ES2042395B1 - PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 2-CIANO-3-PIPERACINILQUINOXALINAS. - Google Patents

PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 2-CIANO-3-PIPERACINILQUINOXALINAS.

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Publication number
ES2042395B1
ES2042395B1 ES9200430A ES9200430A ES2042395B1 ES 2042395 B1 ES2042395 B1 ES 2042395B1 ES 9200430 A ES9200430 A ES 9200430A ES 9200430 A ES9200430 A ES 9200430A ES 2042395 B1 ES2042395 B1 ES 2042395B1
Authority
ES
Spain
Prior art keywords
formula
derivatives
piperacinilquinoxalinas
ciano
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9200430A
Other languages
Spanish (es)
Other versions
ES2042395A1 (en
Inventor
Ges Jose Maria Caldero
Vega Antonio Monge
Rio Zambrana Joaquin Del
Cubillo Juan Antonio Palop
Aldaz Berta Lasheras
Castillo Nieto Juan Carlos Del
Acin Juan Roca
Rovira Anna Bosch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PROMOTORA CATALANA DE INVERSIO
Original Assignee
PROMOTORA CATALANA DE INVERSIO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PROMOTORA CATALANA DE INVERSIO filed Critical PROMOTORA CATALANA DE INVERSIO
Priority to ES9200430A priority Critical patent/ES2042395B1/en
Publication of ES2042395A1 publication Critical patent/ES2042395A1/en
Application granted granted Critical
Publication of ES2042395B1 publication Critical patent/ES2042395B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 2-CIANO-3-PIPERACINILQUINOXALINAS DE FORMULA I Y SUS SALES, SOLVATOS Y DERIVADOS PROTEGIDOS FARMACEUTICAMENTE ACEPTABLES, BASADO EN LA SUSTITUCION DE UN GRUPO HALOGENO EN LA POSICION 3 DE UNA 2-CIANO-3-HALOQUINOXALINA DE FORMULA IV FORMULA (DONDE X = HALOGENO), POR UNA PIPERACINA SUSTITUIDA DE FORMULA V. FORMULA ESTOS PRODUCTOS SON ANTAGONISTAS SELECTIVOS DE LOS RECEPTORES 5HTSI3 SC Y SON UTILES, POR EJEMPLO, EN EL TRATAMIENTO DE NAUSEAS Y VOMITOS, TRANSTORNOS DE VACIADO GASTRICO, CUADROS DE ANSIEDAD Y REACCIONES PSICOTICAS.PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 2-CIANO-3-PIPERACINILQUINOXALINAS OF FORMULA I AND ITS SALTS, SOLVATES AND PHARMACEUTICALLY ACCEPTABLE PROTECTED DERIVATIVES, BASED ON THE SUBSTITUTION OF A HALOGEN GROUP 3-2-AXA IV FORMULA (WHERE X = HALOGEN), BY A PIPERACINE SUBSTITUTED FORMULA V. FORMULA THESE PRODUCTS ARE SELECTIVE ANTAGONISTS OF THE 5HTSI3 SC RECEPTORS AND ARE USEFUL, FOR EXAMPLE, IN THE TREATMENT OF NAUSEAS AND VOMITES, TRANSTAN ANXIETY AND PSYCHOTIC REACTIONS.

ES9200430A 1992-02-27 1992-02-27 PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 2-CIANO-3-PIPERACINILQUINOXALINAS. Expired - Fee Related ES2042395B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9200430A ES2042395B1 (en) 1992-02-27 1992-02-27 PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 2-CIANO-3-PIPERACINILQUINOXALINAS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9200430A ES2042395B1 (en) 1992-02-27 1992-02-27 PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 2-CIANO-3-PIPERACINILQUINOXALINAS.

Publications (2)

Publication Number Publication Date
ES2042395A1 ES2042395A1 (en) 1993-12-01
ES2042395B1 true ES2042395B1 (en) 1994-06-16

Family

ID=8276207

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9200430A Expired - Fee Related ES2042395B1 (en) 1992-02-27 1992-02-27 PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 2-CIANO-3-PIPERACINILQUINOXALINAS.

Country Status (1)

Country Link
ES (1) ES2042395B1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002212888A1 (en) * 2000-11-01 2002-05-15 Respiratorius Ab Composition comprising: serotonin receptor antagonists (5ht-2, 5ht-3) and agonist (5ht-4)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI193974A (en) * 1973-07-13 1975-01-14 Merck & Co Inc

Also Published As

Publication number Publication date
ES2042395A1 (en) 1993-12-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201