ES427536A1 - Procedure for the production of piperidine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the production of derivatives of piperidine, of formula I **(See formula)** wherein R1 is phenethyl, phenethyl monosubstituted in the phenyl ring by fluorine, chlorine, bromine, lower alkyl or lower alkoxy, butyrophenone or butyrophenone monosubstituted in the phenyl ring by fluorine, chlorine, bromine, lower alkyl or lower alkoxy, R2 is a group OR5, where R5 is lower alkyl, lower alkenyl, phenyl or phenyl monosubstituted by fluorine, chlorine, bromine, lower alkyl or lower alkoxy, or a group **(See formula)** wherein each of R6 and R7, independently, is hydrogen, lower alkyl or cycloalkyl alkyl, cycloalkyl, phenyl, phenyl monosubstituted by fluorine, chlorine, bromine, lower alkyl or lower alkoxy, phenylalkyl or phenylalkyl monosubstituted in the phenyl ring by fluorine, chlorine, bromine, lower alkyl or lower alkoxy, or where R6 and R7 together with the nitrogen atom to which they are attached form a saturated 5- to 6-membered ring heterocycle, which may optionally contain oxygen, sulfur as the second heteroatom or nitrogen substituted by lower alkyl, R3 is lower alkyl, cycloalkylalkyl, cycloalkyl, phenyl or phenyl monosubstituted by fluorine, chlorine, bromine, lower alkyl or lower alkoxy, and R4 is hydrogen or lower alkyl, or R3 and R4 together with the atom of carbon to which they are attached form a cycloalkyl ring of 4 to 6 carbon atoms, characterized in that: a compound of formula II is reacted, **(See formula)** wherein R2, RI3 and R4 have the meanings indicated above, with a compound of formula III **(See formula)** where R1 has the meaning indicated above, and X is the acidic radical of a reactive ester, preferably in an inert organic solvent, preferably at a temperature between 20º and 100ºC. (Machine-translation by Google Translate, not legally binding)