2000-05-19 PYRAZINYL-PIPERAZINE COMPOUNDS, THEIR APPLICATION AND PRODUCTION
MXPA01011905A MXPA01011905A (en) 1999-05-21 2000-05-19 Novel compounds, their use and preparation.
PCT/SE2000/001017 WO2000076984A2 (en) 1999-05-21 2000-05-19 Novel compounds, their use and preparation
DE60024986T DE60024986T2 (en) 1999-05-21 2000-05-19 PYRAZINYL-PIPERAZINE COMPOUNDS, THEIR USE AND MANUFACTURE
CNB008102449A CN1242995C (en) 1999-05-21 2000-05-19 Novel compounds, their use and preparation
CA002374898A CA2374898C (en) 1999-05-21 2000-05-19 Pyrazinyl-piperazine compounds, their use and preparation
ES00931877T ES2252004T3 (en) 1999-05-21 2000-05-19 NEW COMPOUNDS, ITS USE AND PREPARATION.
KR1020017014888A KR100722090B1 (en) 1999-05-21 2000-05-19 Novel compounds, their use and preparation
ARP000102461A AR030022A1 (en) 1999-05-21 2000-05-19 NEW COMPOUNDS, PHARMACEUTICAL COMPOSITIONS OF THE SAME, TREATMENT METHOD, USE AND PREPARATION OF THEM
BR0010783-2A BR0010783A (en) 1999-05-21 2000-05-19 New compounds, their use and preparation
NZ515786A NZ515786A (en) 1999-05-21 2000-05-19 Aryl compounds, their preparation and use in the preparation of medicaments for the treatment of serotonin-related disorders
EA200101223A EA005820B1 (en) 1999-05-21 2000-05-19 Agonists and antagonists of 5-ht2c receptors
EP00931877A EP1178973B1 (en) 1999-05-21 2000-05-19 Pyrazinyl-piperazine- compounds, their use and preparation
JP2001503842A JP4831903B2 (en) 1999-05-21 2000-05-19 Novel compounds, their use and production
MYPI20002186A MY135666A (en) 1999-05-21 2000-05-19 Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
PE2000000479A PE20010125A1 (en) 1999-05-21 2000-05-19 PIPERAZINYL-PIRAZINE DERIVATIVE COMPOUNDS THAT BIND TO THE 5-HT 2C RECEPTOR
AU49690/00A AU777276C (en) 1999-05-21 2000-05-19 Novel compounds, their use and preparation
IL14658200A IL146582A0 (en) 1999-05-21 2000-05-19 Novel compounds, their use and preparation
US09/589,282 US6465467B1 (en) 1999-05-21 2000-06-08 Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
IL146582A IL146582A (en) 1999-05-21 2001-11-19 Compound for treating a serotonin-related disease, particularly 5-ht2 receptor-related
ZA200109571A ZA200109571B (en) 1999-05-21 2001-11-20 Novel compounds, their use and preparation.
NO20015686A NO322220B1 (en) 1999-05-21 2001-11-21 New compounds, their use and manufacture
US10/269,670 US7534794B2 (en) 1999-05-21 2002-10-11 Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
HK03100371.6A HK1048311B (en) 1999-05-21 2003-01-15 Compounds, their use and preparation
US10/873,852 US7071180B2 (en) 1999-05-21 2004-06-22 Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9901884A SE9901884D0 (en) 1999-05-21 1999-05-21 Novel compounds their use and preparation

Publications (1)

Publication Number Publication Date
SE9901884D0 true SE9901884D0 (en) 1999-05-21

Family

ID=20415714

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9901884A SE9901884D0 (en) 1999-05-21 1999-05-21 Novel compounds their use and preparation

Country Status (6)

Country Link
JP (1) JP4831903B2 (en)
AR (1) AR030022A1 (en)
MY (1) MY135666A (en)
PE (1) PE20010125A1 (en)
SE (1) SE9901884D0 (en)
ZA (1) ZA200109571B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1608373A4 (en) * 2003-03-19 2010-09-29 Exelixis Inc Tie-2 modulators and methods of use
CL2004000826A1 (en) * 2003-04-25 2005-03-04 Pfizer USE OF AN AGONIST FOR THE 5-HT2C RECEPTOR TO PREPARE A USEFUL MEDICINAL PRODUCT IN THE TREATMENT OF URINARY INCONTINENCE CAUSED BY STRESS, WITH THE CONDITION THAT THE AGONIST IS NOT 1- [6-CHLORINE-5- (TRIFLUOROMETIL) -2- PIRIDINIL] PIPERAZINA (ORG-129
EP2418191A1 (en) 2005-02-28 2012-02-15 Meiji Co., Ltd. Long-chain trimethoxyphenylalkanol derivatives, and pharmaceuticals comprising the same
BRPI0615248A2 (en) * 2005-08-26 2009-07-14 Shionogi & Co derivative having ppar agonist activity
JP6635999B2 (en) * 2017-10-13 2020-01-29 株式会社ダイセル Method for producing potassium salt, and potassium salt

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI193974A (en) * 1973-07-13 1975-01-14 Merck & Co Inc
GB9420999D0 (en) * 1994-10-18 1994-12-07 Smithkline Beecham Plc Novel compounds

Also Published As

Publication number Publication date
ZA200109571B (en) 2002-11-20
JP2003502317A (en) 2003-01-21
AR030022A1 (en) 2003-08-13
MY135666A (en) 2008-06-30
PE20010125A1 (en) 2001-02-06
JP4831903B2 (en) 2011-12-07

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