ES2042395A1 - Cyano piperazinyl quinoxaline deriv. prepn. - Google Patents

Cyano piperazinyl quinoxaline deriv. prepn.

Info

Publication number
ES2042395A1
ES2042395A1 ES929200430A ES9200430A ES2042395A1 ES 2042395 A1 ES2042395 A1 ES 2042395A1 ES 929200430 A ES929200430 A ES 929200430A ES 9200430 A ES9200430 A ES 9200430A ES 2042395 A1 ES2042395 A1 ES 2042395A1
Authority
ES
Spain
Prior art keywords
cyano
piperazinyl
prepn
deriv
quinoxaline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES929200430A
Other languages
Spanish (es)
Other versions
ES2042395B1 (en
Inventor
Ges Jose Maria Caldero
Vega Antonio Monge
Rio Zambrana Joaquin Del
Cubillo Juan Antonio Palop
Aldaz Berta Lasheras
Castillo Nieto Juan Carlos Del
Acin Juan Roca
Rovira Anna Bosch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PROMOTORA CATALANA DE INVERSIO
Original Assignee
PROMOTORA CATALANA DE INVERSIO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PROMOTORA CATALANA DE INVERSIO filed Critical PROMOTORA CATALANA DE INVERSIO
Priority to ES9200430A priority Critical patent/ES2042395B1/en
Publication of ES2042395A1 publication Critical patent/ES2042395A1/en
Application granted granted Critical
Publication of ES2042395B1 publication Critical patent/ES2042395B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

2-Cyano 3-piperazinyl qunoxalines of formula (I), which are selective antagonists of 5HT3 receptors and useful for treatment of nausea, vomiting, gastric complaints, anxiety states and pyschotic reactions, are made by replacing halogen in 2-cyano 3-halo quinoxalines with a substituted piperazinyl gp.
ES9200430A 1992-02-27 1992-02-27 PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 2-CIANO-3-PIPERACINILQUINOXALINAS. Expired - Fee Related ES2042395B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9200430A ES2042395B1 (en) 1992-02-27 1992-02-27 PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 2-CIANO-3-PIPERACINILQUINOXALINAS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9200430A ES2042395B1 (en) 1992-02-27 1992-02-27 PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 2-CIANO-3-PIPERACINILQUINOXALINAS.

Publications (2)

Publication Number Publication Date
ES2042395A1 true ES2042395A1 (en) 1993-12-01
ES2042395B1 ES2042395B1 (en) 1994-06-16

Family

ID=8276207

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9200430A Expired - Fee Related ES2042395B1 (en) 1992-02-27 1992-02-27 PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 2-CIANO-3-PIPERACINILQUINOXALINAS.

Country Status (1)

Country Link
ES (1) ES2042395B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036113A1 (en) * 2000-11-01 2002-05-10 Respiratorius Ab Composition comprising: serotonin receptor antagonists (5ht-2, 5ht-3) and agonist (5ht-4)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2236499A1 (en) * 1973-07-13 1975-02-07 Merck & Co Inc

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2236499A1 (en) * 1973-07-13 1975-02-07 Merck & Co Inc

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICINAL CHEMISTRY, Vol. 24, 1981, p. 93-101, LUMMA et al., "Piperazinylquinoxalines with Central Serotoninmimetic Activity". *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036113A1 (en) * 2000-11-01 2002-05-10 Respiratorius Ab Composition comprising: serotonin receptor antagonists (5ht-2, 5ht-3) and agonist (5ht-4)

Also Published As

Publication number Publication date
ES2042395B1 (en) 1994-06-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201